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    A human trial of oral BPC-157 was quickly canceled

    A Phase II study for BPC-157 in the form of enemas for Inflammatory Bowel Disease was started in 2002 and again radio silence after that, no results published, no phase III study initiated, which means they did not like the result or have safety concerns...
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    A human trial of oral BPC-157 was quickly canceled

    They did not need it to absorb. It was a pre-trial for for BPC-157 in Ulcerative colitis, which requires topical action, not absorption. Yet nothing published in 8 years except some poster in Digestive Disease Week 2023 that few can access: https://adisinsight.springer.com/drugs/800006013
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    A human trial of oral BPC-157 was quickly canceled

    BPC-157 and its drug delivery variations have quite a few patents already. If there was a "lack of funding" then they wouldn't start a Phase 1 trial and complete it, which is extremely cheap in Mexico. Since the trial was completed and the results not published, the only logical conclusion is...
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    A human trial of oral BPC-157 was quickly canceled

    The fact that they did not publish any result and did nothing for 8 years after the trial in 2015 means that the drug company thinks the drug is not marketable or has safety concerns. This is the usual history of failing drugs.
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    A human trial of oral BPC-157 was quickly canceled

    Phase I, pilot study in healthy volunteers, to assess the safety and pharmacokinetics of PCO-02, which active ingredient is BPC-157, a pentadecapeptide from gastric source. Conducted in 2015. Canceled in 2016 with NO EXPLANATION - either not effective or dangerous...
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    Oral BPC-157 For Potential Gut Health

    And the sales representative keeps spewing nonsense "studies" from Croatia or China ... Promoting VEGFR by BPC-157 is begging for cancer: https://www.sciencedirect.com/science/article/pii/S1044579X22000670 "Body Protective Compound" it is NOT! That is why the team in Croatia is afraid to do a...
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    Oral BPC-157 For Potential Gut Health

    And here is my anecdotal evidence. In 2019/2020 wasted my money on 15mg BPC-157 for gastritis, oral administration. No noticeable or lasting effects on irritated gastric mucosa. I literally can't find a single report of someone that cured an ulcer or gastritis with BPC-157, in 30 years!, despite...
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    Oral BPC-157 For Potential Gut Health

    I already posted some anecdotal reports that BPC-157 isn't the miracle that Badassblues claims it to be. More anecdotes can be found with Search on this forum. Badassblues posted actually links to a site selling peptides, trying to pass this as "research", and claims BPC-157 is "safe and...
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    Oral BPC-157 For Potential Gut Health

    More actual posts reporting that BPC-157 did not deliver the claimed benefits: https://www.excelmale.com/forum/threads/bpc-157-tb500.23060/#post-267273 So much about the disconnect between reality and marketing hype that some are attempting to create here. Use the Search people and save your...
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    BPC-157 and Cancer

    Unproven safety in humans is the main concern with BPC-157. There are no studies probing the potential of bpc-157 to exacerbate tumor metastases, not even in mice. The compound was discovered in 1993 in Croatia and for 30 years there isn't a single study in humans, which makes me think they are...
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    Oral BPC-157 For Potential Gut Health

    From now on, I am reporting any such blatantly advertising posts with "articles" from sites selling peptides. Moreover, any time someone does that, I will post an ANTI-advertisement with anecdotal reports that show the stuff they are promoting does not work and is a waste of money. Let's see...
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    Oral BPC-157 For Potential Gut Health

    Here is something of value for your advertisement department. No matter how many promotional "studies" you post to boost sales, the lack of positive anecdotal reports is glaring. A few hundred $$$ on the "miraculous" BPC-157 did not help tendonitis...
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    Oral BPC-157 For Potential Gut Health

    I don't see any evidence in your posts that BPC-157 is safe and effective for humans. All you posted is promotional mice studies from Croatia and infomercials from sites selling it. If you don't have an actual proof it is safe and effective in humans, please take your advertisements to another...
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    Oral BPC-157 For Potential Gut Health

    Most of the promotional marketing studies of BPC-157 come from Croatia. That makes me think they have a financial incentive. Also, despite many studies with rats, they are afraid to do a single human study in 30 years. Is it because they are not sure the stuff is safe and do not want to bear...
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    Oral BPC-157 For Potential Gut Health

    Marketing articles on sites that sell peptides are not a proof that a peptide is safe or effective. Regarding BPC-157, human studies are missing, mice studies of the potential to promote tumor spreading via angiogenesis are missing, anecdotal reports that a single ulcer was healed are missing...
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    Oral BPC-157 For Potential Gut Health

