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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is TRT and What is NOT TRT
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<blockquote data-quote="Cataceous" data-source="post: 190786" data-attributes="member: 38109"><p>As far as I can tell the study is at least not inconsistent with the points I've been arguing. For starters, the law-of-mass-action proportionality requires a linear relationship between dose and free T. We get that:</p><p>[ATTACH=full]11634[/ATTACH]</p><p>[ATTACH=full]11635[/ATTACH]</p><p>We know that the absolute metabolic clearances of subjects taking the same doses must be the same, high SHBG or low, young or old. At steady state, if you're taking in X mg per week of testosterone, then that's how much you're getting rid of each week. Call Dk some constant that's proportional to dose. Then:</p><p></p><p>MCR(young) * fT(young) = Dk = MCR(old) * fT(old)</p><p></p><p>or:</p><p></p><p>MCR(young) / MCR(old) = fT(old) / fT(young)</p><p></p><p>Taking the values from the graphs we get: MCR(young) / MCR(old) = 1.6</p><p></p><p>The young guys do have much higher metabolic rate constants.</p><p></p><p>What would be really nice to see is a non-linearity in total T with dose. Unfortunately it doesn't appear possible to illustrate with this dataset. Even among the young guys, the resulting SHBG values are too tightly grouped to show a divergence from the free T behavior. We would need an experiment in which there's a large difference in SHBG values.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 190786, member: 38109"] As far as I can tell the study is at least not inconsistent with the points I've been arguing. For starters, the law-of-mass-action proportionality requires a linear relationship between dose and free T. We get that: [ATTACH type="full" alt="Image 11-12-20 at 1.07 PM.jpg"]11634[/ATTACH] [ATTACH type="full" alt="Image 11-12-20 at 1.08 PM.jpg"]11635[/ATTACH] We know that the absolute metabolic clearances of subjects taking the same doses must be the same, high SHBG or low, young or old. At steady state, if you're taking in X mg per week of testosterone, then that's how much you're getting rid of each week. Call Dk some constant that's proportional to dose. Then: MCR(young) * fT(young) = Dk = MCR(old) * fT(old) or: MCR(young) / MCR(old) = fT(old) / fT(young) Taking the values from the graphs we get: MCR(young) / MCR(old) = 1.6 The young guys do have much higher metabolic rate constants. What would be really nice to see is a non-linearity in total T with dose. Unfortunately it doesn't appear possible to illustrate with this dataset. Even among the young guys, the resulting SHBG values are too tightly grouped to show a divergence from the free T behavior. We would need an experiment in which there's a large difference in SHBG values. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is TRT and What is NOT TRT
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