Melatonin is also a big immune system booster.

Vince

Super Moderator
"The safety data on melatonin is astounding. So far no one has been able to find a toxic dose! Many of the leading researchers on melatonin in the world take more than 100 mg every day just to prevent cancer. I routinely start all my cancer patients on a minimum of 60 mg per day and use up to 200 mg per day. In addition, it can be taken throughout the day. So if you have cancer, talk to your doctor about adding melatonin to your treatment. It could save your life."

https://www.secondopinionnewsletter...an-melatonin-help-treat-bloodbased-tumors.htm
 
For men, I believe melatonin in high doses is one of many things that blocks the enzyme that creates DHT, so that is something to watch for symptoms of. Shift work is a known risk for cancer via the melatonin disruption, however I am less familiar with how well it works for advanced cancers.
 
If I take more than 3 mg at bed time I have a hangover for most of the next day. I could not imagine taking 60mg.
I just recently started taking 3 mg of Now brand of Melatonin, I dissolve it in my mouth when I go to bed. It has improved my sleep and no morning hangover. FeelingLost I'm sorry to hear that it doesn't help your sleep.
 
I just recently started taking 3 mg of Now brand of Melatonin, I dissolve it in my mouth when I go to bed. It has improved my sleep and no morning hangover. FeelingLost I'm sorry to hear that it doesn't help your sleep.

Oh sorry Vince I must have miss wrote that. 1-3mg works very well for me. Fogs my mind so I stop thinking and makes my legs numb so it is very easy to fall asleep.
BUT if I take more than 3 mg these effects last for half of the next day.

Although not as strong I prefer PURE's brand 5-HTP tryptophan 50mg. Some nights I will take two with no hangover then next day.
 
I was taking small doses of Melatonin like .25mg to .5mg nightly for approx 3 weeks and started suffering from very bad depression. Something I had never ever had before. I initially thought my E2 had crept up but I got that sorted and kept on with Melatonin and it hit me again the depression. So I googled it and in some case it's reported to be a problem. All this to say is I cut out melatonin 4 days ago and am felling much better. It's the only thing I added to my protocol in a number of years. So be aware that this can happen. It was stated that it messes with all your hormones... clearly some sort of imbalance occurred with me.
 
I went from 3mg to 0.5mg and it feels much better. There was a study (i think done by harvard) that showed that the ideal dosage for melatonin is around 0.3mg
 
It sounds like for sleep most do better with very low doses of melatonin. I didn't know they sold melatonin in microgram doses.
 
Hi Gene Devine

Thanks for highlighting this benefit!

Do you utilise it pre-workout as well? Do you follow the 5mg dose and any noticeable experience / results etc?
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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