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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
LOH: reductio ad absurdum of the cardiovascular risk–benefit of TRT
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<blockquote data-quote="madman" data-source="post: 183480" data-attributes="member: 13851"><p>[ATTACH=full]10263[/ATTACH]</p><p>[ATTACH=full]10264[/ATTACH]</p><p>[ATTACH=full]10265[/ATTACH]</p><p><strong><span style="color: rgb(0, 0, 0)">Table 1.</span><span style="color: rgb(184, 49, 47)"> Summary of the effects of testosterone on vessel and endothelial function: small, medium, large vessels.</span> <span style="color: rgb(44, 130, 201)">Coronary arteries vasomotion. </span>Testosterone exerts a vasodilating action through a rapid, non-genomic, and endothelial-independent action on K and Ca channels. Moreover, it has also an endothelial-dependent vasodilating effect mediated by NO. <span style="color: rgb(44, 130, 201)">Peripheral arterial stiffness. </span>Testosterone reduces arterial stiffness through, an androgen receptor-dependent modulation of apoptosis and senescence of vascular smooth muscle cells. Testosterone vasodilating action and anti-inflammatory effects may also have a role. <span style="color: rgb(44, 130, 201)">Large vessel atherosclerosis.</span> Testosterone exerts several anti-atherogenic actions, including an anti-inflammatory effect which may hinder the initial development of atheroma. The effect on VSMSs is complex and may be reliant on the stage of plaque development. VSMCs migration and proliferation could be considered protective against plaque destabilization, while VSMCs apoptosis could be responsible for plaque vulnerability </strong></p></blockquote><p></p>
[QUOTE="madman, post: 183480, member: 13851"] [ATTACH type="full"]10263[/ATTACH] [ATTACH type="full"]10264[/ATTACH] [ATTACH type="full"]10265[/ATTACH] [B][COLOR=rgb(0, 0, 0)]Table 1.[/COLOR][COLOR=rgb(184, 49, 47)] Summary of the effects of testosterone on vessel and endothelial function: small, medium, large vessels.[/COLOR] [COLOR=rgb(44, 130, 201)]Coronary arteries vasomotion. [/COLOR]Testosterone exerts a vasodilating action through a rapid, non-genomic, and endothelial-independent action on K and Ca channels. Moreover, it has also an endothelial-dependent vasodilating effect mediated by NO. [COLOR=rgb(44, 130, 201)]Peripheral arterial stiffness. [/COLOR]Testosterone reduces arterial stiffness through, an androgen receptor-dependent modulation of apoptosis and senescence of vascular smooth muscle cells. Testosterone vasodilating action and anti-inflammatory effects may also have a role. [COLOR=rgb(44, 130, 201)]Large vessel atherosclerosis.[/COLOR] Testosterone exerts several anti-atherogenic actions, including an anti-inflammatory effect which may hinder the initial development of atheroma. The effect on VSMSs is complex and may be reliant on the stage of plaque development. VSMCs migration and proliferation could be considered protective against plaque destabilization, while VSMCs apoptosis could be responsible for plaque vulnerability [/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
LOH: reductio ad absurdum of the cardiovascular risk–benefit of TRT
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