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You can also look at percentages, why not spend the extra dollar or two, for the Methyl versions of B vitamins. You have a 50/50 chance you have an issue. Unless you are Italian, then (it might be Sicilians) you have a 65% chance of the 607 defect(this is the one that has a high incidence of...

For those who don't know about MTHFR genetic defects, by coincidence, got this in an email today: Methylenetetrahydrofolate Reductase (MTHFR) is an important enzyme in the methylation cycle, which limits how quickly and efficiently methylation can happen in the body. Methylation is a critical...

Have you tested your (sensitive) CRP (C Reactive Protein) a marker for inflammation? My insurance policy covered my MTHFR testing, (although I do have an immune disease, maybe that warranted the test) I have one side of the A1298C, my wife the C677T defect, unfortunately, my son was tested and...

My wife and I each have one MTHFR defect. I was required for more than a decade to take Folic Acid(3mg/QD) because I was on Methotrexate (stopped a year ago), since that version might not be absorbed, I switched to MethylFolate, and Methyl B12.

I take both products, and an anti immune drug Embrel. My son see's a top functional MD in NYC (he has connections in the sports world, and got a Dr Oz MD as his PCP) he has Hashimotos , and takes LDN for that, he does not take any thyroid drugs however, it is just his labs are fairly high. I...

These are sad results, especially for a group of younger males. "Mean T levels at 8am were 423ng/dl for the normal group and 228ng/dl for the low group (p¼0.008). Researchers are not helping develop a healthier male population when they consider this "normal". "Men were categorized as having...

Thanks for the posts, both Nelson and Vince. Vince, I wondered if dose timing had helped anyone,(thnaks for your thoughts) I didn't think it could, but wondered if anyone had luck. I have several medical issues that explain my low SHBG, but there is so little info on how we should be treated.

The question is, does low SHBG effect this ratio, and of course, the important issue: libido? My E2 (at last labs) was 24, trough was 538 and peak was 838, so, my ratio (for total, not free) would be above 20. But, does the "optimal" E2 level of (aprox) 25 actually apply to guys with SHBG below...

Nelson, for us low SHBG guys, Free T is basically all that matters as far as Test labs, if this is the case, does free E2 also only matter, and not total E2? I just tested a Trough & Peak for my scrotal cream to measure T and DHT. Next planed labs is free E2, I have never used any AI, but maybe...

I am reviewing as many of the older posts on Free E2, for those of us with low SHBG, (my highest is around 15 for past few years). From your comment on 12 hours, have you adjusted your dosing time? Do you always inject in the early AM? So the higher E2 doesn't kick in until you are in bed?

"The normal range of testosterone is reported as 350- 1200ng/dl. Studies in the 1940's showed the average testosterone level to be at 700 ng/dl, 300 ng/dl higher than for men today. In the past, a drop in testosterone levels to 250 ng/dl was rarely reported before men were 80 years of age. Yet...

I passed on any tests other than TT, FT and DHT, I wanted to see the effect of TCyp injection and scrotal cream application. My E2 is usually in the optimal area, 20-25 most tests, but, I wonder if I really need much E2 for a better Libido, considering my history of low SHBG. As to the effect of...

I have very low SHBG, in the past few years, between 10- 16. More than likely related to an auto immune disease, or the drugs used to control my RA. I take 20 mg of T cyp 3 x week, so that is about 8.5 mg daily. This trough is a little lower than what I usually test at, over the past few years...

I was buying it from a larger city compounding pharmacy for about $115, and that would last almost 6 months. I discovered I was overpaying, so, spoke with a local, small town, pharmacy, I now pay about $50, for same dosage, and again I only need 2 - 3 tubes a year.

Assume, I should post my recent labs here, I use both T cyp injection and daily scrotal T cream. I have been taking 20 mg of T cyp, M,W,F, and daily I use a single click of a 200 mg T cream, the amount is aprox 3/4" x 1/4". It is the same every dose. So I was due for labs, and decided to do a...

