Rethinking Oral TRT with KYZATREX®

madman · Jun 25, 2025

Modern patients want simple, effective treatment options.

KYZATREX® offers oral testosterone therapy with proven efficacy—and none of the mess, pain, or liver strain of older options.

.Join Dr. John Mulhall for a deep dive into the science and patient selection for KYZATREX®.

John P. Mulhall (Andrologist/Urologist)

madman · Jun 25, 2025

Evolution of Testosterone Therapy

madman · Jun 25, 2025

KYZATREX® (testosterone undecanoate) CIII Capsules

madman · Jun 25, 2025

Unique Formulation

madman · Jun 25, 2025

Pharmacokinetics: Plasma T Profile

madman · Jun 25, 2025

Safety Profile

madman · Jun 25, 2025

Economic and Practical Considerations

madman · Jun 25, 2025

Managing Patient Expectations

madman · Jun 25, 2025

Thread 'KYZATREX (oral testosterone undecanoate) Updates'

Oct 16, 2022

KYZATREX™ (testosterone undecanoate capsules)

The Power of Hormonal Balance | Restore your T- levels with Two KYZATREX capsules a day. | Discover KYZATREX Rediscover CONFIDENCE | A solution sans needles, gels, or creams

www.kyzatrex.com

KYZATREX (testosterone undecanoate) is an oral testosterone replacement therapy specifically designed for adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as primary hypogonadism and hypogonadotropic hypogonadism 11 12. Here is detailed information regarding its dosage, usage, side effects, price, and efficacy:

Dosage

KYZATREX is available in capsule form in three dosage strengths: 100 mg, 150 mg, and 200 mg. The recommended starting dose is 200 mg...

madman · Jun 25, 2025

Thread 'Oral Testosterone Therapy in Men with Low Testosterone: A Comprehensive Review'

Nov 17, 2024

Introduction

Background and significance

Hypogonadism, characterized by low testosterone levels, is a significant clinical condition affecting a substantial proportion of the male population, particularly older men. The management of hypogonadism often involves testosterone replacement therapy (TRT), which can be administered through various routes, including intramuscular injections, transdermal patches, and oral formulations. While injectable and transdermal options have been extensively studied, oral testosterone therapy, particularly using testosterone undecanoate (TU)...

MJ65 · Jun 25, 2025

madman said:
Thread 'Oral Testosterone Therapy in Men with Low Testosterone: A Comprehensive Review'

Nov 17, 2024

Introduction

Background and significance

Hypogonadism, characterized by low testosterone levels, is a significant clinical condition affecting a substantial proportion of the male population, particularly older men. The management of hypogonadism often involves testosterone replacement therapy (TRT), which can be administered through various routes, including intramuscular injections, transdermal patches, and oral formulations. While injectable and transdermal options have been extensively studied, oral testosterone therapy, particularly using testosterone undecanoate (TU)...

madman

hypogonadism; tth; oral tu; safety/efficacy

Replies: 16

Forum: Testosterone and Men's Health Articles

Does it increase DHT levels more than injections or cream?

madman · Jun 26, 2025

MJ65 said:
Does it increase DHT levels more than injections or cream?

Transdermal scrotal application, standard application (arms/shoulders/abdomen), oral TU (Jatenzo, Tlando and Kyzatrex), injectable.

Scrotal apllication would take the cake!

Also need to keep in mind dose let alone if you are one who would be considered a high converter T--->DHT.

* The rates of conversion of testosterone to DHT and E2 vary among people due to polymorphisms of genes that encode the steroid 5α reductases and the aromatase enzyme as well as other host-specific factors that affect the activity of these enzymes

Thread 'Higher Estradiol, T and DHT correlated to higher libido in older hypogonadal men than T alone'

Feb 10, 2022

Relation of Testosterone, Dihydrotestosterone, and Estradiol with Changes in Outcomes Measures in the Testosterone Trials (2022)
Alisa J. Stephens-Shields, PhD, Peter J. Snyder, MD, Susan S. Ellenberg, PhD, Lynne Taylor, PhD, Shalender Bhasin, MB, BS

Abstract

Context. Many effects of testosterone are mediated through dihydrotestosterone (DHT) and estradiol. The relative contributions of each hormone to the observed effects of testosterone remain incompletely understood.

Methods. Using data from the Testosterone Trials, we assessed the association of...

*Circulating testosterone is converted in many peripheral tissues to its two active metabolites, 5α dihydrotestosterone (DHT) and 17β estradiol (E2)

*In many androgen-responsive tissues, a family of steroid 5α reductase enzymes converts testosterone to DHT, and the aromatase enzyme, a product of the CYP19A1 gene, converts it to E2

*Many tissue-specific biologic effects of testosterone are mediated through DHT and E2

*The rates of conversion of testosterone to DHT and E2 vary among people due to polymorphisms of genes that encode the steroid 5α reductases and the aromatase enzyme as well as other host-specific factors that affect the activity of these enzymes

*It is not known how the circulating concentrations of testosterone’s metabolites – DHT and E2 – modulate the effects of testosterone on various outcomes and how their circulating levels rank in their contribution to the observed effects of testosterone treatment on physiologic outcomes