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Missed this from my earlier reply. Yes, Dr. Saya at Defy tested sensitive e2 before starting clomid and twice while on it. And I'll test it again in a few weeks now that I'm off. E2 management is crucial when on clomid - my sensitive e2 went from 30.2 pg/mL pre-clomid to 68.3 pg/mL after about 6...

I have stopped all clomid and AI a week ago and will retest levels in about 5 weeks. I'll consult with my doctor in about 7 weeks, and we will re-evaluate. I may transition to traditional TRT, but am not sure yet. I also am having testing done to rule out sleep apnea as a potential cause of my...

I just spent over an hour chatting online with Anthem about this, and the response I got from the rep I chatted with matches up 100% with what HarryCat was told. Labcorp and Quest both submit claims showing the location of lab services as where the referring physician is located (in this case...

If that question is directed at me, about 5 months on 12.5mg ED. It caused my numbers to go through the roof, but I did not feel any better and in fact started feeling worse over the final few weeks. I also required an AI, first anastrozole and then exemestane, because it caused my e2 to...

Regarding my labs, my Anthem BCBS policy only says that "Your Plan provides Covered Services when the following services are Medically Necessary: . . . Diagnostic x-ray and laboratory procedures." "Covered Services" are in turn defined as "Medically Necessary health care services and supplies...

Thanks for this thread. So far, I have paid Defy directly for all my labs, but was considering just getting the Rx and having LabCorp bill insurance moving forward. It hit me a week or so ago that if I had been paying through insurance the same as what I've paid to Defy I would have already hit...

It is generally recommended that if you experience ANY vision changes (the most common being "floaters") with clomid that you stop taking it immediately and consult with your doctor. According to the warnings I got when I started clomid, most vision issues are temporary and will go away after...

Thanks for checking in. My consult was this morning and pleasant as always. I'm going to discontinue clomid immediately, continue the exemestane for two more doses, and then retest levels in six weeks to see how things look with clomid out of my system. My sleep study is next week, and I should...

Agree entirely madman. If body comp is the only issue, then TRT is not the answer. I only meant that when multiple symptoms are present and most other causes and treatments are ruled out, TRT might be an option worth trying even with acceptable natural levels. Put another way, OP's natural...

Yes, I am a lawyer, but I don't see how that's relevant. (See what I did there?) All kidding aside, what you said is more or less what I was trying to say in my post, but perhaps the point did not come across. I'm not trying to argue that I (or the OP) suffer from hypogonadism or clinical low...

I can relate. I'm 36, and my natural levels (as of February) are 702 total and and 17.5 free. I also can relate to your comments about body composition. I have strugged with the same. I eat at a 10-15% surplus with perfect macros and devoted commitment to tried and true training programs and...

A little over 4 months, actually, so I'm content that I've given it a chance. I still have almost a week until my next consult so the exemestane has a little more time to do its thing, but absent a dramatic turnaround over the next 6 days, I struggle to see any compelling reason to continue with...

Wishing you good results! Some certainly seem to benefit greatly, unfortunately that has not been the case for me so far. I haven't noticed any improvement after switching from anastrozole to exemestane to manage E2 better, although it has only been a week since the switch. Unfortunately, I...

Chatted with Defy a few minutes ago, and they want me to switch from 0.25mg anastrozole EOD to 12.5mg exemestane twice/week. Exemestane should arrive sometime middle of next week, and I'll make the switch. . Dr. Saya - if you happen to read this (and I should have asked Sam this question on the...

Some very quick non-scientific internet searching seems to indicate that test levels with cypionate peak 48-72 hours after injection, and with propionate about 14 hours after injection.

Glad to hear things are working well for you so far. I hope the numbers are good, but how you feel is most important. Just curious - you say you're at a 7/10 right now. What would you say was your pre-clomid beginning point?

Thanks, Dr. Saya. I look foward to hearing from them.

Posting here just to vent a bit, but I think I am pretty close to deciding that clomid just is not going to resolve my symptoms. I'm now almost 5 months into clomid monotherapy, and despite my total and free testosterone increasing dramatically and my estradiol being mostly in check (though...

Quick follow-up - I heard from the Defy medical staff today and was advised to continue with anastrozole 0.25mg EOD, so no changes there. 53 is a little high, but they believe e2 could still be in the process of coming down and stabilizing so better to leave things alone until I speak with Dr...

My latest round of labs have come back. . Testosterone, Serum: >1500 ng/dL (348-1197) Testosterone, Free (Direct): 36.3 pg/mL (8.7-25.1) SHBG, Serum: 58.1 nmol/L (16.5-55.9) Estradiol (Sensitive): 53.2 pg/mL (8.0-35.0) LH: 9.2 mIU/mL (1.7-8.6) Vitamin D, 25-Hydroxy: 63.4 ng/mL (30.0-100.0)...

Thanks, Dr. Saya.

Agree with CoastWatcher. Great attitude about it all. The path is often long and frustrating!

Sorry the clomid did not work for you, but based on those extremely high doses barely moving needle, it seems like you're making the right decision. Hope your HCT stays in check this time!

Next round of labs were ordered today, and my next consult is scheduled for July 11. Dr. Saya - if you happen to read this, when I placed the lab order, my chart did not reflect ordering another cortisol test. From your post above (#70), it looks like you wanted another cortisol test run, so I...

It's not scheduled yet. The soonest Defy will let you schedule the next consult is when you place the next lab order, which will happen later this week I think. I suspect based on previous wait times it will be late June or early July. Since everything is in flux for me, I have to wait for Dr...

It's been a few weeks since I last posted in this thead, so time for an update. Current protocol: 12.5mg clomid ED 0.25mg anastrozole EOD . Supplements: 1350mg licorice root spread over 3 doses 5000 IU vitamin D3 1000mg stinging nettle root Multivitamin (changed from previous multi that...

Good luck. It is tricky stuff. Even with my fairly dramatic increase in numbers, I still haven't really noticed much symptom improvement with clomid. With my e2 in check, I'd say I feel about 5% to 10% better than before, but overall it hasn't made as much of an improvement as I had hoped. ...

100 mg a day? Wow. That seems crazy to me. That is the kind of dosing prescribed for female infertility. I'm not a doctor, but if 25mg/day and then 50 mg/day for two months only got you from 364 to 410, it seems like you're not responding. I'd invite Dr. Saya or others to weigh in, but 364 vs...

The OP said in his original post that this was the protocol from his doctor. I think by "self administer" he means "self inject."

Got it. Thanks, Dr. Saya.

The licorice root supplement (Now Foods) arrived today, and I am utterly confused about the correct dosage. Various websites recommend anywhere from 150mg up to 6000 mg per day. I'm also reading that higher doses can both decrease testosterone and increase DHEA (I assume not results I want), in...