Testosterone Replacement Does Not Cause Priaprism

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Nelson Vergel

Founder, ExcelMale.com
We have all watched TV advertisement for Viagra and Cialis in which they mention the risk of priaprism (prolonged erections for more than 1 hour). I really think that rare side effect is used to lead men to believe that they will have long acting erections when taking those ED drugs.

This study found not a single case of priaprism in men using a T gel.

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J Sex Med. 2013 Apr;10(4):1151-61. doi: 10.1111/jsm.12059. Epub 2013 Jan 24.
Testosterone replacement with 1% testosterone gel and priapism: no definite risk relationship.

Burnett AL, Kan-Dobrosky N, Miller MG.

James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287-2101, USA. [email protected]



Although testosterone replacement therapy (TRT) is the preferred treatment for hypogonadism, information for patients using testosterone includes too frequent or prolonged erections as a potential side effect.

To assess the frequency and risk of priapism or related adverse events (AEs) in hypogonadal men treated with a 1% testosterone gel.

Safety and tolerability data for AndroGel 1% were assessed, including three randomized, controlled clinical trials in varying populations of hypogonadal or near hypogonadal men. Study 1 was a Phase 3 trial of AndroGel 1% 5 g, 7.5 g, or 10 g once daily for 6 months (N = 227). Study 2 was a Phase 2 trial of AndroGel 1% 7.5 g once daily titrated as needed vs. placebo for 26 weeks in men with type 2 diabetes (N = 180). Study 3 was a Phase 4 trial of AndroGel 1% 5 g once daily vs. placebo for 12 weeks in men previously unresponsive to sildenafil 100 mg monotherapy and receiving concomitant sildenafil 100 mg (N = 75). Postmarketing AndroGel pharmacovigilance reporting data from 2001 to 2011 was searched for events coded as priapism.

The incidence of priapism and/or related symptoms reported as urogenital or reproductive system AEs.

In the 283 men exposed to AndroGel 1% over the three trials, mean exposure ranged from 84 days to 149 days. No AEs described as priapism or related symptoms were reported in the three trials. In the postmarketing data, representing 40 million units sold, eight cases described as priapism were reported. Of the six cases with accompanying data, all were judged as possibly related to AndroGel.

Safety data from the clinical trials for AndroGel 1% did not report any cases of priapism, and its incidence in the postmarketing pharmacovigilance data is extremely low, indicating a minimal risk of inducing priapism.
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