Thoughts on GHK-cu capsules?

[NuSciencePeptides]

Will possibly be making these and was looking for feedback. I know several companies produce them and thought it may be a good addition. Also going to be adding BPC157 500mcg capsules as well in Jan.

 

[BadassBlues]

Will possibly be making these and was looking for feedback. I know several companies produce them and thought it may be a good addition. Also going to be adding BPC157 500mcg capsules as well in Jan.

It would definitely have to be in an enteric coated capsule. Peptides can't tolerate stomach acid.

 

[BadassBlues]

There have been studies done on the intestinal absorption of small peptides. It appears that they are easily absorbed, and that absorption can be enhanced by dietary factors.

https://ifst.onlinelibrary.wiley.com/doi/full/10.1111/ijfs.14048

Summary​

Peptides display diverse structural features because of their varied amino acid compositions. The structural diversity often imparts them complex physiological functions, or possible health-beneficial effects. Some small peptides (di-/tripeptides) exert preventive effects against conditions such as hypertension, hypercholesterolaemia and atherosclerosis. Despite their health benefits, a limited understanding of peptide absorption may hinder their extensive application. Therefore, this review briefly introduces the in vitro and in vivo findings on the intestinal absorption of small peptides and potential factors affecting their absorption.

Factors affecting the absorption of small peptides​

Current studies on the absorption of peptides are mainly conducted by a single oral administration of target peptides. However, as a food material, it is possible that co-existing compounds present in a food matrix could affect the absorption of peptides. For instance, although PepT1 exhibits a certain level of transport capacity and dose dependency (Jappar et al., 2011), the absorption of targeted small peptides could be competitively restricted when co-existing compounds share the same PepT1 transport pathway. In previous studies, we demonstrated that the transport of dipeptides Val-Tyr (Hong et al., 2013) and Trp-His (Tanaka et al., 2015) was inhibited by the existence of a PepT1 substrate Gly-Sar, using an ex vivo chamber transport experiment. Also, the blood concentration of a PepT1-transported dipeptidyl drug, captopril significantly decreased when administered simultaneously with a dipeptide Val-Tyr (Matsui et al., 2006). In such cases, the transport of dipeptide(s) mainly depends on the affinity (Km) to PepT1. On the contrary, some food compounds could alter the absorption of dipeptides by adjusting the expression of PepT1. It has been reported that dietary amino acids and protein (hydrolysates) could up-regulate the expression of intestinal PepT1 mRNA to increase the intestinal transporter capacity of PepT1 and facilitate the absorption of peptides (Shiraga et al., 1999; Osmanyan et al., 2018). Meanwhile, theaflavins, polymeric catechins, have been reported to down-regulate the expression of PepT1 via the activation of intracellular AMP-dependent kinase, thus restricting the transport of dipeptides (Takeda et al., 2013). In addition, Wenzel et al. (2001) examined thirty-three food derived flavonoids and reported that quercetin, genistein, naringin, diosmin, acacetin and chrysin had the potential to increase the absorption of PepT1-transported compounds by activation of apical Na+/H+-exchanger to maintain the proton gradient which serves as a driving force for PepT1-mediated transport. Similarly, because a proton is released when a non-charged fatty acid enters the cytosol, dietary fatty acids could also facilitate the absorption of dipeptides by maintaining the transmembrane proton flux (Spanier et al., 2009; Fig. 3). With regards to other macronutrients, carbohydrates have been reported to stimulate intestinal tissue anabolism, thus incorporating more peptides into the intestinal cells than released into blood circulation. In contrast, addition of fibre increased the systemic availability of di-/tripeptides (Ten Have et al., 2015). However, information is still limited on the effects of respective macronutrients on the absorption of small peptides.

