Bloodwork After 7yrs Self-Administered TRT

I will try and keep this short. I was diagnosed with low T back in 2023. After 3 years my clinic shut down and I decided to go UGL until this month. During those 7 years, my protocol was 200mg test C a week broken down to 2x weekly sub Q injections. No HCG and no AI. Since then I have been diagnosed with Bipolar / Manic Depression and put on antipsychotics and antidepressants. 2 months ago I lowered my dose to 150mg a week.
I have attached my recent bloodwork and as you can see my E2 is pretty high. Since then I have signed up with a new clinic and have been put on Test C 120mg a week to be broken down into 3 weekly injections. 500iu HCG 2 x a week and .25mg AI 2 x a week. I have also donated a power red at the Red Cross to try and bring down RBC and HCT.
Do you think that the high E2 can be the cause of the manic depressive diagnosis? I do have an appointment with my Physiatrist next week to discuss this. I also have a Uborligist appointment to review PSA results.

manny816 said:

I will try and keep this short. I was diagnosed with low T back in 2023. After 3 years my clinic shut down and I decided to go UGL until this month. During those 7 years, my protocol was 200mg test C a week broken down to 2x weekly sub Q injections. No HCG and no AI. Since then I have been diagnosed with Bipolar / Manic Depression and put on antipsychotics and antidepressants. 2 months ago I lowered my dose to 150mg a week.
I have attached my recent bloodwork and as you can see my E2 is pretty high. Since then I have signed up with a new clinic and have been put on Test C 120mg a week to be broken down into 3 weekly injections. 500iu HCG 2 x a week and .25mg AI 2 x a week. I have also donated a power red at the Red Cross to try and bring down RBC and HCT.
Do you think that the high E2 can be the cause of the manic depressive diagnosis? I do have an appointment with my Physiatrist next week to discuss this. I also have a Uborligist appointment to review PSA results.

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Sorry, the original diagnosis was in 2013

As far as the hematocrit, if you're having sleep problems, get a sleep study done asap, because TRT can worsen sleep apnea.

Your Free T is high, you can expect high estrogen and I wouldn't expect any other outcome.

Sometimes men are overly sensitive to androgens, over-responders, you can expect a big increase in hematocrit from baseline.

What was your baseline hematocrit?

You need to find out why PSA is elevated.

Systemlord said:

As far as the hematocrit, if you're having sleep problems, get a sleep study done asap, because TRT can worsen sleep apnea.

Your Free T is high, you can expect high estrogen and I wouldn't expect any other outcome.

Sometimes men are overly sensitive to androgens, over-responders, you can expect a big increase in hematocrit from baseline.

What was your baseline hematocrit?

You need to find out why PSA is elevat

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Everything is ok as far as sleep goes. My baseline hematocrit was high at 47.6. My main issues have always been mental sides, depression, lack of motivation, brain fog, and lack of focus.

Are your depression, brain fog and lack of focus improved on such large T doses? If not, why do you keep doing it?

You are still injecting too much testosterone which causes all kinds of side effects. Go for 60-80mg T/week and split it in two doses to avoid large peaks.

Too much testosterone can act like a stimulant and lead to anxiety, aggression, and paranoid tendencies, as is typical for any stimulant.

I think you should reduce your dosage as you may be an over-responder to androgens.

Repeat you labs first. If your h/h remains that high look into donating ONE TIME a unit of blood….if anyone will take you. I may be too high to donate. I hope your blood pressure is ok. Explore why your PSA is high also. Then consider daily sub q micro-dosing. Your a1-c is high normal so watch your simple carb and sugar intake.

Olddragger said:

Repeat you labs first. If your h/h remains that high look into donating ONE TIME a unit of blood….if anyone will take you. I may be too high to donate. I hope your blood pressure is ok. Explore why your PSA is high also. Then consider daily sub q micro-dosing. Your a1-c is high normal so watch your simple carb and sugar intake.

