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The Cystatin C Blood Test
The cystatin C blood test is used to monitor kidney function in people experiencing or suspected to have, kidney disease (1). If a physician suspects that you’re suffering from impaired kidney function they will likely order a cystatin C blood test.
The cystatin C test can be done instead of the creatinine or creatinine clearance test in cases where those tests aren’t appropriate (2), such as:
- In patients with cirrhosis
- Cases of morbid obesity
- Malnourishment
- Reduced or more than "normal" amount of muscle mass
- Patients taking creatine supplements that are increasing their creatinine and decreasing their estimated creatinine clearance (eGFR)
Since the concentration of cystatin C in the blood will not change due to infection or inflammation and isn’t affected by body weight, lean mass, drugs or diet - cystatin C level could be a more reliable indicator of kidney health than creatinine (2). On the other hand, creatinine has been shown to be affected by higher body weight and lean mass.
Testing for cystatin may also be useful to detect kidney disease early when the affected person isn’t experiencing many (if any) symptoms, and other test results are normal.