[IMG alt="Details are in the caption following the image"]https://ifst.onlinelibrary.wiley.com/cms/asset/28628ce8-492e-4ee1-8723-9c834c9c2286/ijfs14048-fig-0003-m.png[/IMG]
Figure 3
Open in figure viewerPowerPoint
Factors affecting the absorption of small peptides. Food and non-food factors could affect the absorption of small peptides potentially via (1) competitive inhibition of PepT1, (2) transcriptional regulation of PepT1 and (3) maintenance of the proton gradient (a driving force for PepT1-mediated transport).
Besides food factors, the absorption of small peptides could also be affected by other factors such as health of the individual. In a recent study, we reported enhanced absorption of dipeptides Gly-Sar and Trp-His in 40-week-old spontaneously hypertensive rats (SHRs) and compared them to 8-week young SHRs. We discovered that the expression of intestinal PepT1 was significantly (~1.5-fold) higher in the 40-week SHRs, which could indicate its enhanced absorption (Hanh et al., 2017; Fig. 3). Although the mechanisms underlying the elevated expression of PepT1 are still not clear, we speculated that chronic inflammation and hypertension in ageing individuals could be involved in the regulation of intestinal PepT1 (Ingersoll et al., 2012).

 

[BadassBlues]

You mentioned that you are also working on an oral BPC-157 product. Here is an interesting read:

Oral BPC-157: Top Benefits and Effects Compared to Injecting

Discover the benefits of oral BPC-157. Learn how it compares to injections, its profound effects, and why it's a total game changer.

sarms.io

Oral BPC-157: Unveiling Its Potential Benefits for Your Health​

Oral BPC-157, a peptide gaining popularity for its potential health benefits, is what we’re diving into today. You’ve likely heard whispers of it in the fitness community or seen it making rounds on wellness blogs. But what exactly is this compound, and how can it help you?

BPC-157, also known as body protection compound 157, isn’t just another fad – there’s science to back up its efficacy. From accelerating wound healing to easing digestive disorders and even combating depression, BPC-157 appears to be a promising all-around therapeutic agent.

In this article, we’ll unpack everything you need to know about oral BPC-157: how it works, its potential health benefits, and the research behind these claims. By the end of your read through our comprehensive guide on BPC-157, you’ll have a clear understanding if this peptide should make an appearance in your health regimen.

The Scientific Background of BPC-157

Background​

Dive into the world of BPC-157, a synthetic peptide with an intriguing scientific backstory. You might be wondering, “What’s a peptide?” It’s a short chain of amino acids, the building blocks that make up proteins in your body.

Now, let’s talk about BPC-157 specifically. Its full name is Body Protection Compound 157, indicating its potential protective effects. This particular peptide has been extensively studied in animal models for its regenerative and healing properties.

Interestingly enough, BPC-157 is derived from a protein found in stomach juice. Yes! Your very own gastric juice contains something similar to this powerful compound.

The magic lies in its ability to accelerate wound healing and tissue repair. Whether it’s muscle injuries or skin wounds – preliminary studies suggest BPC-157 can speed up the recovery process significantly.

Here are some key findings:

• In rat models, oral administration of BPC-157 showed remarkable improvement in tendon-to-bone healing.
• Another study observed accelerated recovery from muscle tears.
• Some research even suggests potential benefits for gastrointestinal health due to its origin from gastric proteins.

Study Focus	Animal Model	Outcome
Tendon-to-Bone Healing	Rats	Improvement
Muscle Tear Recovery	Rats	Acceleration
Gastrointestinal Health Benefits	Various Animals	Potential

Remember though; these results are primarily based on animal studies. Human trials are still limited but ongoing – so we’re yet to understand fully how effective and safe oral BPC-157 is for humans over the long term.

In summary: BPC-157 may seem like just another string of letters and numbers right now. But delve deeper into it and you’ll find fascinating science backed by promising research that could potentially enhance your body’s natural healing abilities!

BPC-157’s Mechanism of Action Explained in Simple Terms

Mechanism of Action​

BPC 157 is often praised for its potential healing properties. But how does it work exactly? Let’s delve into its mechanism of action.

Firstly, you’ll want to understand that BPC-157 is what we call a ‘stable gastric pentadecapeptide’. This means it’s composed of 15 amino acids and is derived from a part of our body – specifically, the gastric juice in your stomach. Now let’s get into the nitty-gritty.

One key way BPC-157 operates is by accelerating wound healing. It achieves this by boosting angiogenesis – the formation of new blood vessels from pre-existing ones. Your body naturally uses angiogenesis to heal injuries but with BPC-157, this process gets an extra push.