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5.2 is fine. Yes, some have an a1c that's lower. Don't scare OP.

tropicaldaze1950 said:

5.2 is fine. Yes, some have an a1c that's lower. Don't scare OP.

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Agreed. 5.2 is actually a great A1c value. That paired with a 60 triglyceride level tells me this guy is insulin sensitive, and doing a pretty good job diet wise, overall, and without even knowing what his diet looks like, I can tell u he’s eating healthier than most are. Most people would kill for his A1c and triglyceride levels

i'd be careful with antidepressants and especially AP's which are nightmare drugs. they can cause tardive dyskinesia, which most of the time is irreversible and according to some doctors occurs in 50%!!! of the patients (despite pharma saying its 'low')
also AD's are a nightmare to come off and some people take years to recover. there is little evidence that they actually work past the placebo effect as well.
throwing someone on AI out of the box, especially on 120mg/week is bullshit. my e2 runs at 70-80 and i feel good on it
i ran test with AI's and it never made a difference. i don't think that your 'diagnosis' is hormone related. in fact most so called psychiatric diagnosis are a scam to begin with, and are purely observational.
good luck

Thanks guys, don’t mean to cause any anxiety, and that is why I did say high normal. 5.7 for his laboratory is pre diabetes and it would be wise to keep an eye on it since his is 5.2. Heck everyone (me especially) could probably benefit from watching their simple carbs and sugar intake. Sorry OP I hope I didn’t cause any worry. There is no need to be worried about your A1C.

Olddragger said:

Thanks guys, don’t mean to cause any anxiety, and that is why I did say high normal. 5.7 for his laboratory is pre diabetes and it would be wise to keep an eye on it since his is 5.2. Heck everyone (me especially) could probably benefit from watching their simple carbs and sugar intake. Sorry OP I hope I didn’t cause any worry. There is no need to be worried about your A1C.

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No harm no foul lol. Ur only looking out for OP. I get it. 5.2 does seem close to 5.7, relatively, and 5.7 is pre-diabetes, so again, 5.2 doesn’t seem too far off and might seem like cause for concern. But even full carnivores tend to have an A1c in the 4.8-5.2 range, and they’re as insulin sensitive and non-diabetic as u can get. So 5.2 is definitely an A1c to be proud of/ jealous about lol. It’s not easy getting ur A1c in the 4’s, no matter how healthy u are. And in fact, u dont want ur A1C too low. It can be indicative of having too many low blood sugar episodes, and low blood sugar can have very serious consequences. So in most people that aren’t on insulin for their diabetes, will not be able to get their A1C below a certain point, and that’s a good thing. If an A1C of say 4.8-5.2 means ur blood sugars were regularly between 70-100 over the course of the last 3 months, u don’t want to see ur A1C below this range, because u don’t really want to see ur blood sugar consistently lower than 70. So there’s just a threshold that u want to keep ur A1C above, and its actually unhealthy to see it go below that

manny816 said:

I will try and keep this short. I was diagnosed with low T back in 2023. After 3 years my clinic shut down and I decided to go UGL until this month. During those 7 years, my protocol was 200mg test C a week broken down to 2x weekly sub Q injections. No HCG and no AI. Since then I have been diagnosed with Bipolar / Manic Depression and put on antipsychotics and antidepressants. 2 months ago I lowered my dose to 150mg a week.
I have attached my recent bloodwork and as you can see my E2 is pretty high. Since then I have signed up with a new clinic and have been put on Test C 120mg a week to be broken down into 3 weekly injections. 500iu HCG 2 x a week and .25mg AI 2 x a week. I have also donated a power red at the Red Cross to try and bring down RBC and HCT.
Do you think that the high E2 can be the cause of the manic depressive diagnosis? I do have an appointment with my Physiatrist next week to discuss this. I also have a Uborligist appointment to review PSA results.

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For sure!