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Success with 1:1 ratio of CBD:THC for sleep problems
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<blockquote data-quote="backdr10" data-source="post: 182378" data-attributes="member: 23430"><p>I’ll throw my opinion into the discussion and hope it is of some help as I instruct other physicians on the use of cannabis in the treatment of varying disease process including oncology . Being a doc , I also suffer from one of the worst cases of sleep apnea that any pulmonologist has seen . The diagnosis was prolonged and led to heart failure at 47 along with orthopnea. I half ass sleep with a bipap in a recliner and on some days function like the walking dead - so I can most definitely sympathize will your issue . I too instruct on integrative natural medicine use and have some success with pharmagaba among other pharmaceutical grade nutraceuticals - mostly sold to docs . Cbd is the neuroprotectant that binds to the cb2 receptor site Throughout the body including a bit in the brain protecting against the damage that Thc causes after binding to the cb1 receptor mainly in the brain. Cbd - when real and tested and quality - has a direct affect on the immune system and inflammatory cytokines throughout body . In some patients it has a relaxation effect but in others it has an excitatory effect and can cause allergic or cholinergic like stimulation and anxiety . So you are right with the 1:1 ratio as pot / indicas that are bred with Higher content of thc give a higher high but cause more brain cell destruction without the protection of cbd. I completely understand the desperation as I still seek the perfect answer but sleep is a very complex and A Multifactoral issue. Many patients that have used even the 1:1 ratio of cannabis long term have attempted to stop cannabis use for one reason or another and I have had to deal with their psychiatrists because of what happens next. Pot initially will help with sleep but secondary to its effects on the hippocampus / amygdala and frontal lobe over a period of time it will cause damage and sleep will become next to impossible to obtain. I have had patients unable to sleep more than 2-3 hours after stopping pot and even with the use of a variety of prescription meds they can not sleep and become psychotic . As a last resort, pot is reinstated and immediately they sleep and return to functional status. The endocannibinoid system goes into a state of overt deficiency after long term use and sleep becomes difficult to attain . Also, pot has an inverse relationship with testosterone production and has a feedback loop with many other hormones while interacting with many drugs. If you find a quality - real source of cbd you need to be careful with interactions with any drug that utilizes the p450 detox pathway through the liver as this will change the metabolism of either the drug or cbd and cause a problem with dosages . I hope you were tested for sleep apnea . Anyways , I do understand your problem completely And glad you are getting some relief with your protocol but I would take frequent breaks with cannabis use . Just a thought .</p></blockquote><p></p>
[QUOTE="backdr10, post: 182378, member: 23430"] I’ll throw my opinion into the discussion and hope it is of some help as I instruct other physicians on the use of cannabis in the treatment of varying disease process including oncology . Being a doc , I also suffer from one of the worst cases of sleep apnea that any pulmonologist has seen . The diagnosis was prolonged and led to heart failure at 47 along with orthopnea. I half ass sleep with a bipap in a recliner and on some days function like the walking dead - so I can most definitely sympathize will your issue . I too instruct on integrative natural medicine use and have some success with pharmagaba among other pharmaceutical grade nutraceuticals - mostly sold to docs . Cbd is the neuroprotectant that binds to the cb2 receptor site Throughout the body including a bit in the brain protecting against the damage that Thc causes after binding to the cb1 receptor mainly in the brain. Cbd - when real and tested and quality - has a direct affect on the immune system and inflammatory cytokines throughout body . In some patients it has a relaxation effect but in others it has an excitatory effect and can cause allergic or cholinergic like stimulation and anxiety . So you are right with the 1:1 ratio as pot / indicas that are bred with Higher content of thc give a higher high but cause more brain cell destruction without the protection of cbd. I completely understand the desperation as I still seek the perfect answer but sleep is a very complex and A Multifactoral issue. Many patients that have used even the 1:1 ratio of cannabis long term have attempted to stop cannabis use for one reason or another and I have had to deal with their psychiatrists because of what happens next. Pot initially will help with sleep but secondary to its effects on the hippocampus / amygdala and frontal lobe over a period of time it will cause damage and sleep will become next to impossible to obtain. I have had patients unable to sleep more than 2-3 hours after stopping pot and even with the use of a variety of prescription meds they can not sleep and become psychotic . As a last resort, pot is reinstated and immediately they sleep and return to functional status. The endocannibinoid system goes into a state of overt deficiency after long term use and sleep becomes difficult to attain . Also, pot has an inverse relationship with testosterone production and has a feedback loop with many other hormones while interacting with many drugs. If you find a quality - real source of cbd you need to be careful with interactions with any drug that utilizes the p450 detox pathway through the liver as this will change the metabolism of either the drug or cbd and cause a problem with dosages . I hope you were tested for sleep apnea . Anyways , I do understand your problem completely And glad you are getting some relief with your protocol but I would take frequent breaks with cannabis use . Just a thought . [/QUOTE]
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Success with 1:1 ratio of CBD:THC for sleep problems
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