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  1. Dr. John Crisler

    Quest Diagnostics Ultrasensitive Estradiol Code

    The aforementioned thread by Nelson is a great post, emphasizing you MUST run the more sensitive estradiol assay. The standard assay is not valid for adult males, and usually over-estimates the true E concentration. This may lead to inappropriate use of an aromatase inhibitor, to the detriment...
  2. Dr. John Crisler

    Quest Diagnostics Ultrasensitive Estradiol Code

    The code, and range, provided in this thread: Suggested Lab Tests and Questions Before and After Initiation of Testosterone Replacement ...needs an edit. The proper code is 30289, and range is "<29" (I am unable to reply to that thread directly)
  3. Dr. John Crisler

    Estradiol (standard vs. sensitive)

    I see numbers...but not a word about how you FEEL...
  4. Dr. John Crisler

    Estradiol (standard vs. sensitive)

    Right, Nelson, and compounded (pun intended) by the fact they treat to numbers, not actual symptoms. IF there are no elevated symptoms, I do not add an AI.
  5. Dr. John Crisler

    Estradiol (standard vs. sensitive)

    That's pretty common, as the Standard assay greatly overestimates the actual concentration of E2.
  6. Dr. John Crisler

    Gynecomastia: Clinical evaluation and management

    Without further evaluation--including labs--it's not possible to say. But nipples which are increasing in size is indeed a sign of gynocomastia. Since we talked about it, I hope the estrogen test is appropriate for an adult male; that is to say an enhanced laboratory methodology. IF the...
  7. Dr. John Crisler

    Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck

    Have they been shown to be so in adult males? Or is he extrapolating? All these years, hundreds of patients, and not a single event while on Arimidex.
  8. Dr. John Crisler

    Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck

    Have they been shown to be so in adult males? Or is he extrapolating? All these years, hundreds of patients, and not a single event while on Arimidex.
  9. Dr. John Crisler

    Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck

    How much faith do we have in the 1-2% incidence claim? IF there is going to be an issue, he says it will show up in the first 3 months. This sure does warrant an additional two questions on Medical History (personal and Family Medical History).
  10. Dr. John Crisler

    Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck

    How much faith do we have in the 1-2% incidence claim? IF there is going to be an issue, he says it will show up in the first 3 months. This sure does warrant an additional two questions on Medical History (personal and Family Medical History).
  11. Dr. John Crisler

    Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck

    "1-2% of men taking T will develop blood clots related to underlying inherited clotting abnormalities or to acquired thrombophilia (the antiphospholipid antibody syndrome)." I have not seen a single case of this in a dozen years of prescribing TRT, including use of anastrazole, on a daily...
  12. Dr. John Crisler

    Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck

    "1-2% of men taking T will develop blood clots related to underlying inherited clotting abnormalities or to acquired thrombophilia (the antiphospholipid antibody syndrome)." I have not seen a single case of this in a dozen years of prescribing TRT, including use of anastrazole, on a daily...
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