Cialis can lower estrogen, increase hepcidin and hinder iron absorption.

Systemlord · Feb 14, 2024

I noticed shortly after starting daily Cialis, within a week, my iron supplement requirements increased, and have been increasing exponentially (out of control now) ever since I started taking Cialis 6 months ago.

Since stopping Cialis it appears I'm having to back down my iron dosage back to where it was prior to taking Cialis.

This could be a reason why Cialis would seem to stop working for some men.

17β-Estradiol Inhibits Iron Hormone Hepcidin Through an Estrogen Responsive Element Half-Site

Interaction of estrogen with iron at the systemic level is long suspected, but direct evidence linking the two is limited. In the present study, we examined the effects of 17β-estradiol (E2) on hepcidin, a key negative regulator of iron absorption ...

www.ncbi.nlm.nih.gov

Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element

Iron is essential for the human being, involving in oxygen transport, energy metabolism and DNA synthesis. Iron homeostasis is tightly governed by the…

www.sciencedirect.com

Systemlord · Feb 15, 2024

Well two days after stopping 5 mg Cialis, my emotions are back, gone is the emotionally flatness. I think it's safe to say over the 6-8 months on 5 mg daily Cialis has crushed my estrogen.

I have been peeing a lot, clicking, popping knees, and ED which is now reversing.

I may restart at 2.5 or even 1 mg.

Keepfit1 · Feb 16, 2024

Systemlord said:
Well two days after stopping 5 mg Cialis, my emotions are back, gone is the emotionally flatness. I think it's safe to say over the 6-8 months on 5 mg daily Cialis has crushed my estrogen.

I have been peeing a lot, clicking, popping knees, and ED which is now reversing.

I may restart at 2.5 or even 1 mg.

did you do any before and after labs to confirm your suspicions?

Systemlord · Feb 16, 2024

Keepfit1 said:
did you do any before and after labs to confirm your suspicions?

I don't see any need to tested estrogen. It's obvious that long term Cialis use has lowered my estrogen and affected my iron absorption. I noticed at first things were fine, but over time I started having issues.

Stopping Cialis has reversed many of the symptoms I was having.

I do believe the effects on iron homeostasis was my bigger issue versus the low estrogen. I didn't feel as if the estrogen was super low but low enough to blunt my emotions, libido and erectile function.

HSLD · Feb 16, 2024

I've been taking 5mg daily for about 6 years with no issues. E2 is always elevated, similar to what it was before starting daily tadalafil.

n=1

t_spacemonkey · Feb 16, 2024

that might be of value for men with high e2? i like this drug if not the nasal congestion that comes with it. add a cannabis edible to the mix at night, and breathing is hard having to use various decongestants....

Vince · Feb 16, 2024

Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study - PubMed

Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen-estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil...

pubmed.ncbi.nlm.nih.gov

Weasel · Feb 16, 2024

So tadafil could potentially help raise ferritin?

Systemlord · Feb 16, 2024

Weasel said:
So tadafil could potentially help raise ferritin?

That's what happened in my case, I increased the iron intake, also the iron is stored in the tissue surrounding the fat tissue and not available for the body to utilize.

My gums swelled up, blisters in the gum tissue, pain in teeth, joints, muscles, hot flashes burning, sensations all over my body.

Systemlord · Feb 17, 2024

Nevermind, I found out my real problem. I'm vitamin D deficient, serum level 17, down from 28!

That's why I require more iron.

I wonder if the vitamin D deficiency has anything to do with my strange response to Cialis. Maybe vitamin D is needed for Cialis to do its thing.

NitricOxideNutritionDoc · Feb 18, 2024

I like to see my patients with 25-OH levels between 60 and 90 for optimal health.

Systemlord · Feb 18, 2024

NitricOxideNutritionDoc said:
I like to see my patients with 25-OH levels between 60 and 90 for optimal health.

I am a hyper responder to a lot of stuff. I can’t handle a vitamin D level 30> which causes extreme nausea, bone pain, pain in penis, problems breathing and dehydration.

I start getting significant hearing loss at 35, I have to blast my car stereo to 100% just to hear it.

Are you adjusting your vitamin D intake to account for the Fall/Winter months of limited sunlight exposure?

I went to urgent care today with all too familiar symptoms, they had been creeping up on me gradually over the last couple of weeks. Revisit 2019 and I had multiple deficiencies, vitamin D being on of them. A vitamin D deficiency is devastating for anyone with diabetes as it makes managing...

www.excelmale.com

Systemlord · Feb 18, 2024

I just started taking 600 IU gel capsules yesterday after seeing the labs.

I took a 5 mg Cialis dose today and didn’t have a bad reaction like I did days ago.

The vitamin D drops I got off Amazon 2 weeks ago is a fake product.

Gladiator · Feb 26, 2024

Systemlord said:
The vitamin D drops I got off Amazon 2 weeks ago is a fake product.

You been taking sugar tablets?

I had vitamin D level of 15. It was so bad. I was suicidal.
Now my level is above 100.

t_spacemonkey · Feb 26, 2024

I ran 50k IU for months. blood levels 200ng/dl. felt great. now back to 10k. also feeling great. it really seems that the sweet spot for many is 60-100ng/dl which typically is a 5-10k IU dose

Systemlord · Feb 26, 2024

Gladiator said:
I had vitamin D level of 15. It was so bad. I was suicidal.

Vitamin D3 is a nitric oxide regulator, which is how Cialis works, so it’s not hard to see why Cialis doesn’t work when vitamin D is low.

My erections are returning, stronger than before.

DorianGray · Feb 26, 2024

Cialis hasn't seemed to improve my ferritin. Still low and I have normal to high iron levels. (genetic Fe variants)

Cialis can lower estrogen, increase hepcidin and hinder iron absorption.

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