ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raising ferritin FAST (a how-to, not a question)
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 209696" data-attributes="member: 38109"><p>Some additional details on using an ester blend to reduce the dose of testosterone: If the desire is to preserve peak serum testosterone while restricting the daily variation in levels to something physiological then the variation about the mean should be limited to +/- 25% or so. This is about the highest natural variation I've seen in the literature. You can also look at this as having daily trough testosterone be 60% of the peak value. If we model the variation as linear then we can readily see that going from relatively constant testosterone levels—as in daily cypionate injections—to this maximum physiological variation reduces the average serum level by 20%, which is also the amount of the dose reduction.</p><p></p><p>I've been using total testosterone and free testosterone somewhat interchangeably in all this, but strictly speaking the calculations should be based only on free testosterone.</p><p></p><p>If you abandon the requirement that serum testosterone variation remain physiological then in theory by using only propionate you can reduce the overall testosterone dose by a third, assuming your absorption rate is typical. Larger reductions in total testosterone dose are conceivable if testosterone nasal gel, e.g. Natesto, is incorporated in the protocol.</p><p></p><p>Ideally each person should measure the serum testosterone variation he sees with propionate so that an ester blend can be tailored appropriately. This is effectively measuring the half-life of propionate. As it happens, that figure of 50% I measured corresponds pretty well with the nominal stated half-life of 0.8 days. However, it's quite possible for any individual to absorb the ester faster or slower.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 209696, member: 38109"] Some additional details on using an ester blend to reduce the dose of testosterone: If the desire is to preserve peak serum testosterone while restricting the daily variation in levels to something physiological then the variation about the mean should be limited to +/- 25% or so. This is about the highest natural variation I've seen in the literature. You can also look at this as having daily trough testosterone be 60% of the peak value. If we model the variation as linear then we can readily see that going from relatively constant testosterone levels—as in daily cypionate injections—to this maximum physiological variation reduces the average serum level by 20%, which is also the amount of the dose reduction. I've been using total testosterone and free testosterone somewhat interchangeably in all this, but strictly speaking the calculations should be based only on free testosterone. If you abandon the requirement that serum testosterone variation remain physiological then in theory by using only propionate you can reduce the overall testosterone dose by a third, assuming your absorption rate is typical. Larger reductions in total testosterone dose are conceivable if testosterone nasal gel, e.g. Natesto, is incorporated in the protocol. Ideally each person should measure the serum testosterone variation he sees with propionate so that an ester blend can be tailored appropriately. This is effectively measuring the half-life of propionate. As it happens, that figure of 50% I measured corresponds pretty well with the nominal stated half-life of 0.8 days. However, it's quite possible for any individual to absorb the ester faster or slower. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raising ferritin FAST (a how-to, not a question)
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top