Xyosted Prefilled Autoinjector for Subcutaneous Testosterone Administration

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HealthMan

Member
I received more of an explanation from my endo why he will not prescribe testosterone for sub q injection...he said the testosterone they use for IM injections is formatted differently than the used with sub q and xyosted injections? Is the testosterone for those who do sub q injections formatted differently than the testosterone for IM injections?
Thanks,
C
BS. Same thing. They put it in an auto injector so they can ask for a lot of money and pay a rebate for doctors that prescribe it. Sad. It probably cost them $10 dollars to produce and they sell for $500
 

Cataceous

Super Moderator
BS. Same thing. They put it in an auto injector so they can ask for a lot of money and pay a rebate for doctors that prescribe it. Sad. It probably cost them $10 dollars to produce and they sell for $500
On the other hand, those clinical trials probably cost them millions of dollars, and they helped all of us by proving that subQ is safe and effective. Now there's ammo for when doctors are insisting on IM delivery.
 

madman

Super Moderator
I received more of an explanation from my endo why he will not prescribe testosterone for sub q injection...he said the testosterone they use for IM injections is formatted differently than the used with sub q and xyosted injections? Is the testosterone for those who do sub q injections formatted differently than the testosterone for IM injections?
Thanks,
C



Hogwash!


Various testosterone esters used for trt (propionate, enanthate, cypionate, blend (propionate, phenylpropionate, isocaproate, decanoate), undecanoate

The most commonly prescribed esterified testosterone for trt is enanthate or cypionate.

Some also use propionate or a blend such as sustanon 250 (propionate, phenylpropionate, isocaproate, decanoate) or Nebido (undecanoate)

The only difference between the various testosterone esters is the ester side chain length/half-life

All forms of esterified testosterone can be injected intramuscularly (i.m) or subcutaneously (sub-q).....except Nebido (undecanoate) which would be injected intramuscular due to the large injection volume (1000mg/4ml)

Xyosted is just testosterone enanthate in an auto-injector designed to be used for subcutaneous injection which would be no different than one using testosterone enanthate drawn from a vial using a syringe and injected subcutaneously - the only main difference is using an auto injector to inject as oppose to a syringe.
 
I can’t inject myself so I think this is great for people that are in my situation. I am going to find out if my insurance comapny covers this otherwise I don’t think I would go on TRT. I certainly wouldn’t be able to afford it.
 

madman

Super Moderator
To be honest, I am very happy about the approval of this option. For the first time, doctors will be educated by pharma reps and CME classes about the fact that TRT can be prescribed as a subq injection. As insurance pre-authorization letters are becoming more prevalent, some doctors will opt to prescribe regular subcutaneous injections using insulin syringes.

This option starts a new conversation among doctors that take insurance.

Here is one of the first studies (pilot study) done at Royal Victoria Hospital, Montreal, Quebec, Canada, using the sub-q method with an insulin syringe.

The paper is from 2006.....study was done in 2002.

My urologist who manages my trt started a trial treating his patients using the sub-q method injected into abdominal fat shortly after it came out and has been doing so ever since.

In Canada, he is considered one of the pioneers regarding using sub-q injections for treating men on trt.




Subcutaneous administration of testosterone
A pilot study report


Objective

To investigate the effect of low doses of subcutaneous testosterone in hypogonadal men since the intramuscular route, which is the most widely used form of testosterone replacement therapy, is inconvenient to many patients.


Methods

All men with primary and secondary hypogonadism attending the reproductive endocrine clinic at Royal Victoria Hospital, Montreal, Quebec, Canada, were invited to participate in the study. Subjects were enrolled from January 2002 till December 2002. Patients were asked to self-administer weekly low doses of testosterone enanthate using a 0.5 ml insulin syringe.


Results

A total of 22 patients were enrolled in the study. ABSTRACT The mean trough was 14.48 ± 3.14 nmol/L and peak total testosterone was 21.65 ± 7.32 nmol/L. For the free testosterone, the average trough was 59.94±20.60 pmol/L and the peak was 85.17 ± 32.88 pmol/L. All of the patients delivered testosterone with ease and no local reactions were reported.


Conclusion

Therapy with weekly subcutaneous testosterone produced serum levels that were within the normal range in 100% of patients for both peak and trough levels. This is the first report, which demonstrated the efficacy of delivering weekly testosterone using this cheap, safe, and less painful subcutaneous route.




At the end of the paper, it is stated:


"In conclusion, this is the first report on the use of subcutaneous testosterone administration, which with new syringe technology appeared to be a safe, inexpensive, and effective form of treatment for hypogonadal men. Although the number of patients using subcutaneous testosterone was small, the overall clinical response was satisfactory. A large-scale study is needed to confirm these results. We foresee the production of a testosterone “pen” delivery system in the future"




Xyosted auto-injector FDA approved in 2019.....who knew?

LOL:D
 

Attachments

  • AUG10-SUB-Q-T-8.SaudiMedJ-2006 (2).pdf
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