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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Optimum IGF-1 Levels
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<blockquote data-quote="Cataceous" data-source="post: 186050" data-attributes="member: 38109"><p>Regarding why enclomiphene reduces IGF-1, I don't know more than what the study's authors say:</p><p></p><p style="margin-left: 20px"><em>IGF-1 levels were decreased in the men in the enclomiphene citrate groups, but not in the transdermal testosterone group, but the levels remained within the normal physiological ranges. We are uncertain as to the significance of this observation. Testosterone treatment of men with testosterone deficiency usually increases serum estradiol levels, and may increase hGH and IGF-1 levels. Estrogen is known to potentiate secretion of hGH and IGF-1 levels. Enclomiphene citrate increases serum estradiol levels. <strong>We suspect that the anti-estrogen effects of enclomiphene citrate are working at either the hypothalamic-pituitary level or possibly on the liver to reduce IGF-1 levels.</strong> Unfortunately, technical issues prevented the measurement of hGH levels in the serum samples from these men. It would also be relevant to know if enclomiphene citrate treatment affects the IGF-binding proteins.</em></p> <p style="margin-left: 20px"></p><p>As for an "optimized level" for IGF-1, I think you need to define what you're wanting to optimize. Such levels may well differ between goals like maximizing longevity or maximizing athletic performance and recovery. Though the debate continues, my impression is that for longevity it is safest to be low-midrange for your age.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 186050, member: 38109"] Regarding why enclomiphene reduces IGF-1, I don't know more than what the study's authors say: [INDENT][I]IGF-1 levels were decreased in the men in the enclomiphene citrate groups, but not in the transdermal testosterone group, but the levels remained within the normal physiological ranges. We are uncertain as to the significance of this observation. Testosterone treatment of men with testosterone deficiency usually increases serum estradiol levels, and may increase hGH and IGF-1 levels. Estrogen is known to potentiate secretion of hGH and IGF-1 levels. Enclomiphene citrate increases serum estradiol levels. [B]We suspect that the anti-estrogen effects of enclomiphene citrate are working at either the hypothalamic-pituitary level or possibly on the liver to reduce IGF-1 levels.[/B] Unfortunately, technical issues prevented the measurement of hGH levels in the serum samples from these men. It would also be relevant to know if enclomiphene citrate treatment affects the IGF-binding proteins.[/I][/INDENT] [INDENT][/INDENT] As for an "optimized level" for IGF-1, I think you need to define what you're wanting to optimize. Such levels may well differ between goals like maximizing longevity or maximizing athletic performance and recovery. Though the debate continues, my impression is that for longevity it is safest to be low-midrange for your age. [/QUOTE]
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