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You raise some valid concerns that I would agree with.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/

JohnDoe - I'm in the 300 Total /20 E2 range...

Thanks Vince, I was curious too. I used clomid previously and that elevated my estrogen quite a bit.

Thanks Vince!

Had a phone consult with one of the docs at Defy today. I will speak with someone tomorrow about getting the prescriptions, needles and so forth. I was wondering what you would recommend in terms of needle size, syringe size, and other supplies. Also what is the most affordable way to get the...

The only study I have seen was with supraphysiological doses of T, and even then the changes in Thyroid function were small.

Test cyp seems like the most unlikely cause. Metformin and AI's are known to cause constipation. Take a fiber supplement morning and night, drink lots of water. Do you need the metformin for diabetes or is this being Rx'd for aging reasons?

Full text for those who are interested. Nelson, there is a higher hazard ratio for those at the very bottom and those at the very top. But if you look at Table 2, there is a difference in incidence rates for men (comparing <30 and >51) of ~7 / 1000 person years. I don't think this is much to...

I think the HDL woes are overblown. If you are over 40 mg/dl you are likely just fine. Most people can get there easily eating well and moving more or participating in structured exercise. HDL boosting drug trials have all failed over the past decade as they don't impact mortality. The newest...

You also have Larry Lipshultz Houston.

This sounded like hokum, but there appears to be some support for this in the scientific literature. http://onlinelibrary.wiley.com/doi/10.1002/ar.20782/full

Worth a look. https://labdoor.com/rankings/fish-oil http://www.nutrasource.ca/ifos/product-reports/default.aspx

Anyone have experience supplementing with TUDCA (Tauroursodeoxycholic Acid) to lower triglycerides or liver enzymes? Was it effective?

Vince, that is likely a function of age. The GFR declines after age 45 at ~1 ml/min.

Nice summary Will. One of the more exciting benefits extending beyond human performance is the potential protective effect in fatty liver disease. A recent review is attached for those interested...

Thank you Vince. I appreciate the info. How has your experience been with Defy? Are the costs reasonable?

Has anyone been able to locate a good doctor in the Kansas City area? I have hypogonadism, and have used clomid until now for fertility reasons. I am off clomid, but most local physicians are pushing creams or pellets - neither of which interest me. Thanks!