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PCSK9 inibitors are the best option for reducing lipids. Highly effective and pretty much side effect free. It has not been my experience that they cause hyperglycemia and a I'm not aware of any evidence that they do. Since PCSK9 inhibitors were developed to mimic a genetic mutation that...

You probably know all this, but here's my speculation as to what's happening. From Bhasin, the incidence of side effects from supraphysiologic doses of testosterone is higher in older men, than in young men. Older men are as responsive as young men to the anabolic effects of graded doses of...

To be expected. SHBG is partially regulated by insulin levels. Low average insulin, high SHBG. High average insulin, low SHBG. There's still a lot of genetic variation of SHBG between individuals and other things can affect levels, but go from high to low insulin and most will see a sizable...

I've spent some time now reading some of the L. Cole papers. To summarize he has identified HCG molecules that that are present in HCG producing tumors and are also present in urine derived HCG pharmaceuticals. He has identified plausible mechanisms by which these HCG molecules promote cancer...

My understanding is that all compounded HCG in the US is uHCG. EmpowerPharmacy

Starting a new thread for better visibility. From Madman's post Illicit use of hCG in dietary programs and to promote anabolism: The above statements are very concerning for anyone using HCG. The quote if from a medical text written by Laurence Cole and Stephen Butler. Laurence Cole is...

"It is inferred that these urinary-derived hCG preparations are highly carcinogenic" This is a very strongly worded conclusion, that is pretty concerning. The referenced research papers are dealing with HCG secreting tumors which is a different problem than using exogenous HCG. However the...

Drugbank typoed the terminal half life values. Should be days not hours. From the source paper: The pharmacokinetics of nandrolone in serum and urine were investigated in healthy young men after a single im injection of 50 mg (n = 20), 100 mg (n = 17), or 150 mg (n = 17) nandrolone...

What's your preferred approach for micro-dosing? Inject at multiple locations around the injury at the same time or inject at the injury multiple times a day?

I just reviewed my log of historical hematocrit results and for me there is no associated pattern of increased hematocrit during the time frames that I've used NAC. For me hematocrit is correlated with testosterone status.

Given the seriousness of COVID, taking action to improve immune system function is likely to be important. Anecdotally, I've noticed that TRT has reduced my incidence of seasonal respiratory illness (1 cold in 2 years, rather than several every year). I'd be interested in hearing from Nelson...

Looking back over my historical labs my SHBG doubled to 38 when on a keto diet. Given that there are multiple factors that affect SHBG, it's not suprising that insulin doesn't have an affect for some people.

I haven't seen this mentioned previously. This suggests that those who are struggling with low SHBG should test for hyperinsulineamia. The relationship between serum levels of insulin and sex hormone-binding globulin in men: the effect of weight loss. As SHBG is not known to alter the...

I don't have any experience with cycles, but this applies for TRT restarts as well as cycles. It is important to remember that relatively small amounts of circulating exogenous testosterone will suppress pituitary production of LH. If stopping testosterone, one would want to continue with HCG...

The only study I know of is this one: The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men Older men had higher body fat levels and also higher estradiol conversion.

You need a full thyroid panel. Your TSH is abnormal if confirmed in a repeat test. Thyroid should be addressed before pursuing TRT. Are you overweight? If so, loosing weight will drop the estradiol. Doing a sleep study is the right answer for someone with your hematocrit. You can have...

Probably not what you were looking for but this is the closest thing out there. Valisure is a pharmacy that actually tests every batch of medication they sell for purity and strength. Not licensed in all states, doesn't take insurance, and only for a limited number of medications. Home -...

Here's the study I was referring to: Quantitative Analysis of NAD Synthesis-Breakdown Fluxes Summary The redox cofactor nicotinamide adenine dinucleotide (NAD) plays a central role in metabolism and is a substrate for signaling enzymes including poly-ADP-ribose-polymerases (PARPs) and...

There was a recent tracer study that showed that all of the uptake of NR/NMN is in the liver. None of it makes it to other tissues. So most like not going to be much benefit from this supplement.

Just read the full study text. Unfortunately it is difficult to draw any conclusions due to the study design. It wasn't conducted as a cross-over trial. There is a huge amount of variability in individual response to aerobic exercise. Some people are non-responders and others are...

Old study that looked at exogenous estrogen (among other things) in men targeted at reducing mortality due to cardiac events: The Coronary Drug Project: findings leading to discontinuation of the 2.5-mg/day estrogen group. The purpose of the Coronary Drug Project, a national collaborative...

I was thinking of adding glutes and dropping quads from injection site rotation. Currently rotate between quads, deltoids, and VG, shallow IM. I'm finding that I tend to get injection site soreness for a few days when injecting in the quads. Anyone self inject in the glutes? If so do, how do...

Nelson, Have you considered adding Labcorp test 070001? Might be a cheaper option for those who just want to know total testosterone levels and may be above the 1500 limit. Also I would say it's not just for body builders. Sometimes you make a dose change on TRT and end up higher than...

It will vary by individual. The only way to know what your fiance's response will be to try it and get bloodwork. For reference, here's my response to different HCG doses (no exogenous testosterone). All doses taken every 3 days, bloodwork 24 hours post injection, Estradiol tested with LCMS...

Nelson, Any chance these tests could made available via Discounted Labs?

Did the date for this event change? First post says 2/26, eventbrite shows 2/22. Which one is correct?

HCG derived from purified urine has the potential to contain infectious agents from the urine donors. I've found the following papers that address these risks. Overall it seems that the risk of viral or prion infection from urinary HCG is low, but not zero. Expert Workshop on CJD Risk and...

Great video. Very informative. Did you get any info. on the thought process for the high dose HCG being used in some of the Baylor clinic protocols? 3000IU QOD is a pretty high dose compared to what most state they are prescribed.

Enlis offers an Enlis personal service for a fee where you send them you raw DNA data and they send you back a file that can be loaded into their software to explore. I haven't used Prometheus, so I can't compare to it. The Enlis software allows you to look at any SNP in the data and to load...

There are certainly accuracy issues with these tests, but that doesn't mean that they are not useful. Since I can't post links, here's the text of one company's analysis: "Identifying hundreds of inaccurate SNPs with high-impact in 23andMe raw data" While developing and testing our Enlis...

I'm a current patient of Dr. Lipshultz at Baylor. Is he leaving Baylor? or is the new clinic going to be in addition to seeing patients at Baylor? My experience with wait times has ranged from 30 sec to 2 hours at his Baylor clinic. Just something you should plan for. He's been a great...