Anastrozole to Lose Stomach Fat?

Good Morning, Everyone

My name is Mark and I am new to this site. However; I have Klinefelter Syndrome. So I am on permanent HRT. I take Testosterone cypionate 400 mg every 10 days. It took convincing to get my Endocrinologist to increase the meds to 400 mg. Before that I was taking 200 mg and my results were terrible. I am now at: Testosterone 605 ng/dL 241 - 827 ng/dL. Which is good. However; my question that I am having and I am having a tough time finding the right doctor. Is my stomach fat. It is known by people with my condition to have stomach fat. I have been reading up on Arimidex. However; it is not as easy to convince someone who does not know your condition that well. Or how your body works to approve of taking Arimidex. I heard Arimidex is good for the stomach. I have a personal trainer who has helped built my body into a muscular dream for me. However; my stomach still remains after 2 years. Its frustrating. I have been on all types of diets. I have taking so many different types of supplements. However; I am continuously getting the same results. I am here today to ask someone if you know of another way. Of course I could simply pay out of pocket but it will get expansive. I do have good insurance. However; I am just stumped at this point in my life.

I found out that I have klinefelter when I was 38. Now I am 43. I am still growing taller. Yes it is true. Still going throw puberty when my doctor said its impossible.

Welcome to Exclemale. In order to focus the discussion, would you post all of the lab results you have (with the associated ranges)? You want to take anastrozole to lose stomach fat??? There is conversation on some of the steroid boards about this, but nothing here at EM - until now.

Anastrozole is a potent drug. Where does your estradiol sit? Was it measured with the sensitive lab test (LC, MS/MS)? If you live outside the US you may well be hard-pressed to find that test, but it is the appropriate test for men monitoring their estradiol. All of which is a prelude to my observation that what you propose, or what you are at least asking about, is a risky course of action. Estradiol levels can be thrown off kilter so very easily.

Welcome to ExcelMale, sounds like you're doing pretty good. Be careful with AI, I personally think the best way to get rid of belly fat is to go low carb. To get rid of fat, eat fat.

markwelbe1 said:

Good Morning, Everyone

My name is Mark and I am new to this site. However; I have Klinefelter Syndrome. So I am on permanent HRT. I take Testosterone cypionate 400 mg every 10 days. It took convincing to get my Endocrinologist to increase the meds to 400 mg. Before that I was taking 200 mg and my results were terrible. I am now at: Testosterone 605 ng/dL 241 - 827 ng/dL. Which is good. However; my question that I am having and I am having a tough time finding the right doctor. Is my stomach fat. It is known by people with my condition to have stomach fat. I have been reading up on Arimidex. However; it is not as easy to convince someone who does not know your condition that well. Or how your body works to approve of taking Arimidex. I heard Arimidex is good for the stomach. I have a personal trainer who has helped built my body into a muscular dream for me. However; my stomach still remains after 2 years. Its frustrating. I have been on all types of diets. I have taking so many different types of supplements. However; I am continuously getting the same results. I am here today to ask someone if you know of another way. Of course I could simply pay out of pocket but it will get expansive. I do have good insurance. However; I am just stumped at this point in my life.

I found out that I have klinefelter when I was 38. Now I am 43. I am still growing taller. Yes it is true. Still going throw puberty when my doctor said its impossible.

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Welcome.

Sounds like you're on a pretty odd protocol, 400mg E10D is certainly a high dose and a strange frequency.

I hope you have more labs than just a total testosterone level, as that is woefully insufficient for TRT follow up. Considering AI without an estradiol test, specifically the sensitive test, is a good way to chase your tail.

Do you have other tests? If you do, post them, it will only aid the discussion.

When was this test taken relative to injection?

The fact that you're growing taller suggests you do not have high E2, but klinefelter's patients usually have a higher E2 level than men without.

Having a 600 total even 10 days after a 400mg injection suggests a low SHBG level, as that is a large dose.

Vince said:

Welcome to ExcelMale, sounds like you're doing pretty good. Be careful with AI, I personally think the best way to get rid of belly fat is to go low carb. To get rid of fat, eat fat.

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I would say calories consumed vs calories burned is more critical than low carb/high fat as regardless of macro nutrient intake you can still accumulate body fat on a low carb/high fat diet if you are consuming too many calories.............be more specific when you throw around eating low carb is the best way to lose belly fat because many will also disagree!

