Side-by-side Estradiol Test Results

Vince Carter · Mar 23, 2016

I have these for your consumption where we talk about the differences between LC/MS/MS testing of Estradiol, I thought I'd share the following.

These are the same lab (Quest), same day, same draw, and look at the difference. Noteworthy is my sensitive test is HIGHER:

Estradiol 46 (< or = 39)
Estradiol Ultrasensitive LC/MS/MS 60 (< or = 29)

ERO · Mar 23, 2016

Very interesting! Weird though as 'conventional wisdom' states that the standard test typically overstates one's E2 levels instead of the other way around.

CoastWatcher · Mar 23, 2016

Vince Carter said:
I have these for your consumption where we talk about the differences between LC/MS/MS testing of Estradiol, I thought I'd share the following.

These are the same lab (Quest), same day, same draw, and look at the difference. Noteworthy is my sensitive test is HIGHER:

Estradiol 46 (< or = 39)
Estradiol Ultrasensitive LC/MS/MS 60 (< or = 29)

If it wasn't "same draw", I would have felt comfortable rationalizing it.

Gene Devine · Mar 23, 2016

The point is the standard default E2 lab is just inaccurate for measuring E2 in men and young children.

The Ultra Sensitive assay is much more accurate and the one you should rely on.

Yes, the default E2 lab tends to over estimate values...but not all the time...it's just not accurate for men and children.

Use the Ultra Sensitive as the correct assay.

HoustonTX · Mar 23, 2016

Interesting to see this post! I've had 2 blood draws several months apart and had the sensitive e2 test run from the same blood draw and both times the difference was statistically insignificant, within a couple of points. I've seen no difference between the tests personally. I'll post the lab results tonight or tomorrow. I realize that technically the sensitive test is more accurate. There's no arguing that. It's shown little value for me, though

Vince Carter · Mar 23, 2016

CoastWatcher said:
If it wasn't "same draw", I would have felt comfortable rationalizing it.

It wasn't by design, Defy wrote my script as "Sensitive Estradiol" but checking the Quest Tech's accuracy, I pointed out that she had entered the standard test, so she had to go back and in the process ordered BOTH tests. Made for an interesting comparison. Of course the Ultra is the more accurate test no matter the comparison to the standard test.

CoastWatcher · Mar 23, 2016

Vince Carter said:
It wasn't by design, Defy wrote my script as "Sensitive Estradiol" but checking the Quest Tech's accuracy, I pointed out that she had entered the standard test, so she had to go back and in the process ordered BOTH tests. Made for an interesting comparison. Of course the Ultra is the more accurate test no matter the comparison to the standard test.

Are you experiencing any estradiol-related symptoms? High/low...or nothing you're aware of.

Vince Carter · Mar 23, 2016

I have to admit to being irritable and easy to aggitate but I'm kind of a jerkoff anyway so I get them confused. Otherwise a little warm at night, not quite the night sweats.

Side-by-side Estradiol Test Results

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