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have you tried Magnesium? 800mg per day, in divided doses, has lowered the blood pressure for many. It's also a great supplement for those who are on TRT.

Thank you! This is the first I've seen this study. I've never been able to figure out why it is Endocrinology is the only field of medicine where the half life of the medication is completely ignored. It's also the only area of medicine where "normal range" has nothing to do with health, or...

Transdermals are preferable--for the individuals who absorb well, and lifestyle allow--because they most closely mimic the natural rhythms of the body. They are the most physiologic TRT modality available.

I love it. Wouldn't go back to IM. ...so agree many hundreds of my patients.

The most usual cause of low(er) SHBG is inflammation. This has been shown as the actual cause with Type II Diabetes. An anti-inflammatory diet is first. Then fish oil, curcurmin, mixed Vit E's etc should help.

It's important to know dosing of medications used in Interventional Endocrinology go far beyond a consideration of the half-life of the drug. First, basically, what hormones really do is transmit information around the body. To the cells, where they may interact from the outside of the cell...

Like a cork bobbing on top of the water, I just play SHBG where it settles in my patients. Having said that, the most common cause of SHBG that is low(er) I have found is INFLAMMATION. This has actually been found to be the cause of low(er) SHBG in DMII patients--not the actual elevated...

Hi guys! I'll be checking in to see if I can help out a bit. I'd like to add that I have been sending my patients to www.DiscountedLabs.com when they either have to pay out-of-pocket, or if their medical insurance coverage is not very good, saving them a lot of money. Used them hundreds of...

What he said.

Excellent question. IGF-1 increases cancer risk IF IGFBP-3 levels are not sufficient. Usually, when GH increases IGF-1, the liver also elevates IGFBP-3 to match. If not, there is a problem. Bodybuilders taking straight IGF-1 is absolutely insane. There is no matching IGFBP-3 increase in that...

I would offer an edit to Jerry's otherwise excellent article. IGFBP-3, which is both primary carrier of IGF-1, and an important part of the p53 apoptosis (cancer cell seek-and-destroy) mechanism, does not "render IGF-1 harmless." Rather, it is a true carrier protein, and so extends the life of...

StAR is why I always want my TRT patients on HCG, which is a mimic of LH. This is all part of "Backfilling the Pathways". Helping with Testicular Atrophy is icing.

It was actually considered a major heart attack. I had a complete right side blockage, thanks to a lone anomalous plaque rupture. Had the total situation been any different (i.e. when the ambulance arrived at my home, I was lying on the front steps, and the Cath Lab was already prepped and ready...

I'll share with you that I am currently injecting about 6mg per day. I feel GREAT.

It's as if the Powers-That-Be in LA are bound determined to keep them in the last millenium. Louisiana fought, tooth and nail, to prevent Osteopathic physicians from being licensed there. They clearly do not have the best interests of the People in mind. It's embarrassing, really, as their...

Here here!

Excellent point. Some men are what we call Hypermetabolizers, and some are Hyperexcreters (into the urine). But we handle this by using various strategies in the TRT regimen, such as shorter dosing intervals, and using shots instead of gels (although--as always--everyone is different). The...

I've only seen E2 that high in alcoholics, due to shunting from Androstenedione. Don't want to set you off, though! LOL

Please note the bolded. Yup--estrogen issues. LOL Seriously, it amazes me when people--especially my colleagues--claim estrogen should not be manipulated. I've literally seen thousands of men have their negative estrogen symptoms dry up with Anastrazole.

The multitude and magnitude of the various negative influences which downgrade endogenous testosterone production may never be known. From the lectures I have attended by Dr. Reiter, re-establishing circadian rythm--and getting proper sleep--trumps all. The simple and most basic fact is (1) we...

Once we have seized control of the endocrine system, it doesn't matter.

I love melatonin. ....and it loves me.

Until I see a study that melatonin actually lowers estrogen, I will remain hopeful, but unconvinced. What we DO know is it is the most powerful antioxidant the body makes, and that would inhibit cancer growth. This may explain the study. We also see inflammatory processes increasing aromatase...

Usually that goes away with time. Also, some have found INCREASING the dose stops that. At worse, simple lower your dose.

That has nothing to do with any potential estrogen lowering property of melatonin. Has anyone seen a study that actually measured melatonin lowering estrogen?

Contend away. We like that here! I think the author of that article (by what he includes in the article.....haven't seen the actual study) is extrapolating an unsupported conclusion. The title of the article is his creation--not the name of the study. He is a good writer, though, and a good...

When evaluating a study, it's as important to know what a study does NOT say, as what it does. This study says melatonin reduces breast cancer risk. We already knew that. ...not that we can use melatonin instead of an aromatase inhibitor for TRT.

PREG is good stuff, isn't it!?

No one should worry PREG will turn into E on them. That's just not how the body works. You end up with what you end up with. The pathways are fluid and dynamic.

"IGF-1 levels (the most accurate method of determining GH levels within the body) " Not true. The 24 urine GH assay is, beyond a doubt, the most accurate measure of GH status.

Many men have testosterone that is too low, but estrogen that is higher in the range. I also see where the body has increases DHT when T is low.