ALP elevated, Lipitor?

[Nomad]

My ALP has been around 140 for the last two weeks. It was normal before Lipitor I started in February. My doctor is testing it because I want to go back on accutane.

Is this normal? My total cholesterol is <100 now. I had a 60% drop in LDL on 10mg of Lipitor daily.

EDIT: welp doctor called they can’t start accutane with elevated ALP levels…

 

[Systemlord]

EDIT: welp doctor called they can’t start accutane with elevated ALP levels…

WTF?

 

[Nomad]

WTF?

Yeah, my primary care doctor kind of got me freaking out earlier saying it could be cancer or even the testosterone injections. I’m going in tomorrow for a specific test which will determine where I’m my body the ALP is coming from.

From my research it’s odd that my ALT and AST isn’t elevated as well indicating it may not be my liver.

Last time I ran accutane (20mg daily) from a UGL my AST was the only value that raised and it went to 50 about 4 months in.

Edit: on 1/19 this year I had the minor heart attack and about 10 days later I was in the hospital with COVID.

 

[Nomad]

Here’s the recent results I started taking NAC 600mg twice daily between these last two tests.

 

[sammmy]

My ALP elevated from 40 to 75 U/L, while I was having a severe C. Difficile intestinal infection with diarrhea/colitis. The creatitine was also elevated from 0.95 to 1.22 mg/dL. The bacterial infection was notable on my CBC test as very elevated Neutrophils and Platelets.

 

[Nomad]

My ALP elevated from 40 to 75 U/L, while I was having a severe C. Difficile intestinal infection with diarrhea/colitis. The creatitine was also elevated from 0.95 to 1.22 mg/dL. The bacterial infection was notable on my CBC test as very elevated Neutrophils and Platelets.

What’s weird is I feel fine.

 

[sammmy]

I was just giving an example that ALP elevation may not be due to cancer or liver problem but a bacterial infection.

Which lab do you use that shows the same test over time? This is genius and allows to easily spot trends. I wish all labs did that.

 

[Nomad]

I was just giving an example that ALP elevation may not be due to cancer or liver problem but a bacterial infection.

Which lab do you use that shows the same test over time? This is genius and allows to easily spot trends. I wish all labs did that.

That’s my primary care/local hospitals webpage option, you can also view it as a line chart, I love it too!

EDIT. They out source a lot of their labs to quest diagnostics I just checked.

 

[sammmy]

So it's a lab data aggregating software. Quest plots line charts on their own patient portal but they are often not optimal to read - can't change the vertical axis. I'd rather have the number data.

What is the login page of your hospital if you don't mind?

I'll try to set up an account to see if it can pull and aggregate my Quest Diagnostics data. I'm tired of manually keeping track of it in Excel.

 

[Nomad]

So it's a lab data aggregating software. Quest plots line charts on their own patient portal but they are often not optimal to read - can't change the vertical axis. I'd rather have the number data.

What is the login page of your hospital if you don't mind?

I'll try to set up an account to see if it can pull and aggregate my Quest Diagnostics data. I'm tired of manually keeping track of it in Excel.

My.PeaceHealth.org

 

[Nomad]

Just a weekend update: will probably have more testing on Tuesday.

 

[sammmy]

It could be liver damage by Lipitor. The easiest way to check that is to stop Lipitor and retest.

How much is your total cholesterol without Lipitor? Dropping total cholesterol below 100 is a rather aggressive treatment, when controlling triglycerides probably matters more than dropping the cholesterol to the ground.

 

[Nomad]

It could be liver damage by Lipitor. The easiest way to check that is to stop Lipitor and retest.

How much is your total cholesterol without Lipitor? Dropping total cholesterol below 100 is a rather aggressive treatment, when controlling triglycerides probably matters more than dropping the cholesterol to the ground.

Attached is my most recent lipid panel.

The test results I shared earlier this afternoon signal it’s not a liver issue, but can be a bone or vitamin D deficiency thing which also points towards the Lipitor.

 

[sammmy]

Your Triglycerides are fine.

The test interpretation of high ALP and low normal GGT use the word "likely", so they do not rule out liver damage at 100%.

Statins are known to cause liver damage but typically more liver enzymes will be abnormal. What is strange is that you are on the lowest dose of Lipitor and yet your LDL is in the ground, showing an exaggerated response to it.