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Agreed! I didn't realise he was taking the D. For sure, stop this.

Good idea seeing your doc. It is somewhat common for females to get migraines around their menstrual cycle. It is believed that the headaches may be triggered by a drop in estrogen levels around their cycle. I see no reason why males may not have the same mechanism - ie, if you drop your...

I am betting on the AI as the source of the headache. The headache itself can raise your pressure. But, the reverse is also true: elevated blood pressure can cause headaches. Let us know how your appointment goes.

Did you feel better than on Natesto alone? How long after your Natesto dose was this blood draw?

Reasonable logic. Appreciate your thoughts.

@RobRoy, if you are still around, I have questions: TLDR: If I were a patient of yours and told you most forms of TRT cause me headaches and sometimes migraines, how would you advise me? For further color, I hope you are willing to read below. I have zero interest in DHT and/or estrogen...

You are correct. No one "should" struggle. Unfortunately, people do.

These are great points. Finding the root cause is always preferable to starting supplementation. Also, nothing reproduces the natural endogenous production of testosterone. Some people have difficulty with adding it exogenously. That’s why forums like these exist.

Look, man, I am not trying to be argumentative. I didn't realize this thread had a contentious history until I looked book at old posts. My intention is not to revive all that. I am literally looking for answers. I am a long time struggler on TRT for various reasons. I want to feel good, and I...

Good suggestion. I have already considered this. I was only doing one click on the scrotum. I don't think half clicks are very consistent. So, I would have to get a different strength cream. I happen to have 20% and 15%, so I could drop the dose by changing the cream. That said, I decided to...

Anything is possible, but it doesn’t seem logical that the anastrozole would have the cardiovascular effects I experienced. Androgens, on the other hand, are well-known to do this. I am open to your explanation if you have one.

Good stuff. I didn’t read the entire JCEM paper, but it looks like a good design. Randomized and double-blinded. That said, the study population was hypogonadal, but not under treatment. So, like you pointed out, the findings may not translate in those with HPTA suppression. The reason I asked...

Since i consider myself both mature and intelligent, this should be no problem!

Since I am getting crickets on the above question, I'll ask another one: do we think anastrozole indirectly increases DHT? I found one paper that says yes, but is this generally accepted as true and reproducible? @madman, can you help me with a forum search question? I tried putting in the...

For any cream users, has anyone found better success applying to non-scrotal areas? I spent about two weeks applying some to the scrotum and some to the shoulder. I wound up with a number of terrible symptoms that convinced me I was way supraphysiologic. I am not sure I am ready to throw in...

Really what I was asking is the logistical nature of how you apply it if you are in your work setting. Wasn’t really asking about timing or dosing. Based on your comments above, I suspect you are not applying it in the work setting, but are doing it when you get home. Natesto is incredibly...

Appreciate the thoughts. But, you didn’t answer me, brother!

Gents, for those of you who are applying cream twice a day, I am curious how you go about your second application? If you still in your work setting, do you sneak off to a bathroom and toss the stuff on? I suppose this would be easier if you are doing scrotal, cause you just gotta drop your...

My intuition tells me that secondary is more common than primary because of our unhealthy society. Does anyone happen to know? Just curious.

Very solid advice.

Estradiol is a bit of a flashpoint in the TRT world. Some absolutely are adamant that men should not be messing with aromatase inhibitors to try to bring levels down. Others swear that they feel bad when their levels rise above a certain threshold. I tend to fall in the latter category. I think...

If you don’t know your estradiol level, I’d recommend getting it checked with an ultra sensitive test and report back here. Lots of possibilities, but excessively high testosterone levels and/or estrogen levels can both cause what you are describing.

What is your estradiol level?

My advice: figure out what symptoms you are trying to correct and look long and hard issues other than hypogonadism that might be causing them. Then, look at all the lifestyle changes you might be able to make to improve your natural production. If you go down this road, consider the least...

Estradiol was 46 on the above regimen. A lot of guys feel fine with levels a lot higher than this. I believe I feel bad at this level. I suspect that if I had the same amount of testosterone with lower DHT and E2, I would not have felt as bad as I did. I also suspect scrotal application may be...

I would drive yourself to an inpatient facility right now. Do not delay. You need help.

Hey, man. You may have missed it, but somewhere above, I have some questions about your early cream experience. You said you struggled early on. In what way? Was your struggle lack of efficacy (ie, low T symptoms brought forward), or did you struggle due to side effects (ie, new symptoms from...

I was using 20% strength. 50mg scrotal/50mg shoulder in the AM, then 50mg shoulder in the PM. Trust me, brother - I want it to work! No question you are correct on letting the esters clear. I'd consider trying it one more time down the road. That said, I alluded above to a certain kind of bad...

I (kind of) agree that three days is insignificant. But, I think waiting six weeks for labs is more applicable to esterified forms of testosterone with long half lives. Cream has a quick onset and short half life. That said, three days is by no means 5-6 half lives it might take to reach a...

So, I have never pulled labs while on cream. Finally I went ahead and got some labs. Was on cream for about three days and felt absolutely horrendous the whole time. Thought it would be useful to see what my labs look like while feeling like this. Long story short, free testosterone was a touch...

I also happen to be on Accutane at the moment. I suspect on Accutane probably has some negative G.I. impact. I would like to give Jatenzo another try once I’m off Accutane in about three weeks. If so, I will report back.