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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Recovery of sperm production following testosterone replacement or anabolic steroids
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<blockquote data-quote="Nelson Vergel" data-source="post: 36477" data-attributes="member: 3"><p><strong>History of Anabolic Androgenic Abuse Is Associated with Persistent Testicular Atrophy</strong></p><p></p><p><strong>Program:</strong> Abstracts - Orals, Poster Previews, and Posters</p><p><strong>Session:</strong> SUN 176-202-Male Reproductive Endocrinology and Male Reproductive Tract (posters)</p><p>Bench to Bedside</p><p></p><p><strong>Sunday, April 3, 2016: 1:15 PM-3:15 PM</strong></p><p>Exhibit/Poster Hall (BCEC)</p><p></p><p>Poster Board SUN 193</p><p><em><strong>Jon Bjarke Jarløv Rasmussen</strong></em></p><p></p><p><strong>Introduction:</strong> Abuse of anabolic androgenic steroids (AAS) causes a dramatic increase in plasma androgens and leads to testicular atrophy. The alterations are followed by hypogonadotropic hypogonadism due to a negative feedback mechanism of the hypothalamic-pituitary-testicular axis when abstinent from these substances. Whether AAS-induced hypogonadism and testicular atrophy are persistent is still unknown.</p><p></p><p><strong>Aim: </strong>To study the reversibility of AAS-induced testicular atrophy and AAS- induced hypogonadism.</p><p></p><p><strong>Methods and Results:</strong> Cross-sectional study among younger men (≤ 50 years): ongoing AAS abusers, n = 37; (age 31.4 ± 8.6 years, mean (SD)), former abusers, n = 25 (age 35.6 ± 6.9 years); median (IQR) abstinence duration from AAS of 2.1 (1.1 – 3.9) years and an age-matched control group who had never used AAS<strong>,</strong> n<strong> = </strong>26 (age 31.4 ± 6.8 years). Ongoing and former AAS abusers did not differ in terms of median (IQR) duration of AAS abuse, 140 (78 – 234) weeks during 5.0 (2.0 – 10.0) years vs.130(50 – 260) weeks during 8.2 (4.0 – 11.5) years, P=0.47.Blood samples were obtained between 08:00 to 09:00 AM. Plasma Total-Testosterone (p-TT), normal reference range: 10.3 – 27.4 nmol/L, were measured by mass spectrometry and plasma gonadotropins were measured by immunoassay. Testicular size was assessed using Prader’s orchidometer by one investigator (JR). The testicular size was markedly reduced among AAS abusers and former AAS abusers as compared with the control group 12 (10 – 12) mL vs. 15 (12 – 20) mL vs. 25 (20 – 25) mL, P<0.01. Further, testicular size was negatively correlated (Spearman’s rank correlation coefficient) with duration of AAS abuse among ongoing AAS abusers (r= -0.34, P=0.04), and former AAS abusers (r= -0.41, P=0.03). Ongoing AAS abusers had markedly supraphysiological levels of p-TT: geometric mean (95%CI) 75.6 (54.2 – 105.4) nmol/L, maximum value 592.1 nmol/L. Hypogonadism was not present among former AAS abusers as p-TT did not differ between controls and former AAS abusers: 18.4 (16.3 – 20.8)nmol/L vs. 14.8 (12.7 – 17.2) nmol/L, age-adjusted difference<strong>:</strong>P=0.43. Further, measurement of plasma free-Testosterone did not change this finding. Ongoing AAS abusers had clearly suppressed plasma gonadotropin levels, p-FSH: 0.3 (0.1 – 0-4) IU/L and p-LH: <0.3 IU/L, while median(IQR) plasma gonadotropin levels did not differ between controls and former AAS abusers, p-FSH: 4.2 (3.6 – 5.9) IU/Lvs. 4.1 (3.4 – 6.3) IU/L,P=0.87and p-LH: 3.2 (2.5 – 3.9) IU/L vs.3.5 (2.2 – 4.1),P=0.76.</p><p></p><p><strong>Conclusions:</strong> AAS-induced testicular atrophy may not be reversible even years after discontinuation of AAS abuse although we did not observe persistent hypogonadism in our cohort of former abusers of AAS. Testicular size is strongly associated with spermatogenesis and male fertility. Hence, it needs to be investigated further if former AAS abusers are in severe risk of irreversible impaired spermatogenesis and decreased fertility.