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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is TRT and What is NOT TRT
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<blockquote data-quote="Cataceous" data-source="post: 190760" data-attributes="member: 38109"><p>I like your rephrasing <a href="https://forums.t-nation.com/t/what-is-trt-and-what-is-not-trt/269828/166" target="_blank">over at T-Nation</a>: "<em>If you raise this ([lowest effective dose]) past physiological levels, which cover the very vast vast majority of the human population (non-outliers, not clinically diseased), we do not know what may occur (especially long-term) as there is scant evidence either way of what the outcome might be for you."</em></p><p></p><p>There's a fresh reminder in research [USER=13851]@madman[/USER] <a href="https://www.excelmale.com/forum/threads/a-paradoxical-decline-in-semen-parameters-in-men-treated-with-clomiphene-citrate-clomid.22076/post-189750" target="_blank">recently posted</a>. Sky's the limit on estradiol? Maybe not.</p><p style="margin-left: 20px"><strong><em>A paradoxical decline in semen parameters in men treated with clomiphene citrate</em></strong></p> <p style="margin-left: 20px"><strong><em>...</em></strong></p> <p style="margin-left: 20px"><em>Elevated estradiol levels result in vacuolization and increased glycoprotein production impairing Sertoli cell function. It also disturbs communication with germ cells, increases collagen synthesis and fatty degeneration in the testicular connective tissue. All these actions collectively result in the induction of germ cell death (Leavy et al., 2017). Oestradiol also plays a critical role in round spermatid chromatin reorganization during spermiogenesis through its action on Estrogen Receptor Alpha (ERα) present on Sertoli cells (Cacciola et al., 2013). Overexposure to estrogens reduces the expression of ERα on Sertoli cells, impacting this critical action. Moreover, it has been recognized that supraphysiological concentrations of estrogen act as powerful apoptotic triggers that induce germ cell apoptosis (Correia et al., 2015).</em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 190760, member: 38109"] I like your rephrasing [URL='https://forums.t-nation.com/t/what-is-trt-and-what-is-not-trt/269828/166']over at T-Nation[/URL]: "[I]If you raise this ([lowest effective dose]) past physiological levels, which cover the very vast vast majority of the human population (non-outliers, not clinically diseased), we do not know what may occur (especially long-term) as there is scant evidence either way of what the outcome might be for you."[/I] There's a fresh reminder in research [USER=13851]@madman[/USER] [URL='https://www.excelmale.com/forum/threads/a-paradoxical-decline-in-semen-parameters-in-men-treated-with-clomiphene-citrate-clomid.22076/post-189750']recently posted[/URL]. Sky's the limit on estradiol? Maybe not. [INDENT][B][I]A paradoxical decline in semen parameters in men treated with clomiphene citrate[/I][/B][/INDENT] [INDENT][B][I]...[/I][/B][/INDENT] [INDENT][I]Elevated estradiol levels result in vacuolization and increased glycoprotein production impairing Sertoli cell function. It also disturbs communication with germ cells, increases collagen synthesis and fatty degeneration in the testicular connective tissue. All these actions collectively result in the induction of germ cell death (Leavy et al., 2017). Oestradiol also plays a critical role in round spermatid chromatin reorganization during spermiogenesis through its action on Estrogen Receptor Alpha (ERα) present on Sertoli cells (Cacciola et al., 2013). Overexposure to estrogens reduces the expression of ERα on Sertoli cells, impacting this critical action. Moreover, it has been recognized that supraphysiological concentrations of estrogen act as powerful apoptotic triggers that induce germ cell apoptosis (Correia et al., 2015).[/I][/INDENT] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is TRT and What is NOT TRT
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