Recent content by Cataceous

This is somewhat in line with previous case studies from Royal Medical Center, though this is the first time I've seen reporting on subjective results. RMC published good responses in LH and FSH to high doses of gonadorelin. However, I was assuming these were single pulses in response to each...

If a complete withdrawal seems too harsh then there's a chance you would get similar or better results with a switch to testosterone nasal gel for a period of time. HCG can still be pretty suppressive, which possibly limits the recovery of GnRH production, and maybe kisspeptin as well...

There are some nuances here. Systemic estradiol represents the sum of tissue-level aromatization. This hypothesis says that there can be local imbalances large enough to cause significant macroscopic effects, yet too small to noticeably affect serum estradiol. It's plausible, but I'd be...

The problem with the hypothesis is that testosterone esters such as cypionate are essentially inert, and you don't get pure testosterone until the testosterone ester interacts with enzymes that are predominantly in the bloodstream. This seems to rule out localized action, unless you're injecting...

My post is in the first of Nelson's links, but I'm going to highlight it so you don't miss it: If you are diagnosed with testicular insufficiency—primary hypogonadism—then be aware that it may be possible to dose your TRT in a way that minimizes the impact on other hormones. The technique...

At the core is the gonadorelin and the testosterone suspension (3 x 1.5 mg/day). There's also kisspeptin-10 and three other peptides. No hCG, but a little progesterone at bedtime. It's six injections a day, which is why I don't recommend it unless all else fails. At least the individual...

In this context they are referring to both high and low. The previous line is "While mid-cycle testing is convenient for patients, there may be value in assessing peak level (18-36 hours after injection) as the adverse events (e.g., polycythemia, hyperestrogenism) are likely at least partially...

You have yet to provide a single study that concludes that supraphysiological testosterone levels are superior to normal levels for overall health. I keep asking you to provide the quote but you can't. You're well aware that none of the studies you've cited says this. Back to the old straw man...

How sad that you cannot acknowledge basic logic: There's no evidence that above-range dosing is beneficial to overall health. There is evidence that above-range dosing is harmful to overall health. Dosing with 100 mg TC/week results in above-range levels in most men. Therefore do not start TRT...

Let's just cut to the bottom line, shall we? Query to Grok: Regarding men starting testosterone replacement therapy, is there any scientific evidence to support the claim that it is better for overall health when initial doses lead to serum testosterone levels that are often or constantly above...

Your choice of what to focus on says it all. You are willfully ignoring the bigger picture about which approach to dosing benefits the most men with the least harm. Instead of providing actual evidence that being out-of-range is better you'd rather we debate minutia over the interpretation of...

Nope, in context it is an example starting dose. Remember, they said the optimal dosing strategy has not been established. Therefore the actual recommendation is 50-200 mg every 1-2 weeks as needed to stay in the therapeutic range. From a practical standpoint, 100 mg would mean 90+% of men would...

From 2018. And even then the starting dose range was 50-200 mg every 1-2 weeks. By 2024 they were more clearly specifying the need to stay physiological.

No. I'm surprised you're still citing them. They want your TT to stay in the range of 450-600 ng/dL. The optimal dosing strategy has not been defined for short-acting IM testosterone preparations. Pharmacokinetics and Pharmacodynamics. The pharmacokinetics of short-acting testosterone therapy...

There's lots of verbiage here, but still no solid evidence supporting your hypothesis that TRT should be dosed to above-physiological levels rather than midrange, particularly at the start. No studies, no medical association recommendations, not even anecdotes. None of these is "right in front...