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The two active forms of Vitamin B12 are methylcobalamin and adenosylcobalamin. I wonder if you'd have better long-term results by adding in adenosylcobalamin supplements to your existing dose of methylcobalamin (5,000mcg)?

I don't know the answer to your fist question. But it's interesting that you responded better to Clomid than enclomiphene. What were the dosage amounts and frequency of both drugs?

Maybe intratesticular E2 is higher when taking hCG as is testosterone. In that case measuring serum estradiol wouldn’t tell the whole story.

I’d like to see what your liver enzymes look like on Jatenzo, particularly GGT.

I would encourage you to go back to a cardiologist and get checked again. If they still can’t make a diagnosis or find anything wrong, you may want to try the amino acid taurine. I have read anecdotal reports that it might help with palpitations and an irregular heart beat. But check with your...

These treatments are available in the U.S. Many doctors are doing PRP now, and my mother plans to get a stem cell injection in her knee in Florida. Look up Drew Timmermans on YouTube.

Have you tried regenerative injections such as platelet rich plasma (PRP) or stem cells?

I don’t know about the testosterone angle, but look up Drew Timmerman, ND on YouTube.

You can do it. I'm 6' 4" and 200lbs.

Unfortunately I didn't save it, but I've seen a study that indicates a body weight above 200lbs in men is associated with a shorter lifespan. The bigger you are and the more you weigh - even taking into account muscle mass and body composition - that 200 remains the magic number. Maybe it has...

I was intermittently taking 2mg of Rapamycin per week and it had a major positive effect on my physical stamina. No sexual effects at all. Unfortunately I developed a potassium deficiency while taking it that took me a long time to figure out. It was probably exacerbated by another medication...

Doesn’t clomiphene have a reputation for increasing SHBG, which would lower free? If Clomid improves BPH, then it would be more interesting if it works on the prostate directly.

Measuring serum B12 directly is not as useful as getting a blood level of homocysteine and methylmalonic acid. I have not experienced acne on cyanocobalamin injections. If you read the study I linked to above, the authors state that B12 aggravates acne. Never heard that before but it’s...

The standard dose is 1,000 mcg, or 1 ml. The frequency is up to you. I'm currently doing B12 injections once a week. Increased body temperature, fewer aches and pains, more energy, and my tinnitus (ringing in the ears) has improved slightly. No change in sexual function. Another thing to be...

Were you taking methylcobalamin by chance? I felt dreadful taking it orally, sublingually and even the nasal methylcobalamin made me feel sick. Switched to cyanocobalamin injections and it's been smooth sailing ever since.

Good for you. I noticed this “offense” culture started with overly sensitive (narcissistic) millennials and now it’s spread to all generations of workers. I get “attitude” at the blood bank. Hostility at the phone store. Even the local credit union customer rep was offended and gave me...

https://pubmed.ncbi.nlm.nih.gov/34661247/ Eur Rev Med Pharmacol Sci . 2021 Oct;25(19):5889-5903. doi: 10.26355/eurrev_202110_26865. Low testosterone levels and high estradiol to testosterone ratio are associated with hyperinflammatory state and mortality in hospitalized men with COVID-19 M...

Which cortisol tests (total, free, AM, PM, etc.) were you using?

Among many other effects, I think vitamin B12 may be acting on the hypothalamic-pituitary-adrenal (HPA) axis in some way to stimulate cortisol. Just a hunch at this point. I need to do more reading and research. BTW, you will feel like death warmed over if your serum cortisol is too low...

https://tahomaclinic.com/Private/Articles2/VitaminB12/Newbold%201989%20-%20Vitamin%20B-12%20placebo%20or%20neglected%20therapeutic%20tool.pdf

I posted a few links to studies at the beginning of this thread. For the sake of convenience, here they are again. https://pubmed.ncbi.nlm.nih.gov/34498733/ We discussed and debated about how to go about lowering homocysteine earlier in the thread. My position is that vitamin B12 drove down...

It doesn't matter if you're eating foods rich in folate, or taking a folic acid supplement - the body eventually converts it to the active form, methylfolate. In the B12 study I posted above, they don't mention methylfolate specifically, but I'm confident that a methylfolate supplement will...

Have you had a liver function panel? AST, ALT and particularly GGT.

How do you know your insulin isn’t elevated? What’s your HOMA-IR? Let me know the results of your fasting insulin test, too. Glucose clamp test is the gold standard for determining insulin resistance.

This is too complex a subject to get into here, but you need to start reading Dr. Mikhail Blogosklonny's work on how mTOR drives all aging. HGH use leads to insulin resistance, which in turn activates the mTOR pathway as a result of chronically elevated insulin levels. It's not solely insulin...

Here's another reason to be skeptical of folic acid supplementation. The MTHFR crowd, in particular, who think they're doing themselves good by supplementing with methylfolate should take note. https://pubmed.ncbi.nlm.nih.gov/34634124/ Adv Nutrition .2021 Oct 11 Perspective: The...

Human growth hormone therapy is known to increase insulin resistance. It's ironic that HGH is promoted as an anti-aging drug when it's the opposite. No doubt it makes you feel better (more energy, better cognition) and helps to reduce body fat.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093343/ I posted about this study last year, but it didn't get much attention or traction. It's interesting how 15 - 20 years go AIs were almost thought of as mandatory, and estrogen was the devil. But linear thinking takes over and now it's the...

I was thinking about changes in liver or kidney function (particularly the liver).

Is that oral progesterone compounded? You experienced any other negative side effects from taking it?

Large veins in that area near the surface.