Hello, CoastWatcher

I live in Alexandria Virginia. Unfortunately its hard to get an Estradiol test. However; I am working on finding a different doctor to assist me with taking one.

markwelbe1 said:

Hello, CoastWatcher

I live in Alexandria Virginia. Unfortunately its hard to get an Estradiol test. However; I am working on finding a different doctor to assist me with taking one.

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It's far easier than you think. Simply order it yourself through www.discountedlabs.com. The sensitive E2 test is what you want. It's a service many, many members here rely on.

markwelbe1 said:

Hello, CoastWatcher

I live in Alexandria Virginia. Unfortunately its hard to get an Estradiol test. However; I am working on finding a different doctor to assist me with taking one.

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Absolutely do not use AI until you have an estradiol test, and have other high E2 symptoms than just belly fat.

You can use discounted labs in VA to order your own if a doctor won't order them for you.

Test, free, sensitive E2 and SHBG would be a good start. It's best to have them done day of injection but before injection.

johndoesmith said:

Welcome.

Sounds like you're on a pretty odd protocol, 400mg E10D is certainly a high dose and a strange frequency.

I hope you have more labs than just a total testosterone level, as that is woefully insufficient for TRT follow up. Considering AI without an estradiol test, specifically the sensitive test, is a good way to chase your tail.

Do you have other tests? If you do, post them, it will only aid the discussion.

When was this test taken relative to injection?

The fact that you're growing taller suggests you do not have high E2, but klinefelter's patients usually have a higher E2 level than men without.

Having a 600 total even 10 days after a 400mg injection suggests a low SHBG level, as that is a large dose.

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Thanks for the reply.

I am going to find whatever test results that I can find. My estrogen I believe has always been high. Growing taller in my opinion is a good thing. I definitely want to try out the Anastrozole. I see that some are able to get this by online services. Which sites are safe to buy from?

Anastrozole

markwelbe1 said:

Hello, CoastWatcher

I live in Alexandria Virginia. Unfortunately its hard to get an Estradiol test. However; I am working on finding a different doctor to assist me with taking one.

Click to expand...

discountedlabs.com

July 1 2016 collected, July 2 2016 Resulted Testosterone: 170 ng/dL Standard Range: 241 - 827 ng/dL

Oct 20 2016 collected, Oct 21 2016 Resulted Testosterone: 605 ng/dL Standard Range: 241 - 827 ng/dL

markwelbe1 said:

Thanks for the reply.

I am going to find whatever test results that I can find. My estrogen I believe has always been high. Growing taller in my opinion is a good thing. I definitely want to try out the Anastrozole. I see that some are able to get this by online services. Which sites are safe to buy from?

Anastrozole

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Please don't do this without knowing where you stand in regard to your estradiol levels. You don't make androgen-related decisions in the absence of lab results. It is a ticket to misery if you push e2 below a healthy level. Don't go off in a reckless fashion.

CoastWatcher said:

Please don't do this without knowing where you stand in regard to your estradiol levels. You don't make androgen-related decisions in the absence of lab results. It is a ticket to misery if you push e2 below a healthy level. Don't go off in a reckless fashion.

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Do not worry not reckless. I am too old to be reckless. I have been very impatient. I will look into discounted labs and go from there. Thank you

madman said:

I would say calories consumed vs calories burned is more critical than low carb/high fat as regardless of macro nutrient intake you can still accumulate body fat on a low carb/high fat diet if you are consuming too many calories.............be more specific when you throw around eating low carb is the best way to lose belly fat because many will also disagree!

Click to expand...

You're very fortunate that you can be a carb eater. I did have a big tummy. To lose it, I had to stop eating.

I have KS too. I take .5cc T cyp every 3 days with .5mg of anastrozole and I feel great. I also take liquid cialis from toppeptides daily and feels like im 18 again. Before TRT, my level was 36. I used to be on higher doses of T cyp before, but it didn't work for some reason. Since taking the AI and a lower dose of T, everything seems to work out.

markwelbe1 said:

Do not worry not reckless. I am too old to be reckless. I have been very impatient. I will look into discounted labs and go from there. Thank you

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400MG/10DAYS and trying to tank your Estrogen with Anastrozole in some stomach fat pursuit, are wreckless.

