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  1. C

    Advice needed. TRT started

    Why do you keep parroting this nonsense when there is high quality evidence that greater consumption of plant-based foods improves health? Carnivore is a very unbalanced diet, and one of the consequences is harm to the gut microbiome. ... it's important to know what determines a healthy gut...
  2. C

    First post. Can’t get E2 under control, starting to worry

    Methinks you need to run a sanity check on the numbers. The rat study is talking about millimolar concentrations (>100 mM/L). In contrast, serum testosterone is measured in nanomolar units. Isn't that on the order of a million times different?
  3. C

    Estradiol valerate experiment .

    Oral progesterone is decidedly unnatural. You get a large cascade of metabolites. Your premise doesn't hold for injections, but progesterone has a relatively short half-life, so you need to use it daily. Transdermal is probably ok too, but dosing is less precise and there are reports of unusual...
  4. C

    Issues with Empower Test-CYP?

    Something tells me there's more to those bills and expenses than food, clothing and shelter. You must forsake the rest if you really want to put people before money. If there's corruption as you allege then it is bred by the regulatory state. Libertarians might argue it's an inevitable result...
  5. C

    Advice needed. TRT started

    What are your priorities and tolerance for risk? If you value long-term good health above all then cut back to the initial dose, which is at least borderline physiological. There are risks in continuing with such high levels for years, but we can't be sure how significant they are. The data...
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    Issues with Empower Test-CYP?

    Sorry, you can't thread this needle. If these companies are greedy then so are you. You are undoubtedly making plenty more than needed to live. You could instead accept the minimum necessary and work free the rest of the time, thus prioritizing people over money. This is especially true with the...
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    Issues with Empower Test-CYP?

    You neglect to factor in all the government rules and regulations, which are the real reason for the big differences in price. UGLs do not need to worry about conforming to good manufacturing practices, etc. You might instead argue that big pharma doesn't mind the red tape too much because it...
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    Estradiol valerate experiment .

    I suggest waiting at least 1-2 months to see if there's movement in SHBG. The key thing is to get those androgens down and wait. Assuming you don't have a genetic predisposition to low SHBG, it probably took months to suppress yours to that degree, so expect the recovery to also take time. In...
  9. C

    Where to get Testosterone prescriptions?

    My suspicion is that this is yet another case of "start high, go higher", very common with injections. But maybe he's an exception. It's highly questionable that a guy needs more testosterone than any man on the planet could make naturally. But sure, if he's tried a range of physiological doses...
  10. C

    Daily Low Dose T cyp/prop results

    Given that the Vermeulen free T calculation isn't showing much change, I find it to be more credible. Is this Labcorp's ultrafiltration free T test? Although it's supposed to be an accurate method, if it's as temperamental as equilibrium dialysis then it's easy to envision an erroneous...
  11. C

    Where to get Testosterone prescriptions?

    Don't be so quick to dismiss the new doctor. It sounds like you're taking 180-200 mg of testosterone enanthate once a week, is this right? If so then you are taking about triple the testosterone the average healthy young guy makes naturally. This is not TRT. Feeling good in the short term is not...
  12. C

    Trt too high?

    @mchadcota: Your thread title is correct. I think @testiculus is offering the best advice, but consider dropping your testosterone dose into a physiologically realistic range over time. This is 50-100 mg of testosterone cypionate per week in divided doses. There's no evidence outside of a few...
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    My TRT Odyssey: Lab Results and More

    An issue with the cited paper is the use of an immunoassay to measure estradiol. No details are given about the assay, so there is some concern that measured estradiol could be artificially inflated in those men with elevated C-reactive protein. It seems likely that systemic inflammation alone...
  14. C

    you need to avoid seed oils (PUFA's)

    It's up to you to provide evidence linking these dietary studies to political taint. The fact that later controversial work invokes them is not evidence that the studies were themselves influenced. Why not do even a minute's research before making such pronouncements? Here's one of the separate...
  15. C

    you need to avoid seed oils (PUFA's)

    If you think that determining relationships in complex systems is as simple as taking a few measurements then we have nothing further to discuss.
  16. C

    you need to avoid seed oils (PUFA's)

    You're straying farther afield here; this is not the thread, or even the forum, for a debate on climate change. Let's stick to the studies on the health effects of plant- and animal-based foods. Now if you can provide evidence that the results of large studies and meta-analyses on this topic...
  17. C

    you need to avoid seed oils (PUFA's)