</p><p></p><p>Nothing to Disclose: JBJR, CS, MS, FG, JF, CK</p><p><strong>*Please take note of The Endocrine Society's News Embargo Policy at<a href="https://www.endocrine.org/news-room/endo-annual-meeting/pr-resources-for-endo" target="_blank">PR Resources for ENDO | Endocrine Society</a></strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 36477, member: 3"] [B]History of Anabolic Androgenic Abuse Is Associated with Persistent Testicular Atrophy[/B] [B]Program:[/B] Abstracts - Orals, Poster Previews, and Posters [B]Session:[/B] SUN 176-202-Male Reproductive Endocrinology and Male Reproductive Tract (posters) Bench to Bedside [B]Sunday, April 3, 2016: 1:15 PM-3:15 PM[/B] Exhibit/Poster Hall (BCEC) Poster Board SUN 193 [I][B]Jon Bjarke Jarløv Rasmussen[/B][/I] [B]Introduction:[/B] Abuse of anabolic androgenic steroids (AAS) causes a dramatic increase in plasma androgens and leads to testicular atrophy. The alterations are followed by hypogonadotropic hypogonadism due to a negative feedback mechanism of the hypothalamic-pituitary-testicular axis when abstinent from these substances. Whether AAS-induced hypogonadism and testicular atrophy are persistent is still unknown. [B]Aim: [/B]To study the reversibility of AAS-induced testicular atrophy and AAS- induced hypogonadism. [B]Methods and Results:[/B] Cross-sectional study among younger men (≤ 50 years): ongoing AAS abusers, n = 37; (age 31.4 ± 8.6 years, mean (SD)), former abusers, n = 25 (age 35.6 ± 6.9 years); median (IQR) abstinence duration from AAS of 2.1 (1.1 – 3.9) years and an age-matched control group who had never used AAS[B],[/B] n[B] = [/B]26 (age 31.4 ± 6.8 years). Ongoing and former AAS abusers did not differ in terms of median (IQR) duration of AAS abuse, 140 (78 – 234) weeks during 5.0 (2.0 – 10.0) years vs.130(50 – 260) weeks during 8.2 (4.0 – 11.5) years, P=0.47.Blood samples were obtained between 08:00 to 09:00 AM. Plasma Total-Testosterone (p-TT), normal reference range: 10.3 – 27.4 nmol/L, were measured by mass spectrometry and plasma gonadotropins were measured by immunoassay. Testicular size was assessed using Prader’s orchidometer by one investigator (JR). The testicular size was markedly reduced among AAS abusers and former AAS abusers as compared with the control group 12 (10 – 12) mL vs. 15 (12 – 20) mL vs. 25 (20 – 25) mL, P<0.01. Further, testicular size was negatively correlated (Spearman’s rank correlation coefficient) with duration of AAS abuse among ongoing AAS abusers (r= -0.34, P=0.04), and former AAS abusers (r= -0.41, P=0.03). Ongoing AAS abusers had markedly supraphysiological levels of p-TT: geometric mean (95%CI) 75.6 (54.2 – 105.4) nmol/L, maximum value 592.1 nmol/L. Hypogonadism was not present among former AAS abusers as p-TT did not differ between controls and former AAS abusers: 18.4 (16.3 – 20.8)nmol/L vs. 14.8 (12.7 – 17.2) nmol/L, age-adjusted difference[B]:[/B]P=0.43. Further, measurement of plasma free-Testosterone did not change this finding. Ongoing AAS abusers had clearly suppressed plasma gonadotropin levels, p-FSH: 0.3 (0.1 – 0-4) IU/L and p-LH: <0.3 IU/L, while median(IQR) plasma gonadotropin levels did not differ between controls and former AAS abusers, p-FSH: 4.2 (3.6 – 5.9) IU/Lvs. 4.1 (3.4 – 6.3) IU/L,P=0.87and p-LH: 3.2 (2.5 – 3.9) IU/L vs.3.5 (2.2 – 4.1),P=0.76. [B]Conclusions:[/B] AAS-induced testicular atrophy may not be reversible even years after discontinuation of AAS abuse although we did not observe persistent hypogonadism in our cohort of former abusers of AAS. Testicular size is strongly associated with spermatogenesis and male fertility. Hence, it needs to be investigated further if former AAS abusers are in severe risk of irreversible impaired spermatogenesis and decreased fertility. Nothing to Disclose: JBJR, CS, MS, FG, JF, CK [B]*Please take note of The Endocrine Society's News Embargo Policy at[URL="https://www.endocrine.org/news-room/endo-annual-meeting/pr-resources-for-endo"]PR Resources for ENDO | Endocrine Society[/URL][/B] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Recovery of sperm production following testosterone replacement or anabolic steroids
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