Testosterone (T) deficiency (TD; hypogonadism) has deleterious effects on men’s health; negatively affects glycometabolic and cardiometabolic functions, body composition, and bone mineral density; contributes to anemia and sexual dysfunction; and lowers quality of life. Testosterone replacement therapy (TRT) has been used for the past 8 decades to treat TD, with positive effects on signs and symptoms of TD.
A large body of evidence provides significant valuable information pertaining to the therapeutic value of TRT in men with TD. TTh in men with TD provides real health benefits for bone mineral density, anemia, sexual function, metabolic and cardiovacular function, and improvements in body composition, anthropometric parameters, and quality of life.
A review of studies attempted to determine the time-course of the effects induced by testosterone replacement therapy from their first manifestation until maximum effects are attained.
This review found that:
· Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond.
· Changes in erections/ejaculations may require up to 6 months.
· Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer.
· Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks.
· First effects on erythropoiesis (increased red blood cells) after 3 months, peaking at 9-12 months.
· Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy.
· Effects on lipids appear after 4 weeks, maximal after 6-12 months.
. Insulin sensitivity may improve within few days, but effects on glycemic control become evident only after 3-12 months.
· Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years.
. Effects on inflammation occur within 3 to 12 weeks.
· Effects on bone detectable after 6 months but continue at least for 3 years.
For information on how to prevent or reverse side effects of testosterone, click here:
The following graph shows how many weeks it may take for maximum results