Search results for query: Selegiline

...testosterone. Something else to look into is things that raise dopamine activity. There are various supplements you can try, as well as drugs such as selegiline. How do you respond to stimulants like caffeine? I'm wondering if you have any hints about what lessens your remaining symptoms.

Yes, I've been taking 2.5 mg/day consistently.

...I'm thinking of hormones that have natural pulsatile delivery, such as testosterone and GnRH. I don't have anything specific to add about selegiline. I wonder if the apparent half-life is reduced with sublingual delivery—and does this matter with a suicide inhibitor? That's a sharp memory to...

Optimistically, the selegiline and GnRH have so sharpened my memory that it just seems like you ask this all the time. I take 2.5 mg orally upon waking each day. This is on an empty stomach and without food. I've been on it since 2020.

...that correlated with the use of gonadorelin and enclomiphene. However, one possible confounding factor is that I had started taking selegiline in a similar time frame. I would tend to attribute more of the possible improvements to the GnRH, but for all I know there could be a synergistic...

...considering that many on TRT need less than 0.5 mg per week to adequately reduce prolactin. When I was taking it I maxed out at 31 mcg/day. Although my symptoms somewhat improved I was still not happy with the results. My current protocol includes selegiline, which might be doing something...

...a question of your tolerance and patience for further experimentation. There are various supplements to enhance neurotransmitters. I like selegiline in particular due to its other possible benefits. Being about your age I appreciate anything that can push back against the clock a little. You...

I'm still taking 2.5 mg/day. That's not necessarily micro-dosing.

...but I don't believe it can be sold except for research purposes. Peptide Sciences is among the more reputable US-based sellers of such peptides, which are also claimed to be US-made. On the dopamine-enhancing side I'm alluding to things like NALT, phenethylamine, selegiline, cabergoline, etc.

...experiment. If the issue is low dopaminergic activity then one could try the supplement N-acetyl-L-Tyrosine (NALT). Medications include selegiline and bupropion. Other supplements can be used to augment acetylcholine and excitatory neurotransmitters. How do you respond to caffeine? In theory...

With the caveats that N=1, much of the evaluation is subjective, and there are confounding variables: Yes, I did notice differences. Libido, sexual function and cognition all seemed to improve with gonadorelin. Confounding variables include use of selegiline and adjustments to testosterone dose.

I mentioned these metabolites in an earlier thread, suggesting that anyone subject to drug screening should avoid selegiline. Levoamphetamine is not that potent compared to dextroamphetamine, and is even "sold over-the-counter as a nasal decongestant."[R] You're free to characterize use of...

...this article a number of times. It might be on the optimistic side, but does give a decent overview of the potential benefits. Sample: "Selegiline (Deprenyl) provides selective protection against the age-related degeneration of the dopaminergic nervous system. It protects sensitive...

I view using selegiline as an attempt to counteract some of the effects of aging. I have said it's probably not something younger guys should be messing with. What swayed me was the description of the increase in MAO-B with aging, along with the promising animal studies. The main benefit I've...

Why not tackle it head on with a dopamine booster, e.g. selegiline?

I don't know more than what the Wiki article says: Pharmacokinetics Selegiline has an oral bioavailability of about 10%, which increases when ingested together with a fatty meal, as the molecule is fat soluble.[1][23] Selegiline and its metabolites bind extensively to plasma proteins (at a rate...

I use selegiline and think it helps, but it's just one piece of the puzzle. It's going to be more useful to those who would otherwise have relatively lower dopaminergic activity—sometimes reflected in rising prolactin.

...the article I linked to. I haven't stopped taking it for a long enough period to comment on withdrawal symptoms. My understanding is that selegiline works through suicide inhibition. This would imply there's not the kind of immediate rebound effect you might see with something like...

...using it for over two years now and consider it an integral part of my protocol. I'm not encouraging all and sundry to hop on it. I think selegiline is more appropriate for older guys—who are more likely to have rising MAO-B activity. But you will find recommendations for age-dependent doses...

...of the hypothalamus, leading to increased release of [dopamine], an excitatory neurotransmitter that increases sexual desire. I find selegiline and PT-141 to be quite dissimilar, even if both have some influence on dopaminergic activity. PT-141 did nothing for me but cause sleep-disrupting...

...First though: Have you measured prolactin? An elevated level can hurt libido. This problem can be attacked directly with cabergoline or selegiline. I found these treatments helped some, but did not deliver consistent results. As for more significant changes: One approach is to switch to a...

...for enhancing cognitive function in older people with mild cognitive impairment.” https://en.wikipedia.org/wiki/Phosphatidylserine Selegiline—“The monoamine oxidase-B inhibitor L-deprenyl (Selegiline) is effective in treating Parkinson’s disease and possibly Alzheimer’s disease. The...

...prolactin is closer to a desired target, such as 5-10 ng/mL. An alternative to cabergoline that might be better for overall health is selegiline. Selegiline directly raises dopamine, allowing you to start investigating the neurotransmitter angle of desire. You're a little on the young side to...

...There are stronger options available, including macuna pruriens and wild green oat extract. Pharmaceutical options include bupropion and selegiline. I would not recommend TRT, but a SERM as suggested by @bixt is a reasonable way to see if higher testosterone makes a difference. Another...

Yes, 2.5 mg/day, in line with the suggestion of low doses that are related to age. That's what I use. Judging by prolactin and mood it seems to be effective.

It's certainly moderate and not usually subject to abuse. But this reminds me that the drug can create amphetamine-related metabolites (levomethamphetamine and levoamphetamine). Wiki says that because of this it's possible to test positive on a drug screening test. So if you are subject to such...

This thread isn't complete without a mention of selegiline, aka L-deprenyl. It gives you higher dopamine and possible anti-aging effects. Quoting this article: Selegiline is a MAO-B inhibitor (in regular doses), it inhibits the enzyme monoamine oxidase type B that oxidizes dopamine, [and] as a...

...to prescribe cabergoline. Dr. Saya has mentioned prescribing with prolactin as low as 10 ng/dL when other problems are ruled out. A lesser-known alternative is selegiline. It may have some other benefits, which are described here. Since you're around 40 the anti-aging potential may be of...

...or medications. From another post: "On the mild side are L-tyrosine and NALT. More intense are things like wild green oat extract, macuna pruriens (L-Dopa), selegiline and cabergoline." A further step is to try increasing acetylcholine. Possible supplements include alpha-GPC and huperzine A.

...their store at any time. [LabCorp, Quest] Good prices there. I also had a baseline prolactin of 6 ng/dL. When it later crept over 10 I was getting close to anorgasmia. A different protocol and/or regular use of selegiline has solved the problem, with prolactin now a little under the old...

...would help regardless. On the mild side are L-tyrosine and NALT. More intense are things like wild green oat extract, macuna pruriens (L-Dopa), selegiline and cabergoline. You have to decide if you can accept the added complexity of counteracting the side effects of one drug by taking another.