Here are some other ways BPC-157 can act:

• Promoting granulation tissue formation: Granulation tissue is new connective tissue and tiny blood vessels that form on the surfaces of wounds during healing.
• Increasing collagen production: Collagen aids in skin rejuvenation which helps wounds close faster.
• Enhancing fibroblast outgrowth: Fibroblasts play an essential role in wound healing as they produce collagen and other fibers.

It doesn’t stop there though; BPC-157 also works wonders for gut health! Research shows that it can protect your intestinal tract against ulcers and inflammations.

Moreover, studies have suggested that this peptide might also have neuroprotective effects – meaning it could potentially safeguard your brain cells from damage or degeneration.

Here’s a diagram that breaks down the mechanism of action in an easy to understand way:

[IMG alt="Diagram explaining the mechanism of action and pathways of oral BPC-157"]https://sarms.io/wp-content/uploads/2023/07/oral-bpc-157-diagram.png[/IMG]
Introduction to Oral BPC-157: A Better Alternative to Injections?

Oral BPC-157​

Now let’s move on to the oral form of BPC 157. This peptide is commonly used in supplement form and can be taken orally – hence the name. Unlike some other peptides, oral BPC-157 isn’t degraded by stomach acid, making it effective when swallowed.

So why are people interested in it? Research suggests that BPC-157 may support wound healing and recovery from injuries. Studies on animals have shown promising results with this peptide enhancing tendon and ligament healing rates.

Here are some key points to remember about oral BPC-157:

• It’s derived from a protein found in the stomach.
• The substance can withstand stomach acid.
• Preliminary research indicates potential benefits for injury recovery.

However, don’t get too carried away yet! Remember that most studies on BPC-157 have been conducted on animals so far – not humans. That means we’re still learning about how it works and its full range of effects.

Oral BPC-157 Vs. Injectable BPC-157: Pros and Cons of Each Method

Oral BPC-157 Vs. Injectable​

When it comes to BPC-157, you’re likely wondering about the differences between oral and injectable forms. Well, let’s dive right in.

Oral BPC-157, as the name suggests, is taken by mouth. It’s a popular choice for many due to its convenience and ease of use. You simply swallow the capsule or tablet with water – no needles involved!

On the other hand, Injectable BPC-157 requires a bit more effort on your part as it involves using a syringe to administer the peptide directly into your body tissue.

But how do these two forms compare effectiveness-wise? Let’s break this down:

• Bioavailability: Injectable form generally has higher bioavailability than oral form which means more of it reaches your bloodstream.
• Speed of action: Injections usually work faster since they bypass digestive processes.
• Long-term effects: Some studies suggest that oral administration might offer longer-lasting benefits because of slow digestion and absorption rates.

Here’s a handy comparison table for quick reference:

	Oral BPC-157	Injectable BPC-157
Bioavailability	Lower	Higher
Speed of Action	Slower	Faster
Long-Term Effects	Possibly Longer Lasting	Not Fully Determined

Remember though, both forms have their own merits and drawbacks. The best choice ultimately depends on your personal preferences, health condition and goals. Always consult with healthcare professionals before starting any new treatment regimen.

In terms of safety profiles, both versions are generally well-tolerated with minimal side effects reported in research studies so far.

 

[NuSciencePeptides]

It would definitely have to be in an enteric coated capsule. Peptides can't tolerate stomach acid.

Yes, we plan on all our capsules to be enteric-coated.

 

[NuSciencePeptides]

You mentioned that you are also working on an oral BPC-157 product. Here is an interesting read:

Oral BPC-157: Top Benefits and Effects Compared to Injecting

Discover the benefits of oral BPC-157. Learn how it compares to injections, its profound effects, and why it's a total game changer.

sarms.io

Oral BPC-157: Unveiling Its Potential Benefits for Your Health​

Oral BPC-157, a peptide gaining popularity for its potential health benefits, is what we’re diving into today. You’ve likely heard whispers of it in the fitness community or seen it making rounds on wellness blogs. But what exactly is this compound, and how can it help you?

BPC-157, also known as body protection compound 157, isn’t just another fad – there’s science to back up its efficacy. From accelerating wound healing to easing digestive disorders and even combating depression, BPC-157 appears to be a promising all-around therapeutic agent.

