Recent content by arseniol

sorry, I missed it. my lab suggested testing bioavailable through RIA, does it make sense?

What do you mean by "Direct"? Do you mean from using total T, SHBG, and albumin with Vermeulen formula? Or do you mean RIA? RIA is another world, maybe it has some meaning, but would need a conversion.

late answer, these numbers are actually available in the patent WO2014138026A1 - Methods and systems for the diagnosis and treatment of androgen disorders - Google Patents

Are the "Multi-step Dynamic Binding Model with Complex Allostery" (also named FTz) and Tru-T really the same, or does Tru-T come with some new fixes?

Thanks again @Cataceous for this meaningful sponge analogy. I agree with @Funkodyssey this helps a lot to have a better picture of the whole mechanism. According to the literature I found, the half-life of SHBG-trapped T is longer, but not terribly much, which means that the sponge is actually...

for me, the main issue is that this algorithm is still a black box, which doesn't seem yet validated by the medical community. ppi'd also like to see if there are some tools to compute the Zakharov free t which seems to provide pretty reliable results.

then you trust more equilibrium dialysis than any computed FT?

Thanks for your explanation, makes a lot of sense. It would be interesting to have an index related to indigenous production. But due to this half-life point, it would be quite well following the free T value. as far as I've seen Zakharov and TruT are estimating a lower impact of SHBG than...

lolol Do you have a specific condition which makes the TruT and equilibrium dialysis so different?

Thanks so much, @Cataceous. This high SHBG is pretty sad, it destroys a nice indigenous production. Where may I find the ranges for Tru-T?

TrutT seems to give bad results with high SHBG, at least there are very far of what is obtained with RIA. my case: Total 685 ng/ml, shbg:67 nmol/L FTc(trut) -> 18.91 ng/dL FTc(Vermellen/issam.ch) -> 9.29 ng/dL FT(RIA) -> 11.0 pg/mL = 1100 pg/dL = 1.1 ng/dL