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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is TRT and What is NOT TRT
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<blockquote data-quote="Cataceous" data-source="post: 190809" data-attributes="member: 38109"><p>So people know what we're talking about I'll insert my <a href="https://www.excelmale.com/forum/threads/whos-currently-on-t-propionate.19925/post-167427" target="_blank">earlier criticism</a> of the MCR definition in this same study. I think it shows where SHBG fits in, and I also think SHBG is pretty independent of true MCR. I've noted before that with SHBG varying from low 40s nMol/L to low 20s, my free testosterone appeared to stay linear with dose.</p><p></p><p style="margin-left: 20px"><em>The issue with this study is that they are basing MCR on total T rather than free T. The standard equation used is:</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Production_rate = MCR * Hormone_concentration</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>But as I argued above, the proportionality applies to free testosterone, not total. So the equation should be:</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Production_rate = MCR * Hormone_concentration = MCR * FT = MCR * f(SHBG, T)</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>The reason it might appear to work anyway is because at constant SHBG, free T is nearly proportional to total T. So you get:</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Production_rate = MCR * f(SHBG, T) ~= MCR * f1(SHBG) * T = MCRx * T</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>The problem is that their measured clearance rate, MCRx, is actually dependent on both the underlying metabolism (MCR) and SHBG.</em></p><p></p><p></p><p>I think what you're seeing is the difference in true metabolism between the young and old groups. Free testosterone in the older guys is forced higher to overcome their slower metabolisms, because they still have to eliminate testosterone at the same rate as the younger guys—with all on the same fixed doses of testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 190809, member: 38109"] So people know what we're talking about I'll insert my [URL='https://www.excelmale.com/forum/threads/whos-currently-on-t-propionate.19925/post-167427']earlier criticism[/URL] of the MCR definition in this same study. I think it shows where SHBG fits in, and I also think SHBG is pretty independent of true MCR. I've noted before that with SHBG varying from low 40s nMol/L to low 20s, my free testosterone appeared to stay linear with dose. [INDENT][I]The issue with this study is that they are basing MCR on total T rather than free T. The standard equation used is:[/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]Production_rate = MCR * Hormone_concentration[/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]But as I argued above, the proportionality applies to free testosterone, not total. So the equation should be:[/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]Production_rate = MCR * Hormone_concentration = MCR * FT = MCR * f(SHBG, T)[/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]The reason it might appear to work anyway is because at constant SHBG, free T is nearly proportional to total T. So you get:[/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]Production_rate = MCR * f(SHBG, T) ~= MCR * f1(SHBG) * T = MCRx * T[/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]The problem is that their measured clearance rate, MCRx, is actually dependent on both the underlying metabolism (MCR) and SHBG.[/I][/INDENT] I think what you're seeing is the difference in true metabolism between the young and old groups. Free testosterone in the older guys is forced higher to overcome their slower metabolisms, because they still have to eliminate testosterone at the same rate as the younger guys—with all on the same fixed doses of testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is TRT and What is NOT TRT
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