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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="madman" data-source="post: 243953" data-attributes="member: 13851"><p>Might as well throw this in here too for the time being so everyone can gloat!</p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/measurement-of-ft-in-serum-using-ed-coupled-with-id-uhplc-ms-ms-in-comparison-to-cftv.26364/[/URL]</p><p></p><p></p><p>[ATTACH=full]28618[/ATTACH]</p><p>[ATTACH=full]28619[/ATTACH]</p><p></p><p>A majority of the calculated values overestimated FT concentration compared to measured values (ED UHPLC-MS/MS).</p><p></p><p>The mean bias was 34.5% and a higher bias (upwards of 60%) was seen in the samples with low FT concentrations.</p><p></p><p>Two of the cFT values had a negative bias.</p><p></p><p>Yet even after the data shown in Fiers 2018 study let and the most recent 2021 comparison posted above (CDC standardized high throughput ED device vs cFTV) the cFTZ camp is still dead set on proving that the liner law-of-mass action model/empiric equations are wrong.</p><p></p><p>Post #132/133 of this thread.</p><p></p><p>2023 and still pursuing it! (<a href="https://xyonetx.com/science/#endocrinologyid" target="_blank">Science – XYone Therapeutics</a>)</p><p></p><p>Just to be clear Bhasin's ED device (Harvard Apparatus DispoEquillibrium Dialyzers) is not the same as the CDCs reference ED device (Harvard Apparatus Micro-Equillibrium Dialyzer System, 1 mL cells) or the newer standardized CDC high throughput ED device (MD1000 dialyzer with customized in-house 3-D printed base plate) let alone any of the ED devices used across the different laboratories.</p><p></p><p>A critical point to be made here is everyone needs to keep in mind that some ED devices show a large bias compared to the CDCs reference device </p><p></p><p>This is why we need CDC harmonized/standardization of free testosterone.</p><p></p><p>We already know where Bhasin stands on the linear law-of-mass action/empiric equations.</p><p></p><p>Still going to be a few years before this s**t show comes to an end.</p><p></p><p>Better yet if this is still eating anyone up then grow some balls and contact Dr. Bhasin or Dr. Jasuja!</p><p></p><p>You may be able to pry something out of them LOL!</p></blockquote><p></p>
[QUOTE="madman, post: 243953, member: 13851"] Might as well throw this in here too for the time being so everyone can gloat! [URL unfurl="true"]https://www.excelmale.com/forum/threads/measurement-of-ft-in-serum-using-ed-coupled-with-id-uhplc-ms-ms-in-comparison-to-cftv.26364/[/URL] [ATTACH type="full"]28618[/ATTACH] [ATTACH type="full"]28619[/ATTACH] A majority of the calculated values overestimated FT concentration compared to measured values (ED UHPLC-MS/MS). The mean bias was 34.5% and a higher bias (upwards of 60%) was seen in the samples with low FT concentrations. Two of the cFT values had a negative bias. Yet even after the data shown in Fiers 2018 study let and the most recent 2021 comparison posted above (CDC standardized high throughput ED device vs cFTV) the cFTZ camp is still dead set on proving that the liner law-of-mass action model/empiric equations are wrong. Post #132/133 of this thread. 2023 and still pursuing it! ([URL="https://xyonetx.com/science/#endocrinologyid"]Science – XYone Therapeutics[/URL]) Just to be clear Bhasin's ED device (Harvard Apparatus DispoEquillibrium Dialyzers) is not the same as the CDCs reference ED device (Harvard Apparatus Micro-Equillibrium Dialyzer System, 1 mL cells) or the newer standardized CDC high throughput ED device (MD1000 dialyzer with customized in-house 3-D printed base plate) let alone any of the ED devices used across the different laboratories. A critical point to be made here is everyone needs to keep in mind that some ED devices show a large bias compared to the CDCs reference device This is why we need CDC harmonized/standardization of free testosterone. We already know where Bhasin stands on the linear law-of-mass action/empiric equations. Still going to be a few years before this s**t show comes to an end. Better yet if this is still eating anyone up then grow some balls and contact Dr. Bhasin or Dr. Jasuja! You may be able to pry something out of them LOL! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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