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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raising ferritin FAST (a how-to, not a question)
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<blockquote data-quote="Cataceous" data-source="post: 209678" data-attributes="member: 38109"><p>My average Tru-T free testosterone is predicted pretty accurately as 0.627 * (weekly testosterone intake). For example, when I was taking 18 mg T enanthate EOD my Tru-T free was about 28 ng/dL—my SHBG is usually around 30 nMol/L. Total testosterone then was around 800 ng/dL.</p><p></p><p>The measurements get a lot noisier once propionate is in the picture. I accumulated the following data when using only propionate daily:</p><p></p><p><strong>[ATTACH=full]16886[/ATTACH]</strong></p><p>I dismiss the 6 mg reading as an outlier, leading me to use a figure of 50% as the daily variation about the mean in my serum testosterone. With this number I can estimate the variation about the mean with any blend as 50% * percent_T_from_TP_in_blend. Thus if half of my testosterone is coming from TP and half from a longer ester then variability in serum testosterone about the mean is predicted to be 25%. This is what I targeted with my blend. Daily doses ranged from 2.8 mg TP/3.7 mg TE (5 mg T) down to 2.1 mg TP/2.8 mg TE (3.8 mg T). Subjectively the best was 2.4 mg TP/3.2 mg TE (4.3 mg T).</p><p></p><p>Regarding your situation: It's useful to get a sense of your dose-response characteristic. In theory the dose proportionally drives free T. What is your SHBG like? Lower levels lead to less total testosterone. Is that TT of 550 ng/dL at trough? I personally see little serum variation with EOD use of longer esters, but anecdotally—and uncommonly—it seems like some guys see a fair bit of variation. Are you a large guy? This is another factor that influences the response to dose.</p><p></p><p>As discussed in the other thread, it's hypothesized that daily peak testosterone has beneficial effects that are independent of average and trough levels. If so, and if hematocrit happens to be relatively decoupled from daily peak testosterone then it may be possible to lower hematocrit by lowering average and trough testosterone while preserving peak values and their attendant benefits.</p><p></p><p>I'll add one anecdote: I'm conducting a test at the moment with a considerably lower dose of only propionate, 4.5 mg daily. While peak testosterone is predicted to be over 700 ng/dL, trough testosterone is likely in the 200s. The interesting thing is that since the transition period there have been no obvious subjective problems with having such low troughs. There could still be less obvious problems that will be uncovered with lab work.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 209678, member: 38109"] My average Tru-T free testosterone is predicted pretty accurately as 0.627 * (weekly testosterone intake). For example, when I was taking 18 mg T enanthate EOD my Tru-T free was about 28 ng/dL—my SHBG is usually around 30 nMol/L. Total testosterone then was around 800 ng/dL. The measurements get a lot noisier once propionate is in the picture. I accumulated the following data when using only propionate daily: [B][ATTACH type="full"]16886[/ATTACH][/B] I dismiss the 6 mg reading as an outlier, leading me to use a figure of 50% as the daily variation about the mean in my serum testosterone. With this number I can estimate the variation about the mean with any blend as 50% * percent_T_from_TP_in_blend. Thus if half of my testosterone is coming from TP and half from a longer ester then variability in serum testosterone about the mean is predicted to be 25%. This is what I targeted with my blend. Daily doses ranged from 2.8 mg TP/3.7 mg TE (5 mg T) down to 2.1 mg TP/2.8 mg TE (3.8 mg T). Subjectively the best was 2.4 mg TP/3.2 mg TE (4.3 mg T). Regarding your situation: It's useful to get a sense of your dose-response characteristic. In theory the dose proportionally drives free T. What is your SHBG like? Lower levels lead to less total testosterone. Is that TT of 550 ng/dL at trough? I personally see little serum variation with EOD use of longer esters, but anecdotally—and uncommonly—it seems like some guys see a fair bit of variation. Are you a large guy? This is another factor that influences the response to dose. As discussed in the other thread, it's hypothesized that daily peak testosterone has beneficial effects that are independent of average and trough levels. If so, and if hematocrit happens to be relatively decoupled from daily peak testosterone then it may be possible to lower hematocrit by lowering average and trough testosterone while preserving peak values and their attendant benefits. I'll add one anecdote: I'm conducting a test at the moment with a considerably lower dose of only propionate, 4.5 mg daily. While peak testosterone is predicted to be over 700 ng/dL, trough testosterone is likely in the 200s. The interesting thing is that since the transition period there have been no obvious subjective problems with having such low troughs. There could still be less obvious problems that will be uncovered with lab work. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raising ferritin FAST (a how-to, not a question)
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