    You continue to make my case. I await your evidence of this vast conspiracy that favors increased consumption of plant-based foods. Are you going to defame the authors of the interventional studies too? These studies aren't as long-term but they still point to improved outcomes when plant-based...
  18. C

    AGE SPECIFIC CALCULATED FREE TESTOSTERONE RANGES IN ADULT MEN

    Yes. Here is one such study: https://journals.sagepub.com/doi/pdf/10.1258/000456306778520115
  19. C

    you need to avoid seed oils (PUFA's)

    For the nth time: The studies documenting favorable associations with greater consumption of plant-based foods are numerous and robust, and include longer time frames. The wordiness of your response does not strengthen a position that is basically anti-science.
  20. C

    Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene

    As mentioned later in this post on the previous page, Royal Medical Center is or was using such protocols. I haven't noticed patients of theirs making comments here, but it's possible there are reports elsewhere. It would be good to know if the relatively infrequent, but robust pulses of LH and...
  21. C

    you need to avoid seed oils (PUFA's)

    This summary of studies somewhat agrees, but you still won't like the conclusion: That said, replacing some of the saturated fat in your diet with unsaturated fat may offer several health benefits. This is not because saturated fat is “bad” but because unsaturated fats are particularly healthy...
  22. C

    you need to avoid seed oils (PUFA's)

    You should concentrate on what I said rather than raise straw man arguments about what I supposedly might think. You have not provided evidence that long-term high-meat diets provide benefits. You have also not cited studies showing that typical plant toxins in balanced diets are a health risk...
  23. C

    you need to avoid seed oils (PUFA's)

    This is terrible advice, unsupported by dozens to hundreds of studies, which instead associate a significant intake of plant-based foods with better health and longevity. Limited amounts of red meat can be a part of a healthy and balanced diet, but making it a main staple is a poor choice.
  24. C

    you need to avoid seed oils (PUFA's)

    We can to an extent, because obviously if I controlled a guy's calorie intake then I could make him lose an arbitrary amount of weight. Nonetheless, it can be exceedingly difficult to do this to yourself, particularly if you're used to eating processed foods. As you suggest, the concentrated...
  25. C

    AGE SPECIFIC CALCULATED FREE TESTOSTERONE RANGES IN ADULT MEN

    No, a cFTV (calculated free testosterone by Vermeulen) of 17.2 ng/dL is above average for healthy young men. Average for them is around 15 ng/dL. Or at least it was some decades back. As I said above: If you use the Vermeulen calculation then you can compare yourself to a range for healthy...
  26. C

    Estradiol valerate experiment .

    I suggest dividing the testosterone enanthate into at least 2-3 doses per week. With weekly doses, 50 mg is likely to send serum testosterone quite low at the end of each injection cycle. This and the transition from a very high dose would make for a pretty rocky road. An alternative is 50 mg TE...
  27. C

    AGE SPECIFIC CALCULATED FREE TESTOSTERONE RANGES IN ADULT MEN

    I wouldn't compare any free testosterone values to this study until it's clearer how they got their numbers. If you use the Vermeulen calculation then you can compare yourself to a range for healthy young men of about 70-230 pg/mL (7-23 ng/dL).
  28. C

    Weight Loss - Norepinephrine/Dopamine/TRT

    Mostly unproven claims based on anecdotes. The subject is beaten to death on the web. A good summary line: "Champion adds that there [are] 'no known long-term health benefits' of the carnivore diet, and supporters 'seem to ignore the mountains of quality research that has proven repeatedly that...
  29. C

    Trt-clomid-low shbg

    Many men do ok with 100 mg TE/TC per week, though it's still a fairly high dose. It was too much for me, and over the years I have lowered my dose to effectively less than 50 mg/week. Keep an open mind about further reductions in case you continue to have problems. HCG can contribute some...
  30. C

    you need to avoid seed oils (PUFA's)

    There are indeed foods that are clearly unhealthy, such as trans fats. Then there are foods such as the ones this thread is based on, where there's ambiguity and the current evidence is more in opposition to the proposition. As I argued in the previous post, it's largely a waste of time for the...
  31. C

    you need to avoid seed oils (PUFA's)

    Being a good weight is clearly orders of magnitude more important than the kind of in-the-weeds stuff you're promoting, especially since the observational studies point to health risks rather than benefits — with increasing red meat consumption — not just processed — or decreasing PUFA...
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