Variance in Peak and Trough T Levels in Men Using Intramuscular T Injections

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madman

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MP85-14 VARIANCE IN PEAK AND TROUGH TESTOSTERONE LEVELS IN MEN USING INTRAMUSCULAR TESTOSTERONE
Bruno Nascimento*, Helen L Bernie, Elizabeth Schofield, John P. Mulhall, New York, NY


INTRODUCTION AND OBJECTIVES

In men using intramuscular testosterone (IM T), clinical experience shows us that, despite stable dosing and frequency, total testosterone peak (Tp) and trough (Tt) levels are highly variable, thus challenging the clinician to make a decision regarding dose adjustments. The goal of this study was to define the variability in T levels in a population of men on IM T.

METHODS

Patients with 3 consecutive Tp and Tt levels available, while on a stable dose and interval of IM T cypionate were analyzed. All patients were instructed as follows: Tp levels to be checked 18 hours after IM T injection, and Tt levels to be drawn the following week on the day of injection, prior to injecting the next dose. We report on Tp, Tt, and D (Tp-Tt). T level was measured using LC/MS-MS. To assess for T level variation across the 3 cycles, we calculated mean change in Tp and Tt as well as maximal change in Tp and Tt. Distribution analysis was performed to assess for variance distribution.

RESULTS

29 patients met the inclusion criteria equating to 174 total T levels analyzed. The mean age was 52 ± 28y. Dose distribution was: 3% receiving 40mg, 10% 60mg, 35% 80mg, 38% 100mg, 7% 120mg, and 7% receiving other doses. 83% were injecting every 7 days. Averaged over 3 cycles, mean Tp was 910 ± 165 ng/dl; mean Tt was 558 ± 80 ng/dl, and mean D was 352 ± 154. Mean Tp variance was 210 ± 99 ng/dl representing a 23% change from cycle to cycle. Mean Tt variance = 102 ± 63 ng/dl (17.5% change). Averaged over all patients, maximum Tp change was 315 ± 148 ng/dl, and maximum Tt change was 152 ± 94 ng/dl, representing a maximum change of 37% and 26% respectively. In distribution analysis, 25% of patients had a maximum Tp change greater than 51% and a maximum Tt change of 35%.

testosterone injections variability.jpg



CONCLUSIONS

In our population of patients on stable IM T dose, there was a wide mean variation in both Tp (23%) and Tt (17.5%). In addition to that, 25% of patients had a maximum Tp change greater than 50% and a maximum Tt change greater than 35%. Clinicians should be aware of this high variability in levels when deciding on dose adjustment.

Source of Funding: None
 

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Defy Medical TRT clinic doctor

Nelson Vergel

Founder, ExcelMale.com
Very important point. The same can happen with testosterone gels/creams. Can you check the abstract source again since the numbers seem kind of weird to me? Thanks for posting!
 
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