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@readalot and I have been discussing SSRI's in another thread, so I thought I'd move it over here. I started sertraline 50mg for four days followed by 100mg for the last few weeks. So far, the biggest challenge has been crushing fatigue in the middle of the day. It starts around 11 AM and...

I do feel less anxious (I am also tightly wound). But, the fatigue is unacceptable for me. Maybe with time it will subside? For now, I am actually titrating down - primarily to troubleshoot the cause of the fatigue with the idea that I can always go back up and/or restart. Some say the combo of...

I'll dig in. Thanks. Mood was one of the many symptoms I have been trying to "treat" with TRT. As is well documented, I have had a hard time nailing down a tolerable TRT protocol (@Charliebizz, hold your fire, my brother ;)). So, I decided that maybe I should be attempting to attack mood from...

I actually may consider this, too. Any idea why Lexapro would be useful for this as opposed to any other SSRI? Any unpleasant side effects from it (I know it can be associated with emotional blunting, libido, drop, etc.)?

Nebivolol is supposed to have less sedating and libido affects. It might be a good option if you have those side effects. Reasonable to ask your prescribing physician, particularly since you are on an ARB.

I think this is more common than we think. I have experienced it as well. The few things that were helpful: Using Natesto or using a beta blocker with your current protocol. Beta blockers are great drugs, but for some, they can come with unacceptable side effects (lethargy, depression, libido...

It’s theoretically possible that the preservatives are causing a problem, but unlikely. One way to test the theory would be to Xyosted. It does not have preservatives. It would be an expensive experiment if it’s not covered by insurance.

Yes. Cream and I have a bit of a love-hate relationship. It can be a wild pony to tame, but for many, it’s an excellent treatment option. If you’re not careful, you can skyrocket your testosterone and DHT level with cream. But, it still may be worth trying. If you can get a compounded cream...

This should definitely be taken seriously. Get a high-quality cuff for home. Measure it a few different times during the day and do that consistently and record the values. If you are seeing it that high on a consistent basis, you should press your primary care doctor to address it.

I experience similar sensations, depending on what form of TRT I am using. You might consider trying a different form or changing up the dosing and/or frequency like others suggested. This tends not to be an issue for me with things like Natesto. It’s worth trying something else such as a...

That’s a hotly debated topic.

Are you having high estradiol symptoms? If so, what are they?

So, to be clear, you are or are not using cream?

I’ve used it on and off for years. I can bore you to death with details. Bottom line is I think for it to work, you have to give it time and be patient. It’s the least likely to cause side effects, which is great.

Not really. If I apply it to my arms in the morning, I get dressed, go to work and I'm covered. My understanding is that transference is unlikely beyond several hours. Edit: sorry - I just saw this question was not for me!

Interesting. Same DHT levels? What were they?

Those that switch from cream to injections seem to be guys that don't absorb cream well. It appears that you absorb it well. So do I. In fact, I am trying cream again right now. My issue is figuring out a way to not absorb too much. There are various reasons why a guy may switch from injections...

@Cataceous, I read either in this thread or another one that you tried transdermal and had disproportionate conversion to DHT. Were are you applying to scrotum or extremities? Also, do you have any way to make an educated guess as to how long it might take DHT to normalize if you were using a...

What dose and where were you applying? How many times a day? I recently posted my labs on a somewhat modest dose on the scrotum. Labs were crazy out of whack. Lots of people have gone from cream to injections and vice versa.

The IM arm of the study is a pretty archaic protocol. That said, this is an important find. I‘d love to see more guys try Natesto - in particular guys who can’t dial in on anything else.

My intention in posting my original labs was not to blame E2, but just to provide information and feedback to the community at large. I do think elevated E2 gives me problems. I’ve experienced it before. That said, I believe the substantial elevation of testosterone, and all the associated...

My free T was double the high end of normal. Maybe some can tolerate that, but I definitely cannot.

I am not disagreeing.

I actually am fairly confident that I do not tolerate even moderate elevations of E2. I have lots of labs that correlate with feeling shitty and I have lots of anecdotal experience with using an AI and pulling myself out of a dump with it. I get it - there are lots of reasons why an AI is tricky...

Yes - I was titrating my dose. I had no intention of doing it forever. But, with a short acting agent, I think it's reasonable to play with the dose a little in the beginning before you settle and stick with something. My intention was to settle on the 100mg scrotal AM and 50mg PM. But, I felt...

I was on TRT the whole time. I’ve only been off for two weeks, so skin is still dry, but I do think the oil is starting to come back. Will give an update in the next few weeks if you want. As far as musculoskeletal pain, that seems to be mostly improved. Not perfect. But, I’ve also skyrocketed...

I just finished about six months. I had a ton of musculoskeletal pain while on it. Random places at random times. Impossible to say if it was accutane, but I am glad I am off.

My newest cream seems "wetter" than my prior cream. That said, the prior cream is a few years old, so maybe it dried out.

For anyone curious about whether or not scrotal cream is efficacious, please read below: Context I used cream on and off for three weeks. I varied dose, location and cream strength (15% and 20%) to find an ideal protocol. Seven days prior to labs: Day 1 AM - 112.5mg shoulders PM - 50mg...

I agree with @sammmy. I’m pretty confident that if you lower your dose, your symptoms will subside eventually. I doubt it’s related to iron.

Update?