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Ah shit, sorry to hear that it doesn't work well. Idk what the protocol would be. Still trying to figure it out. Do you perhaps feel shittier after a certain food or supplement?

Hm, still worth trying to see if there is a difference. Huh, it's interesting that anhedonia is better when on short esters. I wonder why that is. But it has been reported before ...

I'd like to see your e2 levels before injection. Hm, oral e2 very quickly converts to other forms of estrogen. Did you try crushing the pill and putting it under tongue yet - so sublingually?

I see. Hm, interesting. But look - 14 june your e2 is very high. So we can suppose that your aromatase is OK. EDIT: Oh, did you mean that 500mgs test was keeping your e2 at 35 without AI?

Yeah, I had to end my relationship because of this, fuck me. The regret is real. So I sympathize. You might want to explain your situation to your gf. Ultimately you're digging yourself a bigger hole under your feet with tren. So I don't think the lack of aromatase is the problem. Coconutz...

Sorry, not sure if I understand: what was your TRT dose at this point? Also, what was your aromasin dose when you noticed symptoms? Stop daily cialis or reduce to 2.5mg EOD. It has AI properties. Caber might not be necessary without tren. But it might be necessary with oral e2 pills. I'd reduce...

I would try to avoid tren. It binds to both progesterone and glucocorticoid receptors, likely upregulating AR (androgen receptors) via weaker glucocorticoid receptor binding (AR and GR are in tight interaction) and downregulating ER via progesterone activity. Proviron also upregulates 5AR due to...

Hey, do you mind sharing in clear detail how this started? So you were doing how much test per week before the crash? And how much aromasin and proviron were you using? Also, have you been using tren at the time when you crashed? What is your protocol right now? And what are your symptoms beside...

Thanks for answering. Do you take any supplements? Also, have you taken any antibiotics or stuff like that before the crash?

You mentioned a lot of symptoms but what about these: - gut issues (bloating, excessive burps/farts, stool appearance etc.)? - dry mouth or eyes? - ED? - joints clicking/squeaking and/or aching? - muscle twitching? - how does the anxiety present itself physically? Also - do the symptoms get...

If it is any consolation, you're not alone. There's about a dozen people on this forum who reported long term AI induced low e2 symptoms. Hopefully we can eventually figure out how to resolve this. As of now, there have been some positive reports on e2 supplementation (oral e2 and injectable...

Hey man, sorry to hear that. I'm in a similar boat. Do you mind sharing in detail as much of the relevant info as possible? Which AI you took, what protocols you've tried, blood/urine test results etc.

Get yourself some iron bisglycinate. It's quite possible that your issues are entirely due to very low ferritin. It needs to be above 100. Cholesterol is an issue as well but ferritin seems to be a bigger problem.

Do you perhaps make your own topical finasteride? If so - what's the "recipe"?

@Nocalves Thank you for your informative reply! Okay, new questions are here (when you'll have extra time to answer, haha): 2. So you didn't notice any difference between injections, pills and creams for progesterone in terms of symptoms? They all decrease E2? I ask that because some people...

Can you upload the latest blood work? If it is possible just add images of all the values. Some people react quite negatively to the slightest raises in prolactin in terms of libido and drive. Hcg increases it. It did mine quite significantly. I wonder where your progesterone levels sit at...

@Nocalves Hi, thank you very much for answering. My issues also started with aromasin and are to a noticeable extent still ongoing. I have not yet managed to get injectable E2. Will do soon. I'd like to ask you a few questions - maybe we can figure this out together. 1. Blood work shows DHEA...

Interesting, thanks.

How was your E2 (and TT) when you were putting it to the thighs?

Things to consider: - potential history of SSRI use; 5ARi use (finasteride) - progesterone, dhea, pregnenolone supplementation - gut health (bowel movement frequency, stool appearance) - overall metabolic, mitochondrial health, immune system function (notice any infections anywhere on the body?)...

Which nootropics have you used?

That's quite a fucked-up story, man. Sorry to hear all that. Your resiliency is inspiring as well. Your health issues are likely too complicated for this forum. I think you'll find useful information on the discord server I've sent to your DMs. It primarily focuses on resolving...

What kind of nandrolone protocol have you tried? Also, have you attempted adding exogenous E2?

Yeah, estrogen (but not dht) influences the production and composition of synovial fluid, its viscosity and quality. This is crucial for proper joint lubrication and overall joint health.

Oil-producing glands, or sebaceous glands, are not found in the joints. Primarily in skin. DHT does possess anti-inflammatory properties and can play a role in maintaining joint integrity but estradiol seems to play much bigger role in keeping the joints healthy.

Joint and libido problems are associated with low e2. I wonder if exogenous e2 would alleviate long term accutane induced symptoms.

I'd be very much interested to see blood levels (instead/on top of urine levels) of the tested hormones. Is it possible for you to get some blood work done?

Have you tested your SHBG levels?

Oh, not OP, just entered the convo. But yeah, looking for the root cause for a while now.

25. My TSH levels are hovering around 3-3.7 for more than a year now. 3 docs, of those 2 endos, told me it's ok since it's within range. But ever since covid I've been dealing with low libido, worse EQ, gut issues etc. so I've been now suspecting that thyroid is at least part of the problem...

How would one go about optimising thyroid aside from the usual supps (selenium, iodine, iron etc)? With meds?