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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Oral growth hormone enhancer MK-677 (ibutamoren)
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<blockquote data-quote="BigTex" data-source="post: 237464" data-attributes="member: 43589"><p>I wanted to add this to the "GH bleed" comments made in reference to MK-677 use just to further explain the actions of MK-677. Like ALL GHRP's, MK-677 binds to the ghrelin receptor and was found to not only enhance the pulsatile release of GH but also act as an antagonist to somatostatin allowing for GH levels to remain elevated (1,2). Remember, when serum GH/IGF-1 levels get too high, homeostasis is reached by releasing somatostatin which shuts blunts the natural GH pulses. You can not reach the same level of pulses with GHRH (sermorelin, GRF-1-29, CJC, CJC w/DAC etc) unless you add either a GHRP or MK-677 to it.</p><p></p><p>1. Karydis I, Tolis A, Tolis G. New GH secretagogues and potential usefulness in thalassemia. J Pediatr Endocrinol Metab. 1998;11 Suppl 3:857-862.</p><p></p><p>2. Adunsky A, Chandler J, Heyden N, et al. MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Arch Gerontol Geriatr. 2011;53(2):183-189.</p></blockquote><p></p>
[QUOTE="BigTex, post: 237464, member: 43589"] I wanted to add this to the "GH bleed" comments made in reference to MK-677 use just to further explain the actions of MK-677. Like ALL GHRP's, MK-677 binds to the ghrelin receptor and was found to not only enhance the pulsatile release of GH but also act as an antagonist to somatostatin allowing for GH levels to remain elevated (1,2). Remember, when serum GH/IGF-1 levels get too high, homeostasis is reached by releasing somatostatin which shuts blunts the natural GH pulses. You can not reach the same level of pulses with GHRH (sermorelin, GRF-1-29, CJC, CJC w/DAC etc) unless you add either a GHRP or MK-677 to it. 1. Karydis I, Tolis A, Tolis G. New GH secretagogues and potential usefulness in thalassemia. J Pediatr Endocrinol Metab. 1998;11 Suppl 3:857-862. 2. Adunsky A, Chandler J, Heyden N, et al. MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Arch Gerontol Geriatr. 2011;53(2):183-189. [/QUOTE]
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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Oral growth hormone enhancer MK-677 (ibutamoren)
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