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In another thread about metformin I started, I had some helpful suggestions to look into thyroid. At the time, I'd had two prior tests during the last 6 months, and was advised here on Excelmale things were worse than I thought. Looking into things away from the standard clinical approach, I...

At some point I recognised that caffeine was no longer doing anything subjectively rewarding, but somehow didn't consider removing it completely. Maybe I was seduced by all the touted health benefits. I've always know instinctively that something related to my adrenal function was being...

My libido has remained good, but nothing dramatic like the first experience. There are too many variables in play for me anyway. I've added things like adding B12 and benfotiamine and have completely cut out caffeine since starting with the stack. I've also added my arginine and citruline...

I wanted to know if there was anything in Chandler Marrs story on metformin, referenced earlier in this thread. I did a bit of reading and posted a point of view to the original thread.

Old thread I know, but I think there is room to question the story of the article. If it was all true, shouldn't we expect more evidence of real world outcomes with all the millions taking it? At least she begins by declaring her preemptive distrust. I find it misleading to mix together known...

I have some HCG but I am hesitating. Does anyone know for sure that what applies to arimidex, in not inhibiting aromatase in the testes, also applies to exemestane?

We are going around in circles a bit, but who knows maybe concentric ones. I think any reasonable person would argue what you refer to as shoddy science, wishful thinking, etc has it's place in the scientific process. Your use of such sweeping pejorative terms looks to me like a smoke screen...

The lack of evidence statement can be justified easily when you control the threshold for what constitutes evidence in the same statement. The lack of clinical trials can and often does stem from a lack of financial incentive rather than the lack of prospect for greater good If I control my...

My use of metformin is 100% off label. Hopefully that should be clear from everything I've put in the thread, but I'm happy to answer any specific questions. I am satisfied I have done my homework on the risks and benefits, again happy to discuss. I do not encourage people reading this to...

Metformin and its gastrointestinal problems: A review Seems it's not so rare to not have any reaction. GI symptoms Percentage Diarrhea 62.1% Heartburn 52.1% Nausea 47.4% Abdominal pain 35.5% Bloating 35.2% Retching 21.1%

Back on topic.. I took 250mg metformin yesterday morning in a well fasted state. No GI issues. Followed up with 250mg after evening meal. This morning, I upped it to 500mg fasted. Again, no GI reaction whatsoever. I'm on the non-XR ones. Either I'm not in the affected group, or I have...

Looking further, there are some reports of libido impact form l-carnitine which I hadn't seen before. Also seen reports that for people with hypothyroidism, which it seems includes me, l-carnitine can be quite helpful in terms of energy. Incidentally, I think the fact of drinking an acid...

I just want to say thanks to everyone who offered their time to help me. Especially Vince Carter and captain who made me understand the scale of my issue. Steep learning curve. I have read hundreds of pages since I started this thread. I find my self shocked again that I reached 47 without...

Thanks JimBob. The main point I've picked up from this is something I heard Jay Campbell mention: dessciated thyroid. I had meant to follow this up and find out whether he took it for hypothyroidism or as an adjunct to TRT. Quick read, but here he seems to say as an adjunct: Is Thyroid...

I am in the UK. From what I understand, with the NHS, they start with TSH and T4 only. Then they will maybe do antibodies, and apparently T3 is not usually offered. I could shorten the process by convincing them I've got TSH and T4 results already.

Apparently the antibody test is occasionally misleading because of level fluctuations, and this could also apply to TSH testing. Anyway, I've found a private test. Looks like it has everything but reverse T3: Thyroid Check Plus | Thyroid Function Blood Test | Medichecks.com captain I hear...

Belief is not involved. I am in the gathering material stage, and no conclusions have been reached. It doesn't take much research to understand this is a polarising subject. 'my take' was arrived at by encountering a number of references stating that TSH between 5-10 and T4 in range is...

Hashimotos is associcated with h pylori: The association of Helicobacter pylori infection with Hashimoto's thyroiditis. - PubMed - NCBI Metformin is associated with inhibition of h pylori: Metformin can inhibit Helicobacter pylori growth. - PubMed - NCBI

No I took iodine after seeing the TSH results Reading around earlier, my take is that 5-10 TSH is subclinical, especially with the T4 in range, albeit low. I read more than one study that indicates a single figure percentage rate of progression to full blown hypothyroidism. I read other...

I gave the first try out to a new supplement stack, which apart from creatine which I take every day, contains things I have either taken sporadically or not at all. Each was selected for it's own supposed benefits, and I thought of making up a single bottle with the following and about 500ml...

Even more intrigue, there seems to be a different pathway for metformin interaction with thyroid hormones: Metformin and the thyroid: An unexplored therapeutic option Kalra S, Dhamija P, Unnikrishnan AG - Thyroid Res Pract If I understand correctly, metformin lowers tsh, but not in isolation...

Taking the conversation full circle, since many sources claim metformin promotes healthy gut bacteria, and gut health is implicated in hypothyroidism by some, is it a stretch to ask if metformin might even help? Rand Mcain, Jay Campbel and Nelson all seem to say that people with GI distress...

Damnit, which is it? Cortisol raises TSH: ELEVATED CORTISOL RAISES TSH LEVELS - The Conscious Pod Cortisol lowers TSH: Cortisol and Thyroid Hormones | Hypothyroid Mom

Seems like a good piece in the puzzle captain, thanks. Reading around it now, but I recently self diagnosed (rightly or wrongly) lifelong high cortisol, and subsequently introduced ashwagandha, and the impact has been clear and undeniable. I am a different person on ash. I also switched from...

There is so much conflicting information out there on this. Taking my numbers alone having read further it seems I have 'subclinical hypothyroidism', and I do see that the other tests will shine more light on what's behind it. So I will take the tests, although I've been reading that UK docs...

Any thoughts on the T-nation mantra of take a sh*t load of iodine?

Interesting, so if I understand, thyroid imbalance is a potential root cause for resistant fat, low t like symptoms, and relates to SHBG levels. And SHBG levels CAN relate to insulin resistance? Is it circular? For instance If I managed to shed the gut, aromatise less and lower my insulin...

I am lead to believe that other things being equal there will be an average of 6lb over the first year. What I am thinking though is it might be different if you are pushing the diet and exercise but not seeing results from it. I am glad you asked Vince. When I got labs from my TRT provider...

Hi, I would say after 6 months on TRT I am close to dailled in, or at least the best I've been. Pre-TRT and during TRT I've had periods where I've trained every day, seen my strength and fitness go up (benching bodyweight, squad and deadlift 2x bodyweight, completed tough mudder, found it...

I have carried on with 5mg per day and no more strong heart beats. It's bringing back memories of being younger. I was almost late for work today because I had to wait for morning wood to go down before peeing. Apologies for TMI.

I have to admit I didn't stick to the plan. The more I read the more it made sense to start on 5mg daily. I have taken 10mg a few times before with no sides. Maybe I got a bit impatient. This is day 3 now. Yesterday I became aware of my heart beat a few times. Heart rate is in the same...