If you research some on Nelson's posts. I believe there is an article/study that found e2 being to low actually stores fat at a greater rate than higher e2.


Try a clean diet.

Excuse me gentlemen I keep reading you all think you understand what I am going through. Now I came here to ask for answers. However; you guys keep throwing around the answer wreckless. I have klinefelter Syndrome. I have it for life and there are a lot things that I through daily. You have know idea. Well I know my body and I am going to do the test but do not think that you know me and what klinefelter is. Wow. It amazes me how you just think that you know me. I appreciate your confidence. I am 43 year old man who has been seeing all types of doctors. Some of you do not have what I have. I just came here for advice not to be looked like a fool. But thank you.

Thank you too those few who keep throwing around the words wreakless. You do not know me. I am not ten years of age.

Wow. I am will not reply back to this thread. I am done.

These are facts that we here know and is the general consensus of the board: Anastrozole is an aromatase inhibitor that is over prescribed, overdosed, and overused by men. These are facts. Every week a new guy or three comes here having tanked his Estrogen through overuse of Anastrozole. That's what can happen to you, reason some of us have questioned it as wreckless. Low E is very bad for men. You've not offered a single Estrogen test to tie to why you need Anastrozole. It's not a stomach fat reducer. I'm not unfamiliar with Klinefelters but perhaps you'd be better served on a forum more centrist to that issue.

Weasel said:

If you research some on Nelson's posts. I believe there is an article/study that found e2 being to low actually stores fat at a greater rate than higher e2.


Try a clean diet.

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Weaser is right.

STUDY LOOKING AT THE EFFECT OF ESTRADIOL ON FAT MASS, SEX DRIVE AND ERECTILE FUNCTION


There was a recently published groundbreaking study about the role of estradiol in men. No optimal ranges of estradiol were noted but low levels were associated with increase fat and decrease in sexual desire and erectile function compared to higher levels (the highest average estradiol was 35 pg/ml unfortunately, so no conclusions can be made for levels above this).

Men had their hormones blocked by a gonadotropin releasing hormone antagonist. All of them then received testosterone supplementation with Androgel. Half were also treated with anastrozole to block estradiol conversion from the testosterone. Please refer to attached graphs.

All participants (Cohorts 1 and 2) received goserelin acetate (Zoladex, AstraZeneca), at a dose of 3.6 mg subcutaneously at weeks 0, 4, 8, and 12, to suppress endogenous gonadal steroids (testosterone and estradiol). All participants (Cohort 1 and 2) were then randomly assigned to receive 0 g (placebo), 1.25 g, 2.5 g, 5 g, or 10 g of a topical 1% testosterone gel (AndroGel, Abbott Laboratories) daily for 16 weeks. Participants in cohort 2 also received anastrozole (Arimidex, AstraZeneca) at a dose of 1 mg daily to block the aromatization of testosterone to estrogen. Participants were unaware of the study group assignments.

Findings:

Higher blood levels of testosterone decreased the percentage of body fat (P = 0.001), intra abdominal fat area (P = 0.021), and subcutaneous fat area (P = 0.029), and increased sexual desire (P = 0.045) and erectile function (P = 0.032).

Low blood level of estradiol was associated with significant increases in the percentage of body fat (P<0.001), subcutaneous fat area (P<0.001), and intra abdominal fat area (P = 0.002), and relative less improvement in sexual desire (P<0.001) and erectile function (P = 0.022). These findings provide additional evidence of an independent effect of estradiol on these variables.

"Our finding that estrogens have a fundamental role in the regulation of body fat and sexual function, coupled with evidence from prior studies of the crucial role of estrogen in bone metabolism, indicates that estrogen deficiency is largely responsible for some of the key consequences of male hypogonadism and suggests that measuring estradiol might be helpful in assessing the risk of sexual dysfunction, bone loss, or fat accumulation in men with hypogonadism. For example, in men with serum testosterone levels of 200 to 400 ng per deciliter, sexual desire scores decreased by 13% if estradiol levels were 10 pg per milliliter or more and by 31% if estradiol levels were below 10 pg per milliliter. "
Reference:

Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men
N Engl J Med 2013;369:1011-22.