Is Clomid (Clomiphene) Effective to Increase Testosterone and Sperm Volume?

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Nelson Vergel

I am trying to save many of you time in searching important information in key posts. Here is a list of good posts related to Clomid (clomiphene). This drug is used for fertility issues. Some doctors prescribe it to increase testosterone. Many patients report not feeling the same benefits with Clomid as they do with testosterone. A pharmaceutical company will seek approval of a clomid compound in a year as a treatment for low testosterone. It will be interesting how this will end up!!


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Nelson Vergel

More great information about testosterone replacement, HCG, testicular function, estradiol, anastrozole, exercise, nutrition and supplements:

Nelson Vergel

Predicting Biochemical Response to Clomiphene Citrate in Men with Hypogonadism.

AuthorsMazzola CR, et al. Show all Journal

J Sex Med. 2014 Jun 5. doi: 10.1111/jsm.12592.


INTRODUCTION: Clomiphene citrate (CC) is as an effective treatment for men with hypogonadism (HG). Identifying the ideal candidate for this strategy has to date largely relied upon a patient's interest in preservation of testicular volume and spermatogenesis.

AIM: This analysis was undertaken to define if predictors existed of robust elevation in serum testosterone (T) levels in response to CC.

METHODS: Seventy-six men with a diagnosis of HG (two separate early morning total T levels <300 ng/dL) opting for CC therapy constituted the study population. Demographic, comorbidity data, and physical and laboratory characteristics were recorded. Laboratory tests were conducted 4 weeks after commencement and every 6 months thereafter. Multivariable analysis was conducted to define if predictors of biochemical response could be identified. Parameters included in the model were patient age, mean testicular volume, varicocele presence, and baseline total T, free T, and luteinizing hormone (LH) levels.

MAIN OUTCOME MEASURE: Successful biochemical response to CC, defined as an increase of ≥200 ng/dL in total T level at ≥6 months after commencing CC, was the main outcome measure.

RESULTS: Mean age was 46 ± 22 years. Mean pretreatment testicular volume was 16 ± 8 mL. Mean baseline T and LH levels were 179 ± 72 ng/dL and 7.2 ± 5.6 IU/mL, respectively. Mean total T on CC was 467 ± 190 ng/dL. Forty-seven patients (62%) met the responder definition, with a mean increase in total T levels of 302 ± 76 (204-464) ng/dL. In CC responders, the mean LH rise was 5.6 ± 3.1 IU/mL. On multivariable analysis, factors predictive of CC response included: mean testicular volume (adjusted [adj.] r = 0.32, P < 0.01), mean testicular volume ≥14 mL (hazard ratio
2.2, P < 0.01), LH level (adj. r = 0.48, P < 0.001), and LH level ≤6 IU/mL (HR 3.5, P < 0.001).

CONCLUSION: These data indicate that two thirds of men with HG meet a robust responder definition and that pretreatment testicular volume and LH levels (in continuous and dichotomized fashions) are predictors of response.

Mazzola CR, Katz DJ, Loghmanieh N, Nelson CJ, and Mulhall JP. Predicting biochemical response to clomiphene citrate in men with hypogonadism.

Nelson Vergel

Here are some references for people to show their physicians who may need information about clomiphene.

Clomiphene studies are linked as follows:

1. Oral Enclomiphene Citrate Stimulates the Endogenous Production of Testosterone and Sperm Counts in Men with Low Testosterone: Comparison with Testosterone Gel

2. Clomiphene citrate is safe and effective for long-term management of hypogonadism.

3. Outcomes of clomiphene citrate treatment in young hypogonadal men

4. Clomiphene citrate and testosterone gel replacement therapy for male hypogonadism: efficacy and treatment cost.

5. Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit?

6. Hypogonadism, ADAM, and hormone replacement

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