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Poor metabolic health is a major risk factor for prostate cancer, which results in high levels of insulin (one of the most potent growth factors for cancer), inflammation, etc. https://pubmed.ncbi.nlm.nih.gov/38260162/ TRT is not. Men with active prostate cancer are even being treated with TRT...

I don't know why. It's possible that many people feel at least slightly worse with many supplements but are not monitoring their well-being closely enough to notice. These are often small magnitude effects that could be lost in the ups and downs of normal life. Even when the effects are...

Do they? I've never heard of any. There's nothing allergenic in there for the immune system to react to.

The individual vendors post their test results in the respective places where they advertise and interact with customers. I can link you to a more general thread about readalot's efforts to encourage more comprehensive testing: Readalots Enhanced Testing

I have some peak levels from an overdosed pharmacom prop (I was running 25 mg a day of something labeled 50 mg/mL but I think it was actually 100 mg/mL based on labs) and some peak levels from 30 mg daily of a correctly dosed prop. I'm not going to get into the details at this time, except to...

Various UGL sources. Readalot has been doing a remarkable job encouraging some of them to improve their testing. Between purity, metals, sterility, and now endotoxin, there's more documentation available for some of these UGL products than you can get from Empower or other pharmacies. They also...

What's the longest you've stayed on propionate? I experienced overstimulation followed by an evening crash in early days with prop, but it eventually went away. IME, the fully-adapted-to-propionate state is superior to the same point in an enanthate protocol, but I know everyone reacts...

You have concocted quite an elaborate narrative here. In practice, when people stop enclomiphene, their levels quickly revert back to their original baseline. Any receptor sensitivity changes that may have been caused by enclomiphene do not endure.

Fair points on high dose TP still being strongly suppressive of HPTA. The fact remains that it feels better for most people at any given dose than similar dose of long esters (even when doses/levels are "absurdly" high). What do you think the mechanisms are for that?

It is certainly this - the only doubt surrounds the exact mechanisms, whether it be effects on dopamine receptor sensitivity, less HPTA suppression near the trough, giving tissues a break from constant high levels, etc. There is no doubt though that greater fluctuation is what causes "better...

I try to use it at least a couple hours before "activity". It starts working quickly though, certainly within an hour, and probably peaks at around 3 hours. It isn't a game changer, but it can be a significant boost to libido and probably more so erectile function and orgasm intensity.

Pregnyl is renowned for being the strongest available hCG, so yes, it being stronger than USP is my guess to explain your reaction.

There is no settling it, because people have unique and unpredictable reactions to IM vs SC injection, in terms of absorption, aromatization, and symptoms. Every individual will need to try both methods to determine which is preferable for them. There is no other way. Like MegaTurd above...

How have you been using it? How much, applied where, and how many times per day? I have the alphagels 20% DHT gel also. Currently, I've just been using it on an as-needed basis for sexual enhancement, 1 ml on my abdomen, a couple hours ahead of time.

My to-try list if I were you would include everything I mentioned above that you haven't messed with yet: prop, cream, pregnenolone, lower frequency on long ester (try once weekly).

Actually, I started on Vitamin D recently and paid closer attention this time, and yeah, I think it does reduce libido. Wtf? Many people on reddit complaining of the same. Some theorize it relates to increased serotonin activity - ChatGPT also proposed serotonin modulation as a possible...

Do you mind sharing which indian pharm source has it this cheap? I'm seeing more like $4 per 200 mg tablet at alldaychemist.

How is your metabolic health? Fasting glucose, hba1c, fasting insulin (most important)? Body fat %, blood pressure?

Prolactin is barely out of range, and this is pretty common in men on TRT who are often functioning well sexually. If you want to prove or disprove that prolactin is a problem here, you can try p5p and see if it helps. Progesterone, when it isn't the LC/MS version of the test, picks up random...

Can you give us some background on how and why you arrived at this protocol? What else have you tried and what were the results? More important than the lab values you've shared, which are not a cause for concern IMO.

Not really - I have just about a year of 140 - 210 mg test weekly. I ate the worst form of processed crap SAD diet from childhood until age 25, and I've had some off-and-on positive autoimmune antibodies like ANA, rheumatoid factor, and anti phospholipid antibodies, which would be expected to...

Yes, I think this is the clearest evidence that there is more to the story than cholesterol. On the same theme, with the PSCK9 inhibitors, researchers are debating whether there is a small reduction or an increase in mortality associated with these drugs which obliterate LDL levels. There would...

Wow this is a good book so far! I'm about one third through. Thank you for the recommendation. I'm in kind of a similar boat as Stoak, with an 18.9 calcium score at age 44, which puts me in the 78th percentile. Of course, my PCP says that's great and didn't recommend I do anything about it. I...

What stretches did you do?

Yes, I also know this guy you speak of. Lol. Good advice on testing.

Rational decision for those who are comfortable managing their own protocols.

Same libido crushing with the curcumin and zinc. I don't think I noticed anything with vitamin D though. Impressive awareness of the NMDA antagonism angle on this. Not many people know anything about it. I think this is how magnesium also interferes with libido.

In theory, yes. Try it though, assuming you are susceptible to acne, and see what happens.

I have no idea. Studies report estradiol suppresses sebum production by countering androgenic activity in sebaceous glands. On paper, it should prevent acne.

In some men on TRT, yes.

There are independent contributions to water retention from both testosterone and estradiol. The rhetoric that only one or the other is responsible is false. Reducing E2 is a legitimate and effective way to reduce at least some of the water retention. This is blatantly obvious to anyone that...