It depends where you live in the USA, but grass fed beef is available in many grocery stores lately. Myself, I buy grass fed (or pastured) beef or pork direct from the farm. The only issue is, my wife has cut back on pork after I brought her to see new baby pigs, she knows what they look like. I...

I had quite a bit of experience with conventional MS drugs, according to Drugs.com, a patient forum, it turns out that those using LDN for MS self reported the highest effect levels at 72% (higher than copaxone ,etc) Even better, those with MS self report feeling the effects within (as quickly...

I also have been taking LDN for greater than a decade. I use either a new (unopened) 500ml bottle of water (or Zero filtered water and place it in a canning jar). I add one (1) 50 mg tab of Naltrexone, and gently stir it. (dissolves quickly)That creates a 10ml = 1 mg dosage. I take 4mg QHS...

My last labs looked overall pretty good, except CKD, Creatinine has been 1.30- 1.34 over the past few years. My nephrologist is not concerned because the labs have been steady for some time. Assume the kidney issues are RA related. Last Labs: TT 846 Ft 18.9 SHBG 15.6 E2...

I have appropriate LH and FSH levels, and have almost from the beginning of starting TRT. I use Embrel (which is an immune suppressant) (I was able to wean off methotrexate almost a year ago, A chemo drug) and I take 4.5mg every bedtime of LDN, in my case, it is not reversing the "immune...

I didn't look at shipping costs, but at less than $2.50 a tab, it is worth a short term experiment to see if it helps. I would assume a 6 month trial is about the minimum. The starting dosage is usually 1.5ml at bedtime. The easiest way to "make" it is to take one 50mg tab, dropped into a 500ml...

Finding an MD who actually knows what LDN is the biggest issue. If you live in a state where they have Naturopaths that could speed up the process. Myself, I have a functional PCP and my Rheumatologist is also a functional MD, so, she encouraged me to continue taking LDN (which is an immune...

A topic that concerns me the most, even above T levels, is inflammation.. I have RA, and use both LDN and a (RA stronger) strain of *** with less THC as a tincture at bedtime. Having had CRP levels in the 80's, I understand why testing helps monitor inflammation. For the past few years, still on...

Thanks, you wrote all the info I have forgotten, its been years since I read about, and treated my leaky gut. I started out with Paleo, then Gluten Free, then reintroduced grains and legumes, but, I followed the suggestions in Weston A Price's cook book on how to reduce the Lectins in those foods.

Having an auto immune disease, and hypothyroidism, I was concerned about Lectins. When I prepare either beans or oatmeal, I soak them for 24 hours in filtered /well water, and add about a table spoon of buckwheat. Sara Pope from Weston A. Price Foundation and also she is the The healthy home...

It appears from your weight loss you are well disciplined and can follow through on a diet plan and exercise. There are many options for you. For many, I think finding (gym) friends to go with you creates more fun and accountability. I go 3x week (I am retired) with 2 other fellas that are both...

I was diagnosed with RA (Rheumatoid Arthritis) almost 15 years ago, I didn't think much about sex or T levels at the time. (related to pain) Once my RA got under control, I started doing a fair amount of research about the disease and alternatives to standard meds. I read that 65% of men with RA...

I do not take any pain meds myself, ever, NSAIDs would just lead to other issues, so I stay away. You are correct on the usage of standard dosing of Naltrexone at 50mg as an anti opioid drug, not withdrawal. LDN helps with increasing Dopamine receptors, not increasing Dopamine itself, hence the...

I have RA another (more common) autoimmune disease, so I know the stats for my group, 65% of men with RA have low T. The reason I am writing is to mention LDN for you, (low dose Naltrexone) it is an immune booster or modulator (at the low doses). There are a fair amount of sites related to its...

I have used several drugs for my RA that are not commonly used. One is LDN and the other, which may help you, is marijuana. I did have a medical marijuana card, but my state now allows recreational purchases, so I don't need the card any longer. I use a strain that is more of the *** than THC, I...

I don't think that the shift work is the sole reason for the way you feel, BUT, it appears that is the biggest issue at this time. Night shift screws up your adrenal gland and the whole Circadian rhythm. Is another shift a possibility? Or cutting back hours?I worked myself as a night shift...