    Despite all the hype coming from Croatia, where the peptide was originally made in 1993, no proof of safety and efficacy in humans to this day, 30 years later. Not a single HUMAN study of intestinal ulcers healing with BPC-157 and these are not that expensive to do. The burning question is why...
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    "TRT/HRT/Nutrition/Cognition/Wellness/LT student of the game"

    Vit C is Ascorbic Acid and exacerbates gastritis - very clearly in my case. If you eat sufficient green salads, green or red peppers, and/or fruits, you don't need to supplement. The "buffered" salt forms or the liposomal vit C are less irritable to stomach mucosa but still irritable. I get the...
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    Testosterone Side Effects after one year.

    You could drop to 50-60 mg/week and see if that improves the sides. Remember when you measure your T at trough before the next shot, your T can be lower than the middle of the normal range because it is your lowest level, not your average.
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    "TRT/HRT/Nutrition/Cognition/Wellness/LT student of the game"

    Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis
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    "TRT/HRT/Nutrition/Cognition/Wellness/LT student of the game"

    Any stimulant in small doses has a positive effect on memory and cognition, which is interpreted that it is "neuroprotective". That doesn't mean it cures or prevents dementia in the long run. Nicotine can potentially predispose to vascular dementia by the negative effects it exerts on blood...
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    "TRT/HRT/Nutrition/Cognition/Wellness/LT student of the game"

    Science is corrupt in many ways. The claims that nicotine reduces the risk for dementia were actually promoted by tobacco companies I think in the 1980s but turned out to be the opposite of truth. Of course you can do whatever you want if it helps you, just don't trust some doctor on internet...
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    "TRT/HRT/Nutrition/Cognition/Wellness/LT student of the game"

    You simply got high on nicotine. Nicotine is not benign to the blood vessels and long term use is not advisable. Smoking actually is associated with a higher risk of dementia so it is not supporting the claimed "benefits". People that get better on it are benefiting from the stimulating effect...
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    Anyone have Covid and measure their coagulation/clotting factors?

    There were athletes getting a heart attack post covid from a blood clot. They too felt fine, until they didn't. Don't play with something you don't fully understand and don't assume the aticoagulant makes you invincible to that. Until your D-dimer normalizes, you should not do anything strenuous.
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    Anyone have Covid and measure their coagulation/clotting factors?

    https://www.cureus.com/articles/117503-a-case-of-deep-vein-thrombosis-after-recovery-from-covid-19-and-its-association-with-elevated-d-dimers#!/
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    Anyone have Covid and measure their coagulation/clotting factors?

    Most probably remnant from Covid. I would take it easy until clotting normalizes - no strenuous exercise or cardio of any kind, just walk and eat less calories. I would also stop enclomiphene and similar TRT and maybe consult someone how to reduce D-Dimer. Check also your CBC to see the status...
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    In the search for libido: Started Flibanserin

    I can't sleep long or deep when I eat too much sugar during the day, even in the form of fruits. Keep in mind that sleep is affected not only by drugs but also by stress and diet.
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    Need libido/dysautonomia help please read entirely!

    https://www.healthhub.sg/a-z/medications/fludrocortisone-for-low-blood-pressure
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    Need libido/dysautonomia help please read entirely!

    Cortisone is used to increase blood pressure in rare cases of low blood pressure. It does that by increasing the blood volume i.e. it draws more water in the blood circulation. Larger volume in the vascular system leads to higher blood pressure.
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    "TRT/HRT/Nutrition/Cognition/Wellness/LT student of the game"

    Try a banana before meal to coat the stomach. It might help with the post-meal headaches - it did in my case. I changed to Omeprazole from Rabeprazole and no more headache. Rabeprazole almost made me sick again - no clue what the mechanism is. Because Rabeprazole is one of the strongest PPI per...
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    "TRT/HRT/Nutrition/Cognition/Wellness/LT student of the game"

    Rabeprazole PPI can cause headaches as a side effect. I wondered what caused the severe headaches when I did my H. Pylori eradication. I suspected Metronidazole but it could have been the Rabeprazole PPI. I switched yesterday to Rabeprazole and today have some headache only after 3 doses of...
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    "TRT/HRT/Nutrition/Cognition/Wellness/LT student of the game"

    The PPI is to combat the remaining nausea which I suspect is due to remaining gastritis. I am also test driving the PPI to see if it will improve my constantly hoarse voice - it doesn't. I suspected an acid gastric reflux causing the hoarse voice but since it is not improved by the PPI, that...
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