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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is TRT and What is NOT TRT
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<blockquote data-quote="xqfq" data-source="post: 208180" data-attributes="member: 38167"><p>While these studies provide an average, they have a very small sample size. While the metabolic clearance rate of this trideuterated testosterone molecule may pretty standard between men, isn't testosterone metabolized into inactive metabolites in different men at very different rates? Wouldn't these metabolites still have the trideuterated form and thus would would show up in these "traces" until they were cleared from the body?</p><p></p><p>I have read that:</p><p></p><p>"Approximately 50% of testosterone is metabolized via conjugation into testosterone glucuronide and to a lesser extent testosterone sulfate by glucuronosyltransferases and sulfotransferases, respectively" (<a href="https://en.wikipedia.org/wiki/Testosterone#Metabolism" target="_blank">Testosterone - Wikipedia</a>)</p><p></p><p>With respect to these metabolites, I found this study on doping which showed that some men with a certain gene have fairly different rates of metabolism of testosterone: <a href="https://pubmed.ncbi.nlm.nih.gov/18334593/" target="_blank">Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation - PubMed</a></p><p></p><p>[ATTACH=full]16448[/ATTACH]</p><p></p><p>I am not sure what to make of this yet. I think it is probably wrong to assume someone is e.g. supraphysiological based on dose of testosterone alone (which I don't see on this forum but do see on others).</p></blockquote><p></p>
[QUOTE="xqfq, post: 208180, member: 38167"] While these studies provide an average, they have a very small sample size. While the metabolic clearance rate of this trideuterated testosterone molecule may pretty standard between men, isn't testosterone metabolized into inactive metabolites in different men at very different rates? Wouldn't these metabolites still have the trideuterated form and thus would would show up in these "traces" until they were cleared from the body? I have read that: "Approximately 50% of testosterone is metabolized via conjugation into testosterone glucuronide and to a lesser extent testosterone sulfate by glucuronosyltransferases and sulfotransferases, respectively" ([URL='https://en.wikipedia.org/wiki/Testosterone#Metabolism']Testosterone - Wikipedia[/URL]) With respect to these metabolites, I found this study on doping which showed that some men with a certain gene have fairly different rates of metabolism of testosterone: [URL='https://pubmed.ncbi.nlm.nih.gov/18334593/']Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation - PubMed[/URL] [ATTACH type="full"]16448[/ATTACH] I am not sure what to make of this yet. I think it is probably wrong to assume someone is e.g. supraphysiological based on dose of testosterone alone (which I don't see on this forum but do see on others). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is TRT and What is NOT TRT
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