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  1. S

    Sex hormone signaling and regulation of immune function

    So the AR inhibit most of the immune system, except B cells. I get latent herpes activation (headaches and cold sores), every time I boost free testosterone (with arimidex, HCG, or Androgel). That made me stop.
  2. S

    First post. Can’t get E2 under control, starting to worry

    Drop your T dose to 40mg twice weekly (80mg/week) and your estrogen will drop too. Some members here do 40mg/week so you will be fine.
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    Low T?

    I would stop all supplements to make sure they are not causing the high LH and FSH. If these high levels are due to "natural testosterone boosters", they must be at toxic levels to produce such high hormones. After that, go to endocrinologist to get tested for primary hypogonadism (testicular...
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    First post. Can’t get E2 under control, starting to worry

    What is the normal range of your e2 test for males? 240 to 275 is a normal random fluctuation since you were taking the same amount of arimidex. This is not a significant increase.
  5. S

    First post. Can’t get E2 under control, starting to worry

    It seems your arimidex is fake. Where do you buy it from? The best way to reduce e2 is to reduce the T dose and drop the HCG and then the arimidex may be unnecessary.
  6. S

    Low Free T

    The most efficient course in your case is to test your blood pressure at home (morning before breakfast and evening before bed - the evening will be lower) on the current low dose TRT. If it's normal, drop the blood pressure medication for a few days and retest: it is normal if it stays 120/80...
  7. S

    Low Free T

    This is your time line gathered from your previous posts. Correct anything that is wrong: 1. You started TRT 8-10 years ago due to low T symptoms - sexual and body composition. My guess is that you were low normal free T, like me. You felt your symptoms drastically improved on TRT but did that...
  8. S

    Low Free T

    How long have you been on TRT and what benefits do you experience from it? Did you have low normal free testosterone before TRT? Were you put on blood pressure and cholesterol meds after you started TRT?
  9. S

    Low T?

    The first thing to do is to repeat the test, this time with SHBG and Comprehensive Metabolic panel (for Albumin), so you can calculate the free testosterone. You may be having high SHBG and low free T. Low T is not the only possible cause of erectile problems.
  10. S

    Low Free T

    Bing Copilot on statins' effect on sexuality: Statins, which are medications commonly used to lower cholesterol, can indeed have an impact on sexual health. Here are some key points: 1. **Erectile Dysfunction (ED)**: Statins may potentially improve ED, as high cholesterol is a critical risk...
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    Low Free T

    ChatGPT (Bing Copilot) gives summary that is much different from your doctor: Blood pressure medications can indeed have an impact on sexual health. Here are some key points: 1. **Erectile Dysfunction (ED)**: Erectile dysfunction is a common side effect of blood pressure medications¹. Over...
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    Low Free T

    Your doctor pretends he knows more than he actually does. Blood pressure meds and statins DO affect sexuality.
  13. S

    Low Free T

    What is your current diet and exercise? What body fat? Weren't you on some form of TRT 2 years ago? Why did you stop?
  14. S

    Post meal chronic fatigue

    I used AbsorbAid enzymes (plant based), which was the first thing that definitely helped my post-meal symptoms. Later I switched to prescription enzymes Creon (raw pig pancreas). After I did antibiotics for H. Pylori, I found out that I no longer needed the enzymes - the antibiotics cleared...
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    Post meal chronic fatigue

    Another thing to check is your blood pressure after meals when you feel worse. If it drops significantly, this is called post-prandial hypotension. It is a sign that the nervous system is damaged (dysautonomia) and cannot control the blood pressure well. Or it could be happening because you have...
  16. S

    Post meal chronic fatigue

    I've had isolated episodes of post-meal hypoglycemia and it was making me hungry and nervous with shaking hands, not sleepy. Your symptoms do not match that, but if you want to test for that condition, get a blood glucose meter and measure your blood glucose 2-3 hours after meal. I used to have...
  17. S

    Anyone got hair laser removal here?

    Plus the laser is shooting at random so they can't really ramp it up to kill every area in site. Electrolysis really targets a single follicle and can remove the hair permanently but I think it may leave scarring and must be done hair by hair.
  18. S

    Anyone got hair laser removal here?

    The laser burns the black hairs but for safety reasons is not powerful enough to kill the hair follicles. It just partially damages them, which delays the hair growth.
  19. S

    Anyone got hair laser removal here?

    It just slows the hair growth, has to be done indefinitely, and works only on black hairs, not on gray or white. Basically, it is an expensive, long term shaving. I had a session on beard under chin - it left out the white hairs and the black ones grew up later.
  20. S

    Hcg and headaches

    It seems that you have a parallel problem and your TRT is just amplifying it. Have you done a CBC test to see what your immune system is doing?
  21. S

    Anyone tried sublingual PT-141 and/or oxytocin??

    I've tried nasal spray Oxytocin. It made reaching orgasm easier but impaired erection - I've seen studies that it leads to release of adrenaline. The effect on social anxiety or "bonding" is negligible and overhyped in the "research". I've tried Oxytocin compounded trochees - zero effect on...
  22. S

    Inverse Relationship between HGH and SHBG

    If your trigs are still sitting at 30, check yourself for hyperthyroidism - it can cause low triglycerides because the body is burning them too fast. It is not normal for a diet loaded with carbs like bread for the trigs to be in the 30s. Low fat diets also cause low trigs.
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    Inverse Relationship between HGH and SHBG

    Low carbohydrates is not the only possible cause of low triglycerides: https://www.healthline.com/health/low-triglycerides#causes
  24. S

    Inverse Relationship between HGH and SHBG

    https://www.healthline.com/health/low-triglycerides
  25. S

    Inverse Relationship between HGH and SHBG

    Your 2022 and 2023 triglycerides are too low, which suggests starvation (not enough carbs are eaten or processed), which could explain high SHBG. It would be wise to retest triglycerides to see why your recent 2024 result is different and which value is the norm for you.
  26. S

    Inverse Relationship between HGH and SHBG

    What is your fasting Triglycerides blood level?
  27. S

    Bloodwork After 7yrs Self-Administered TRT

    Are your depression, brain fog and lack of focus improved on such large T doses? If not, why do you keep doing it? You are still injecting too much testosterone which causes all kinds of side effects. Go for 60-80mg T/week and split it in two doses to avoid large peaks. Too much testosterone...
  28. S

    5 Years Hypogonadal, nothing works. Looking for any insight

    TRT resolving your bone pain does NOT mean the origin of pain is lack of hormones. Testosterone can be immunosuppressive and reduces inflammation. Excess Testosterone will simply override the underlying problem, doesn't mean the problem is lack of testosterone. Your reasoning resembles "taking...
  29. S

    5 Years Hypogonadal, nothing works. Looking for any insight

    The problem is that it "doesn't walk like a duck". Not every sexual problem is related to low T and you had trough Testosterone >1500ng/dL and some high normal values on TRT, which didn't resolve any of your problems. You could try low normal doses of TRT like 30mg T, twice per week (60mg...
  30. S

    5 Years Hypogonadal, nothing works. Looking for any insight

    Your problems do not seem related to T deficiency, since you have tried rather high doses TRT and no symptomatic improvement. It is time to accept that TRT is not the answer to every problem. The current medicine does not understand well the origin of venous insufficiency - which in my case is...
  31. S

    Stop Using Mouthwash And Dental Hygiene

    Unlikely a mouthwash in your mouth will affect nitric oxide production in penis. I personally stopped using mouthwash and commercial toothpaste because they give me hoarse voice from irritation. Baking soda and hydrogen peroxide do the same. I currently just salt my toothbrush and it removes...
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