In this article, we’ll unpack everything you need to know about oral BPC-157: how it works, its potential health benefits, and the research behind these claims. By the end of your read through our comprehensive guide on BPC-157, you’ll have a clear understanding if this peptide should make an appearance in your health regimen.

The Scientific Background of BPC-157

Background​

Dive into the world of BPC-157, a synthetic peptide with an intriguing scientific backstory. You might be wondering, “What’s a peptide?” It’s a short chain of amino acids, the building blocks that make up proteins in your body.

Now, let’s talk about BPC-157 specifically. Its full name is Body Protection Compound 157, indicating its potential protective effects. This particular peptide has been extensively studied in animal models for its regenerative and healing properties.

Interestingly enough, BPC-157 is derived from a protein found in stomach juice. Yes! Your very own gastric juice contains something similar to this powerful compound.

The magic lies in its ability to accelerate wound healing and tissue repair. Whether it’s muscle injuries or skin wounds – preliminary studies suggest BPC-157 can speed up the recovery process significantly.

Here are some key findings:

• In rat models, oral administration of BPC-157 showed remarkable improvement in tendon-to-bone healing.
• Another study observed accelerated recovery from muscle tears.
• Some research even suggests potential benefits for gastrointestinal health due to its origin from gastric proteins.

Study Focus	Animal Model	Outcome
Tendon-to-Bone Healing	Rats	Improvement
Muscle Tear Recovery	Rats	Acceleration
Gastrointestinal Health Benefits	Various Animals	Potential

Remember though; these results are primarily based on animal studies. Human trials are still limited but ongoing – so we’re yet to understand fully how effective and safe oral BPC-157 is for humans over the long term.


In summary: BPC-157 may seem like just another string of letters and numbers right now. But delve deeper into it and you’ll find fascinating science backed by promising research that could potentially enhance your body’s natural healing abilities!

BPC-157’s Mechanism of Action Explained in Simple Terms

Mechanism of Action​

BPC 157 is often praised for its potential healing properties. But how does it work exactly? Let’s delve into its mechanism of action.

Firstly, you’ll want to understand that BPC-157 is what we call a ‘stable gastric pentadecapeptide’. This means it’s composed of 15 amino acids and is derived from a part of our body – specifically, the gastric juice in your stomach. Now let’s get into the nitty-gritty.

One key way BPC-157 operates is by accelerating wound healing. It achieves this by boosting angiogenesis – the formation of new blood vessels from pre-existing ones. Your body naturally uses angiogenesis to heal injuries but with BPC-157, this process gets an extra push.

Here are some other ways BPC-157 can act:

• Promoting granulation tissue formation: Granulation tissue is new connective tissue and tiny blood vessels that form on the surfaces of wounds during healing.
• Increasing collagen production: Collagen aids in skin rejuvenation which helps wounds close faster.
• Enhancing fibroblast outgrowth: Fibroblasts play an essential role in wound healing as they produce collagen and other fibers.

It doesn’t stop there though; BPC-157 also works wonders for gut health! Research shows that it can protect your intestinal tract against ulcers and inflammations.

Moreover, studies have suggested that this peptide might also have neuroprotective effects – meaning it could potentially safeguard your brain cells from damage or degeneration.

Here’s a diagram that breaks down the mechanism of action in an easy to understand way:

[IMG alt="Diagram explaining the mechanism of action and pathways of oral BPC-157"]https://sarms.io/wp-content/uploads/2023/07/oral-bpc-157-diagram.png[/IMG]
Introduction to Oral BPC-157: A Better Alternative to Injections?

Oral BPC-157​

Now let’s move on to the oral form of BPC 157. This peptide is commonly used in supplement form and can be taken orally – hence the name. Unlike some other peptides, oral BPC-157 isn’t degraded by stomach acid, making it effective when swallowed.

So why are people interested in it? Research suggests that BPC-157 may support wound healing and recovery from injuries. Studies on animals have shown promising results with this peptide enhancing tendon and ligament healing rates.

Here are some key points to remember about oral BPC-157:

• It’s derived from a protein found in the stomach.
• The substance can withstand stomach acid.
• Preliminary research indicates potential benefits for injury recovery.

