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22 years...

Tetrahydrobiopterin = BH4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215290/ BH4 metabolism can instead be depicted as a cytoprotective pathway that is finely regulated by the concerted action of de novo, salvage, and recycling pathways to regulate intracellular concentrations of BH4 and...

Great post!

Once you start down the path of TRT, you are altering your natural balance. That is a good thing for those who need it, and a very unwise move for those that don't. Your labs look great, don't start tinkering with your hormones as it will not likely lead to a positive place. Loss of libido and...

What He^ said. Any doctor that saw those labs and prescribed you testosterone should have his license revoked.

The cream penetrates the skin and is absorbed. Once absorbed, it works within the area you placed it. I have found a rejuvenation effect from using Andractim years ago. You would definitely wash it off prior to sex.

I do put a little on the big guy, but for the libido bump, the taint works best. I'm not after penis growth, but a little on the frenulum does increase sensitivity.

I am going to stay on cypionate as my main TRT protocol for now until I find a better source for propionate. I will use the propionate on weekends and other special occasions. The same for the DHT. I hate to repeat myself, but as stated above... I work for a living and I can't be that...

I am using 20 mg Sub Q of the propionate in the AM. I apply a dime sized drop of the DHT cream to the "taint" area. I use PhloJel as a base and it dries pretty fast. We were discussing the peak of propionate a while back, my best guess as to that after using it is 5 hours. By 1 or 2 O'clock, I...

I am not going to keep this as a routine, it will be more of an "on demand' type of thing. I'm, not exaggerating when I say it's a major distraction to be teenager horny when trying to work ;) I do believe it's the combo however, DHT cream increases my libido a lot and is consistent. The...

If anyone has been following the other threads regarding DHT cream and Test Prop, you will know the discussion of libido has been mentioned. I recently ordered some test prop and have been using it the past few days. I have also dialed in my DHT cream home brew to a very nice end product. I do...

I have never tried Proviron, so I couldn't give any kind of opinion. I would like to at some point. I can tell you however, that the libido boost and the mood enhancement from the topical are nothing short of fantastic (for me). It's a little annoying at times when I am working or doing...

The interesting thing to me was that the highest incidence of prostate cancer is in hypogonadal men.

DHT sources in the prostate Although DHT enters many tissues through diffusion from the systemic circulation, DHT in the circulation does not diffuse into the prostate because DHT concentrations in the prostate are markedly higher than the systemic circulation (intraprostatic DHT is on average...

Association of Circulating Levels of DHT and DHT/T Ratio With Prostate Disease Although androgens support the growth, proliferation, and progression of aggressive prostate cancer, there is no consensus that elevated levels of circulating androgens contribute to the risk of developing prostate...

Serum DHT and DHT/T Ratios in Men After Transdermal DHT Administration Data regarding the clinical impact of sustained supraphysiologic concentrations of DHT in men repeatedly exposed to daily transdermally administered DHT gel provide valuable clinical safety information. Here we summarize the...

Binding affinity for AR Binding of T and DHT to the androgen receptor (AR) stabilizes the AR and slows what would otherwise be rapid degradation. At low circulating androgen levels, DHT binding is favored over T but at higher relative T concentrations (e.g., eugonadal state), stabilization of...

Figure 1. Metabolism pathways for deactivation of DHT to inactive glucuronides. Enzymes and genes associated with pathways are noted next to arrows. Relative thickness/size of arrows represents primary direction of reaction. Compiled from (6, 7, 8). 3α-DH, 3α-dehydrogenase; 3β-DH...

DHT is the 5α-reduced metabolite of testosterone (T) that is principally converted from T in target organs such as prostate, skin, and liver. Synthesis can also occur from other precursors, but these pathways, although potentially important in some tissues (e.g., in prostate), are minor...

I have recently resumed using topical DHT. It has been a few years since I have last used it and the concentrations are now higher than before. Naturally, I was curious as to any implications this may have on prostate health. Research has uncovered some fascinating information...

Fatigue and low energy are some of the most reported ailments people suffer from. Due to the large number of reasons that a person may have these symptoms, it's extremely difficult to pin the root cause down. As prevalent as this virus is, a person reporting these symptoms should be tested for...

The MAJOR factor for success in taking LDN is getting proper sleep, I mean DEEP sleep. The drug works while you are sleeping, any disruption of your sleep cycle will result in the symptoms you mentioned above. If you have to, take something to help you sleep through the night. Interestingly...

For clarification, the discussion of selegeline is on topic with this thread as it is a potential solution to the problem... ;)

Some things that potentiate the effects of selegeline for me in a negative way are stimulants. Caffeine, energy drinks, tyrosine and others have to be moderated or I get overstimulated.

I am fortunate enough to have an open-minded physician who has prescribed me selegeline. It's worth a shot for any who are interested to ask your doc for a script. Take your research in and show them, do your homework and know that this is a small dose that will not effect MAO-A. If they...

I personally take a 5 mg tablet daily. Some are using a liquid form from what I have heard, but there are conflicting opinions on that. A good description of the benefits is here: https://www.antiaging-systems.com/articles/deprenyl-50-years-of-life-enhancement-and-life-extension/

The dosage for health extension purposes is very low, 2-5 mg's. I have seen no reports of any ill effects after discontinuation.

I have stopped selegeline in the past several times with no ill effects.

Selegeline does not increase dopamine levels directly, it acts on the enzyme that degrades dopamine which keeps it active for a longer period of time. I have seen nothing to indicate that it has any effect on norepinephrine. The main thing with selegeline at low doses is that it only has an...

P5P is vitamin B6, 5HTP is a serotonin enhancing supplement, very different. Wellbutrin does indeed disrupt sleep in some as it can greatly enhance the action of norepinephrine. Agitation and anxiety are common, and dose dependent. I could only tolerate 150 MG of the extended-release tablets...

I have had similar experiences with Wellbutrin (Bupropion), although somewhat short lived. Wellbutrin works mainly by limiting the reuptake of norepinephrine and to a lesser degree dopamine. Both are crucial for orgasm. Not everyone responds to this the same way however, some experience anxiety...