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Many claim that frequent injections miimic natural physiology better than infrequent injections, but this doesn't seem accurate. Younger men have a daily variation in testosterone levels. Some guys might feel better on less frequent injections for this reason. There are many stories of men...

What's crazy is the 2009 law change to the "biologics" classification was designed to lower prescription drug prices. That was the entire point of its inclusion...

I was told by my clinic they can’t even send me compounded testosterone in California anymore. I hope they were just misinterpreting the HCG decision, because that would be pretty crazy.

Do we know what ruling, law, etc made this happen? When I contact my representatives I’d like to have a concrete change to point to. I even went through and watched hours of the CA State Board of Pharmacy meeting videos, read their minutes, etc. I can’t find any change that would have led to this.

Here's an older post on this topic - https://www.excelmale.com/forum/threads/what-is-the-highest-testosterone-level-for-long-term-health.6354/ There are also risks with not feeling that good, not being as good at your job, not being as good of a partner or a parent as you could be. There are...

According to this post on reddit, Defy just told their California patients that compounded HCG is no longer allowed to be shipped to or produced in California. This is nuts! Does anyone have any details? What are the relevant laws / codes here? I will write to some of my elected...

Looking at the numbers (n=220 for the statin-induced myopathy symptom alleviation groups) - very small N. You can see from the wide confidence interval of the muscle pain analysis - this result was "not significant" but likely underpowered. So it is "not significant" but that does not rule out...

My HDL-C lowered slightly. I don't think it is clinically meaningful - in the context of heavy anabolic steroid abuse, where HDL-C may be in the single digits - I do think it may be showing something pathological. I am obsessed with CVD health and listen to lipidology podcasts, etc. I have...

How soon after a protocol change do you think it’s acceptable to get blood work done if someone is doing subQ testosterone injections? I usually use SteroidPlotter - Graph your cycle, but it sounds like this should be adjusted for subQ if it does have a 50% greater half life.

To address sirgawain's question more directly - There is strong evidence[1] that testosterone treatment improves age-related libido loss in men. The men in the studies that this evidence is based on did not use an aromatase inhibitor with their therapy. So if you are struggling with libido...

I get the rashes too - or at least I did when I was taking lots of HCG. I could slightly scratch myself and write letters on my stomach - red marks would stay there for minutes. Wearing a scarf around my neck would leave red marks. Was pretty weird. I think it had to do with a soap or shampoo I...

I've performed the Quest lab on the same day as Labcorp (about 20 minutes apart). Here is an example result: Quest: Testosterone: 1010 ng/dL Free T: 189.2 pg/mL (Range: 35.0-155.0 pg/mL) ("Dialysis") Labcorp: Testosterone: 912 ng/dL Free T: 21.7 pg/mL (Range: 8.7-25.1) Based on this result...

I stopped HCG about a month ago when there was a shortage. I plan to take just testosterone for a little while (several months) to see how I do on a simple protocol. The main problem I have with HCG is a sense of inconsistency. Sometimes I really feel the HCG in a positive way (libido...

Looking at the data in this paper, there is no statistically significant difference in total testosterone, free testosterone, SHBG, LH, or FSH between the two groups. The marker used, INSL3, was 0.59 (0.45 - 0.72) versus 0.39 (0.24 - 0.62) [past users]. Given that the other biomarkers showed...

For what it's worth: Same day, 15 minutes apart: Quest: 189.4 pg/mL (Range: 35.0-155.0 pg/mL) Labcorp: 21.8 pg/mL Six days apart, same protocol: Quest 155.4 pg/mL (Range: 35.0-155.0 pg/mL) Labcorp: 10.4 pg/mL (Range: 8.7 - 25.1)

One thing that's remarkable about the video is the line: "Starting therapy at testosterone level 15 nmol/L (432.63 ng/dL) - too late..." Compare that to the attitude from many physicians these days who refuse to treat even profoundly hypogonadal, symptomatic men.

You should not do this alone or you may pass out and bleed to death.

My firsthand, unscientific reports: Before I was on TRT, taking even a small amount of DHEA would make me feel incredible. "Like the first day of summer" is the best way to describe it. I haven't really experimented with DHEA in a controlled fashion since being on TRT. I did an experiment...

I don't think I've ever had problems with low pressure in the HCG vile (Empower HCG, if it matters). With my testosterone, I inject several (5 or so) syringes worth of air when I first break the seal on the vile. This seems to help speed up the draw into my insulin syringes.

I find it much easier to draw the testosterone first. With testosterone, there's always bubbles I like to move around and then push out of the syringe after drawing. If I draw HCG first it makes it much more difficult to do that, so my dosing of testosterone ends up being less accurate.

I will post some long, detailed updates once COVID-19 has settled in March/April (my estimate). I have been consumed with COVID-19 research. I believe that, as Nelson says, androgens themselves lead to water retention. Make sure you know your true free T - get one of the high-quality free...

How much did you increase your testosterone dosage by? By my records, HCG might be contributing anywhere from 200 to 400 ng/dL to my total testosterone (!), though I suspect my results are unusual.

The exact same thing happens to me. I’ve only ever used Empower HCG. It’s like I feel better than I ever have in my life for a few days and then it disappears. I thought it had to do with bottle freshness, but haven’t been able to find a correlation there. I mostly notice it when I stop HCG for...

I may try something like that when I re-add HCG in the future. The problem for me is that HCG requires refrigeration, and so daily usage limits my independence. Thanks for the cialis tip Nelson. I will try that soon. I get leg cramps that make it difficult to sleep when I try cialis but...

I have another update on this. Due to COVID-19, I've cut both my testosterone dose down and eliminated HCG. I wanted a very simple protocol with little risk of health downsides over the next several months, and I'm willing to be slightly more sluggish, etc in return. My current COVID-19...

I am most excited about the trials of ARBs such as Losartan. 9 clinical trials of these drugs are now starting. Here is a writeup on one at University of Minnesota: University of Minnesota Launches COVID-19 Clinical Trials of Blood Pressure Drug Losartan Mechanism described a bit here...

I once accidentally had two testosterone labs drawn at the same time from LabCorp. One came back at nearly 200 ng/dL lower than the other!

They're not on TRT, so their HPTA is intact. Thus AI lowers E2 -> hypothalamus senses less E2 -> more LH, FSH released -> more T/E2 produced.

If I was in your shoes, this is what I’d do. Get the better test and print out the results for your doctor to make it really easy. If he’s a good (which in my mind means understanding rather than infinitely knowledgeable) endo as you say then it should be straightforward from there. I don’t...

How much does it increase your total T / free T?

Here was my quick, imperfect comment on the FDA site. It would be good if others could share theirs here too so people can have material to work with: I've been using b-HCG for the past 18 months to maintain my fertility. My b-HCG comes from a 503B compounding pharmacy (Empower Pharmacy)...