Search results for query: SHBG clearance

What I don't understand is why you think verbatim repetition of something unsupported is not childish and a waste of bandwidth. Let's do baby steps then: Is testosterone restrictively metabolized or not? If not then please provide compelling evidence to contradict the references in my post on...

How sad that you cannot acknowledge basic logic: There's no evidence that above-range dosing is beneficial to overall health. There is evidence that above-range dosing is harmful to overall health. Dosing with 100 mg TC/week results in above-range levels in most men. Therefore do not start TRT...

Here are the things that caught my attention during a first pass through the article: SHBG-bound testosterone doesn't enter cells, doesn't activate androgen receptors, and doesn't produce the physiological effects you associate with having healthy testosterone levels. This issue is minor and...

Here is the reasoning: At steady state DHT is being cleared at the same rate it is being produced. If we can assume that clearance is proportional to the free hormone concentration then at steady state the free levels are always driven directly and proportionately by the production rate...

We should let others know that we have a spreadsheet posted for calculating free estradiol. Note that it is now attached to the post because the original links do not work: https://www.excelmale.com/forum/threads/spreadsheet-for-calculating-free-t-e2.17216/ The analogy of free/total estradiol...

If one is looking to maintain free testosterone at a particular level then it's typical to need dose reductions over time. This is because the metabolic clearance rate of testosterone tends to decrease with age, which in turn increases free testosterone, as mentioned here. It's harder to...

The reasoning is incorrect and contradicts what is set out in the original post. A drop in SHBG only transiently affects free testosterone. At the new steady state free testosterone returns to its previous value, which is tied only to the testosterone production/dose rate and the clearance rate...

I’ve covered this issue in many posts, but I thought it would be helpful to put more information in one thread and expand on the topic. TL;DR: Under TRT, free testosterone is proportional to the dose rate and inversely proportional to the metabolic clearance rate. The liver accounts for most of...

This highlights the confusion about whether total or free testosterone is the dependent variable. I've been arguing for years that total testosterone is the dependent variable, determined by free testosterone and the binding protein levels and other hormone levels. o The new data show that this...

I believe they are making this more complicated than necessary, and potentially reversing causes and effects. Under TRT the dose rate and metabolic clearance rate directly and proportionally determine free testosterone. In turn, total testosterone is driven primarily by free testosterone, SHBG...

We've been discussing this for years now. SHBG has little influence on free testosterone. The shift to lower SHBG under TRT does not change free testosterone at steady state. Free testosterone is determined by the dose rate and the metabolic clearance rate constant. The same applies when SHBG...

In fact this is usually the case. 100 mg per week in divided doses puts my total testosterone over 1,200 ng/dL, and this is common. @Readalot shared data supporting this proposition. Your low SHBG suppresses total testosterone. Free testosterone is proportional to the dose rate. By what method...

It also applies to TRT. Grok 3 again: Conclusion Given that testosterone metabolism follows first-order kinetics with respect to free testosterone, and at steady state the dose rate equals the elimination rate, the free testosterone level is indeed directly proportional to the dose rate. The...

Older men do get more "bang for the buck" from testosterone because the metabolic clearance rate declines with age. That is, free testosterone will typically go higher at the same dose as we age. There is no evidence that high levels of testosterone are healthier or to be preferred in any way...

It can be acknowledged that aside from suppressing the production of SHBG, mesterolone also ties up some fraction of the reduced level of SHBG, which leads to an even lower effective level. Conventional wisdom had held that this loss of SHBG leads to more free testosterone. However, it's...

If your free testosterone measurement is reasonably accurate then the implication is that the high androgen load has driven your SHBG to a low level. This in turn has reduced testosterone storage capacity, and thus total testosterone. Under these conditions total testosterone in isolation has...

In general there are some pretty good reasons to believe that average free testosterone should remain proportionate to the dose of testosterone. It is theoretically possible to have the underlying metabolic clearance rate constant shift, but it's questionable that this is common, given the...

Total testosterone has minimal relevance. Free testosterone is what you need to go by. If your SHBG is low then you can still have quite high free testosterone with the total at 559 ng/dL. That's why you should measure free testosterone and SHBG. Even if you have normal SHBG, you'd have to be...

At least three factors go into this: • SHBG. Free testosterone is probably proportional to dose, but total testosterone is also a function of SHBG. Low SHBG means lower total testosterone. • Absorption rate of the injected depot. There is still pretty significant variation in serum...

Consider it a strong hypothesis, almost to the point of being a theory. @readalot points to support in the mechanistic literature, e.g. here. I have also argued directly for it like this: The working hypothesis is that in steady state conditions free testosterone is directly proportional to...

The "k" is the constant you're trying to determine—it's related to your metabolic clearance rate for testosterone. When you multiply it by the dose rate you get an estimate for free testosterone: free_testosterone = constant * dose_rate The units for free testosterone and dose rate can be...

It seems like a reasonable hypothesis. Maybe, although the anecdotal evidence is rather indirect. Lower fluid retention has been reported with propionate versus longer esters. The assumption is that there's less estrogenic activity, but androgens also have a direct role in fluid balance. Ditto...

It looks like they are using Vermeulen calculated free testosterone, which is good. In spite of appearances, your testosterone has improved some, though it is lower than expected for the dose. Are you sure you were taking 80 mg every four days? What is the concentration of that testosterone...

I've come to prefer using ECLIA for testing estradiol due to its better reliability. However, this shouldn't be done unless you're pretty confident you won't see much cross-reactivity. If you can measure C-reactive protein and if it is low then you can probably trust an immunoassay estradiol...

@readalot previously pointed out that these results may be reflecting the inverse correlation of SHBG with body mass. If free testosterone can be viewed as fixed at a particular dose then lower SHBG implies lower total testosterone. The alternative is for body mass to be positively correlated...

For me it was the realization that conventional wisdom is incompatible with a couple very basic assumptions. Here's one of the posts where I lay out the reasoning. The working hypothesis is that in steady state conditions free testosterone is directly proportional to the production rate of...

Yes. The indirect evidence suggests my serum testosterone peaks with propionate and propionate blends are around three hours post-injection, which is when this measurement was made. According to Wikipedia, "The largest amounts of testosterone (>95%) are produced by the testes in men,[4] while...

With that level of total testosterone SHBG would more likely be on the high side. It's also common for the underlying metabolic clearance rate to decline with age, increasing serum testosterone levels relative to dose. It's odd you didn't get much of a honeymoon period, especially considering...

The working hypothesis is that in steady state conditions free testosterone is directly proportional to the production rate of endogenous testosterone, or to the dose rate of exogenous testosterone. Only two primary assumptions are necessary: 1) The rate of testosterone entering the system is...

Forcing down SHBG in isolation should not have much effect on free testosterone. Instead it drives down total testosterone. This does imply conventional wisdom has been incorrect. I've been guilty of promulgating such myself. It's good to keep an open mind and question beliefs that may not have...

As I was just arguing in another thread, it's part of the legacy of large and infrequent injections. There's greater focus on trough serum testosterone, so that's typically what drives the dose. But if you're injecting testosterone cypionate only once a week then its five-day half-life means...