madman
Super Moderator
Abstract
Purpose
According to many studies in the literature, there is a strong association between restless leg syndrome and dopaminergic dysfunction. Dopamine is also the major catecholamine in the retina and is also a possible transmitter of the amacrine and interplexiform cells. The aim of this study is to investigate the possible association between RLS and retinal thickness.
Methods
In this study, we included 33 patients who were diagnosed with idiopathic RLS according to the BInternational RLS Study Group^ criteria and 31 healthy subjects. All the patients and controls underwent routine ophthalmologic examination and had spectral-domain optical coherence tomography (OCT) performed. We compared the retinal thickness of the patients and control subjects.
Results
In the RLS group, foveal thickness was thinner then controls. Also, only inferior, superior, and temporal quadrant retina nerve fiber layer (RNFL) thickness were significantly thinner in the RLS group. The parafoveal ganglion cell complex (GCC) in the superior temporal, inferior temporal, inferior nasal quadrant, and perifoveal superior nasal thickness was also significantly thinner in the patient group. Pearson correlation analyses showed that there were statistically significant negative correlations between disease duration and macular GCC and RNFL thickness. Negative correlations were also detected between parafoveal superior, temporal, inferior and nasal macular thickness, parafoveal superior nasal, inferior temporal GCC thickness, and perifoveal superior nasal GCC thickness and disease duration.
Conclusion
According to our results; most retinal layers are thinner in RLS patients, so it can be considered that OCT has a predictive value for progression of RLS.
In conclusion; in the recent period the use of OCT to monitor progression and prognosis of neurodegenerative diseases like PD has become a focus. There has been limited research into the retinal changes in RLS, known to be related to dopamine metabolism. In our study, we showed the presence of some retinal changes in RLS patients and that these are correlated with the duration and severity of disease. Analysis of the macular thickness and retinal nerve fiber layer with OCT can be beneficial in follow-up of RLS progression.
Purpose
According to many studies in the literature, there is a strong association between restless leg syndrome and dopaminergic dysfunction. Dopamine is also the major catecholamine in the retina and is also a possible transmitter of the amacrine and interplexiform cells. The aim of this study is to investigate the possible association between RLS and retinal thickness.
Methods
In this study, we included 33 patients who were diagnosed with idiopathic RLS according to the BInternational RLS Study Group^ criteria and 31 healthy subjects. All the patients and controls underwent routine ophthalmologic examination and had spectral-domain optical coherence tomography (OCT) performed. We compared the retinal thickness of the patients and control subjects.
Results
In the RLS group, foveal thickness was thinner then controls. Also, only inferior, superior, and temporal quadrant retina nerve fiber layer (RNFL) thickness were significantly thinner in the RLS group. The parafoveal ganglion cell complex (GCC) in the superior temporal, inferior temporal, inferior nasal quadrant, and perifoveal superior nasal thickness was also significantly thinner in the patient group. Pearson correlation analyses showed that there were statistically significant negative correlations between disease duration and macular GCC and RNFL thickness. Negative correlations were also detected between parafoveal superior, temporal, inferior and nasal macular thickness, parafoveal superior nasal, inferior temporal GCC thickness, and perifoveal superior nasal GCC thickness and disease duration.
Conclusion
According to our results; most retinal layers are thinner in RLS patients, so it can be considered that OCT has a predictive value for progression of RLS.
In conclusion; in the recent period the use of OCT to monitor progression and prognosis of neurodegenerative diseases like PD has become a focus. There has been limited research into the retinal changes in RLS, known to be related to dopamine metabolism. In our study, we showed the presence of some retinal changes in RLS patients and that these are correlated with the duration and severity of disease. Analysis of the macular thickness and retinal nerve fiber layer with OCT can be beneficial in follow-up of RLS progression.