However, don’t get too carried away yet! Remember that most studies on BPC-157 have been conducted on animals so far – not humans. That means we’re still learning about how it works and its full range of effects.

Oral BPC-157 Vs. Injectable BPC-157: Pros and Cons of Each Method

Oral BPC-157 Vs. Injectable​

When it comes to BPC-157, you’re likely wondering about the differences between oral and injectable forms. Well, let’s dive right in.

Oral BPC-157, as the name suggests, is taken by mouth. It’s a popular choice for many due to its convenience and ease of use. You simply swallow the capsule or tablet with water – no needles involved!

On the other hand, Injectable BPC-157 requires a bit more effort on your part as it involves using a syringe to administer the peptide directly into your body tissue.

But how do these two forms compare effectiveness-wise? Let’s break this down:

• Bioavailability: Injectable form generally has higher bioavailability than oral form which means more of it reaches your bloodstream.
• Speed of action: Injections usually work faster since they bypass digestive processes.
• Long-term effects: Some studies suggest that oral administration might offer longer-lasting benefits because of slow digestion and absorption rates.

Here’s a handy comparison table for quick reference:

	Oral BPC-157	Injectable BPC-157
Bioavailability	Lower	Higher
Speed of Action	Slower	Faster
Long-Term Effects	Possibly Longer Lasting	Not Fully Determined

Remember though, both forms have their own merits and drawbacks. The best choice ultimately depends on your personal preferences, health condition and goals. Always consult with healthcare professionals before starting any new treatment regimen.


In terms of safety profiles, both versions are generally well-tolerated with minimal side effects reported in research studies so far.

That was an awesome read, thank you.

 

[BadassBlues]

That was an awesome read, thank you.

The effects on gut health were a surprise.

 

[BadassBlues]

I can see a possible potential for an oral BPC-157 product to be used in conjunction with Semaglutide or Tirzepatide due to the positive effects on the digestive system. Here is an interesting study:

Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications

Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide ...

www.ncbi.nlm.nih.gov

Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications​

Predrag Sikiric,1,* Sven Seiwerth,1 Rudolf Rucman,1 Danijela Kolenc,1 Lovorka Batelja Vuletic,1 Domagoj Drmic,1 Tihomir Grgic,1 Sanja Strbe,1 Goran Zukanovic,1 Dalibor Crvenkovic,1 Goran Madzarac,1 Iva Rukavina,1 Mario Sucic,1 Marko Baric,1 Neven Starcevic,1 Zoran Krstonijevic,1 Martina Lovric Bencic,1 Igor Filipcic,1 Dinko Stancic Rokotov,1 and Josipa Vlainic2
Author information Article notes Copyright and License information PMC Disclaimer

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Abstract​

Background​

Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic agent, safe in inflammatory bowel disease trials and now in multiple sclerosis trial, native and stable in human gastric juice.

Methods​

Review of our research on BPC 157 in terms of brain-gut axis.

Results​

BPC 157 may serve as a novel mediator of Robert’s cytoprotection, involved in maintaining of GI mucosa integrity, with no toxic effect. BPC 157 was successful in the therapy of GI tract, periodontitis, liver and pancreas lesions, and in the healing of various tissues and wounds. Stimulated Egr-1 gene, NAB2, FAK-paxillin and JAK-2 pathways are hitherto implicated. Initially corresponding beneficial central influence was seen when BPC 157 was given peripherally and a serotonin release in particular brain areas, mostly nigrostriatal, was changed. BPC 157 modulates serotonergic and dopaminergic systems, beneficially affects various behavioral disturbances that otherwise appeared due to specifically (over)stimulated/damaged neurotransmitters systems. Besides, BPC 157 has neuroprotective effects: protects somatosensory neurons; peripheral nerve regeneration appearent after transection; after traumatic brain injury counteracts the otherwise progressing course, in rat spinal cord compression with tail paralysis, axonal and neuronal necrosis, demyelination, cyst formation and rescues tail function in both short-terms and long-terms; after NSAIDs or insulin overdose or cuprizone encephalopathies were attenuated along with GI, liver and vascular injuries.

Conclusion​

BPC 157, a gastric peptide, may serve as remedy in various CNS-disorders.