Recent content by Cataceous
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Test results for 8mg daily blend (Enan + Prop)
Here is the reasoning: At steady state DHT is being cleared at the same rate it is being produced. If we can assume that clearance is proportional to the free hormone concentration then at steady state the free levels are always driven directly and proportionately by the production rate...- Cataceous
- Post #28
- Forum: Testosterone Basics & Questions
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Test results for 8mg daily blend (Enan + Prop)
In steady-state conditions Proviron should not have much influence on free DHT unless it is significantly affecting 5ar activity. But I would expect a reduction, if anything, due to possible negative feedback of higher DHT-like activity. Otherwise Proviron is just adding on to existing DHT...- Cataceous
- Post #24
- Forum: Testosterone Basics & Questions
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TWICE PER WEEK TESTOSTERONE INJECTIONS ARE ASSOCIATED WITH GREATER RISK OF HIGH HEMATOCRIT
There's not going to be one fixed number. It depends on individual susceptibility. Also see the data tareload/readalot posted here, along with reasons why higher levels are problematic...- Cataceous
- Post #28
- Forum: Testosterone Side Effect Management
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Sex Hormone Binding Globulin (SHBG): The Complete Guide for Men on TRT
I have the usual quibbles: Low SHBG does not mean more free testosterone is available, on average. Free testosterone is determined by the production rate, or the dose rate when under TRT. The grain of truth in the statement is that the reduced buffering capacity of low SHBG means transients in...- Cataceous
- Post #6
- Forum: Testosterone Basics & Questions
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Pulmonary Oil Micro Embolism Research - Intro
Welcome, and thank you for your effort to increase our knowledge. In my ten years of frequenting the forums I have seen only a few reports of such symptoms. Perhaps this is due in part to the greater emphasis on taking divided doses. It's becoming less common to see men injecting 200 mg of...- Cataceous
- Post #2
- Forum: Introductions
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Less than 50 mg of T per week
Those are the gold-standard tests. Did you happen to have SHBG measured prior to TRT? If it used to be higher then it's another sign that this testosterone dosing is high for you, as androgens drive down SHBG. However, it's also possible that you are genetically predisposed to low SHBG. Such...- Cataceous
- Post #79
- Forum: Testosterone Basics & Questions
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How to decrease SHBG and increase free testosterone
What do your tests show? Lowering SHBG, either the actual levels, or virtually by tying it up with Proviron, does not affect free testosterone after stabilization, assuming an unchanged TRT dose. The original article should be updated to reflect this. It's covered in detail here...- Cataceous
- Post #4
- Forum: Testosterone Basics & Questions
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New Hair Loss Treatment Safer than Finasteride?: Clascoterone 5% Topical Solution
As I recall, the nightly dose was added to a PG-free Minoxidil Max product, while the morning dose was in ethyl alcohol and cyclomethicone.- Cataceous
- Post #12
- Forum: Testosterone Side Effect Management
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New Hair Loss Treatment Safer than Finasteride?: Clascoterone 5% Topical Solution
The dose was 1 mL. 50 mg/mL ~ 5% 25 mg/mL ~ 2.5%- Cataceous
- Post #10
- Forum: Testosterone Side Effect Management
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Less than 50 mg of T per week
Unless you have some other health issue this is suggesting that your dose is still too high for you. Although having total testosterone of 500 ng/dL may not seem excessive, with your daily injections you are probably maintaining this level 24 hours a day. This is an unnatural pattern, as...- Cataceous
- Post #73
- Forum: Testosterone Basics & Questions
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New Hair Loss Treatment Safer than Finasteride?: Clascoterone 5% Topical Solution
I tried clascoterone a few years back and could not tolerate it. At the time I noted a pounding heart and anxiety during two separate trials. The first trial was with 50 mg applied topically twice a day. The second was with half that dose, 25 mg. I asked the Grok AI if excess cortexolone could...- Cataceous
- Post #8
- Forum: Testosterone Side Effect Management
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TRT Review - Low SHBG, High E2, Crashing Libido
Any way you look at it the your dosing is excessive—basically double natural production. But regardless, before you head down other rabbit holes consider trying a more sensible initial strategy for treating primary hypogonadism, which I assume is what you have with one or both of the "boys"...- Cataceous
- Post #3
- Forum: Testosterone Basics & Questions
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Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
Here's the complete answer from the AI, for what it's worth: The claim that “your FSH-producing mRNA will decay” during an 8–12-hour overnight break from pulsatile gonadorelin injections is heavily overstated and essentially false in the context of real-world manual pulsatile gonadorelin...- Cataceous
- Post #90
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
@KNDyMan: Your contributions are welcome. A few comments: I am also skeptical of the weekly, high-dose gonadorelin protocols. I have not seen reports on what the subjective results are like. Royal Medical Center did demonstrate high levels of the gonadotropins shortly after the injections...- Cataceous
- Post #85
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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Lowering trt dose/ increasing frequency of injections question
I think 65 mg is a reasonable start. Be aware that dose reductions can trigger temporary symptoms of hypogonadism even when levels are adequate. Using proportionality does put total testosterone at weekly troughs in the mid 400s ng/dL with this protocol. As an aside, it is technically more...- Cataceous
- Post #30
- Forum: Testosterone Basics & Questions
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