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If you're looking for anecdotes, I had this type of headache ramp up after starting TRT. The progression was slow enough that I didn't make the connection until much later, when I had greatly reduced the dose, and the headaches finally went away. For me even ~65 mg/week testosterone enanthate...

I assume 30 IU/liter refers to the concentration in blood. But you can refer to Figure 5 for the predicted results for various dosing protocols. For example, with every-other-day administration 1,000 IU yields greater testosterone production than 500 or 2,500 IU. The absolute numbers are...

It's worse than this. This work demonstrates that testosterone production follows an inverted "U" curve as a function of hCG dose; testosterone decreases when hCG gets too high.

A possible contributing factor is variations in SHBG. Testosterone therapy tends to reduce SHBG, so during treatment you likely had fairly low levels. During the hiatus SHBG probably rebounded to normal or even high levels. This is relevant, because SHBG acts as a storage reservoir for...

It's unclear what he's thinking. Taking Clomid with TRT may increase estrogenic activity via the zuclomiphene, which could cause some effects, good or bad. However, you're unlikely to see a reversal of HPTA suppression, i.e. a recovery of LH/FSH production. To me your lab results look typical...

As I recall, you have been employed by Maximus. If this is still the case then I think it should be disclosed when you're promoting them in this manner. I'm not questioning your objectivity, and I have also had favorable things to say about Maximus. However, disclosing the affiliation is the...

For sufficiently fast action, testosterone nasal gel in the form of Natesto is the only medium that has solid research behind it. However, it's possible that other forms of testosterone behave similarly. The most promising alternative is buccal troches.The pharmacokinetics appear to be similar...

One more reason why ExcelMale is better than the rest. In my experience, reasonable criticism of sponsors is tolerated. Less criticism is needed when the sponsors include quality organizations such as Defy Medical and Maximus — but I have offered modest criticisms of each without any interference.

And? Free testosterone is driven by dose. Your dose is very high, therefore your free T is very high. They are wrong about SHBG, as it tends to increase with age. And they are flat-out wrong about free testosterone, repeating a myth that won't die. Don't make the same mistake. I challenge you...

Going strictly by half-lives, DHT is between testosterone and estradiol. Wiki says the elimination half-life is 53 minutes. This doesn't imply a very big delay unless there are indirect effects via 5α reductase.

Vince, you've been around long enough to know that lowering SHBG activity is not going to raise free testosterone. However, in a case like this, if high SHBG is causing problems directly then effectively lowering it could help, at least in theory.

Because your free testosterone looks to be adequate I do not think conventional TRT passes the risk-reward test. Be skeptical if anyone pushes this on you. That said, there are some suggestions in the literature that high SHBG can impair androgen signaling. A relatively safe way to test this...

I'm not sure I have enough data to say anything definitive. My estradiol measurements were more consistent with frequent injections of enanthate, such that, for example, I could say with reasonable certainty that hCG use increases the E2/T ratio. However, with a propionate blend the measurements...

This has to be an oversimplification at best, because the half-life of estradiol in plasma is less than two hours. A better case might be made for effects on aromatase, which presumably occur over a longer time frame. It appears that androgens increase aromatase expression, while estrogens have...