Recent content by Cataceous

You had a nice honeymoon period on the initial weekly 80 mg TC dose and then crashed about the time that HPTA suppression took full hold. You've proved that more testosterone is not the answer, and you may be making things worse with the excess, crashing SHBG, feeling the need to manipulate...

We have debated this subject a lot. You have been dosed at a level that is likely on the order of double what your healthy natural production would be. It's no surprise that your numbers are off the charts. A lack of acute effects does not imply long-term safety in such levels. Hematocrit may...

Here are the things that caught my attention during a first pass through the article: SHBG-bound testosterone doesn't enter cells, doesn't activate androgen receptors, and doesn't produce the physiological effects you associate with having healthy testosterone levels. This issue is minor and...

You have offered very little to support this claim. You continue to point to the fact that taking 50 mg TC once per week yields poor results. This says nothing about how achieving physiological levels via divided doses of 50-75 mg per week compares to the above-physiological doses that you...

"Jumping to an absurd absolute." You mean like saying "And it is CLEARLY superior to 50 mg/week… no matter how you split the dosing." There is a significant cohort, myself included, that does much better on 50 mg TC per week split appropriately than at the excessive 100+ mg/week level you...

The cognitive dissonance lies with the one who acts like he can't distinguish between different dosing patterns for the same amount of testosterone in a given time period. By this way of thinking you can take your 5,200 mg of testosterone cypionate on January 1st and say you're done for the...

I wasn't even thinking about that aspect—the a priori artificial HPTA suppression—but that makes the comparison even worse. Nonetheless, a sustained protocol of 50 mg TC/week in one injection is still going to be highly suppressive, leading to hypogonadism later in each injection cycle. This is...

You rely on a straw man argument by making the comparison to a protocol that induces hypogonadism; after all this verbiage you still have not cited one study that directly compares our positions. You also don't respond to the assertion that your approach to TRT is out of line with science-based...

As if AI vomitus could save the day for you. The half-life of testosterone cypionate when injected intramuscularly is approximately eight days. Garbage-in, garbage out... That figure stems from old research that did not account for the interference of natural production.† Still waiting for...

Not one study saying that it is appropriate to start TRT with supraphysiological levels of testosterone. Many saying to start at mid-physiological levels. End of story.

These numbers are not estimates: they are a complete joke, and have no relationship to the real world,—except perhaps that 250 ng/dL as a trough for 50 mg TC/week. The peak for weekly TC injection is going to be two to three times the trough level. This falls out from the half-life alone and...

It's presumed that the lack of excipients gives Xyosted its relatively long have-life of 10 days. This is around double that of typical enanthate and cypionate formulations, and makes once-weekly injections feasible. I also like to call attention to the fact that the starting dose is 75 mg/week...

The big problem is that once-weekly dosing of 50 mg TC leaves most men hypogonadal later in each injection cycle—so the pattern is not remotely physiological. Obviously this causes problems. As a starting dose 50 mg must be divided, probably into at least EOD injections, even though some might...

Pair that with your low SHBG back then and you still had upper-range free testosterone, presumably at a trough. Peaks would then be over-range on the E3.5D protocol.

These parameters most likely can be improved sufficiently with the restoration of normal youthful levels. There's no evidence that going above what's physiological improves longevity. IGF-1 is a double-edged sword. It's useful, but also pro-aging. Maximum longevity is linked to levels that are...