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IMO, the back-filling would be subject to new patient who is deficient (back-filling helps speed recovery), or, for longer term TRT subject who might be slowly deficient. Pregnenolone is not a reliable marker. Progesterone is slightly more $$. 170H-Progesterone sits atop the Cortisol cascade...

So, the StAR expression is stimulated by LH (hCG mimics), which starts the p450scc enzyme to produce Pregnenolone from cholesterol. Then Pregnenolone converts to Progesterone (3B-HSD via StAR) or to 17OH-Pregnenolone (17,20 lyase via StAR). These two can convert to 17OH-Progesterone (by same...

Really good post, Nelson! Thank you.

All four naturally occur in the body, but will not necessarily convert if there is a minimum present. Adding them could be of benefit. I'm familiar with L-Carnitine and NAC, don't know about the other two. "Each carnitine analog has its own unique chemical structure. Your body will therefore...

I use Beverly International proteins, vit/min pak, and aminos. They market this product for those over 35: http://beverlyinternational.com/products/Quadracarn.html It has 4 analogs: l-carnitine, n-acetyl-l-carnitine, propionyl-l-carnitine and l-carnitine l-tartrate Would this still be a good...

Had my consult today: 80 mg T 2x/week (ex. T & Fr) 500 IU hCG 2x/week (ex. M & Th) 25 mg DHEA 2x/day Blood re-test at 8 weeks.

I guess SBHG and FSH were never part of the panel - OK. Maybe not worth the cost. With TT, FT, and E2 so low, it' obvious what the plan is. SBHG is probably low as well. The starting point is probably not all that significant in the overall picture, and reducing the upfront cost is always...

Thanks for your replies, That was the sleep Dr., not my PCP. He should know better, though. I went there thinking bad REM sleep would cause Low T (now I know it is the reverse). I don't have much hope with the Endo. I don't know if I'll keep the appointment or not. Yeah, it doesn't matter at...

55 years old, lift 4x week (45-60 min), eat fairly clean, no other health concerns, no OTC meds or meds of any kind. 6'4", 235 lbs. Never used steroids. Supplement with protein, multi vit/min, creatine, beta-alanine, and aminos. I've been feeling like somebody dropped the boat anchor (just...